The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Physiological role of ROCKs in the cardiovascular system
Open accessAbstract
Rho-associated kinases (ROCKs), the immediate downstream targets of RhoA, are ubiquitously expressed serine-threonine protein kinases that are involved in diverse cellular functions, including smooth muscle contraction, actin cytoskeleton organization, cell adhesion and motility, and gene expression. Recent studies have shown that ROCKs may play a pivotal role in cardiovascular diseases such as vasospastic angina, ischemic stroke, and heart failure. Indeed, inhibition of ROCKs by statins or other selective inhibitors leads to the upregulation and activation of endothelial nitric oxide synthase (eNOS) and reduction of vascular inflammation and atherosclerosis. Thus inhibition of ROCKs may contribute to some of the cholesterol-independent beneficial effects of statin therapy. Currently, two ROCK isoforms have been identified, ROCK1 and ROCK2. Because ROCK inhibitors are nonselective with respect to ROCK1 and ROCK2 and also, in some cases, may be nonspecific with respect to other ROCK-related kinases such as myristolated alanine-rich C kinase substrate (MARCKS), protein kinase A, and protein kinase C, the precise role of ROCKs in cardiovascular disease remains unknown. However, with the recent development of ROCK1- and ROCK2-knockout mice, further dissection of ROCK signaling pathways is now possible. Herein we review what is known about the physiological role of ROCKs in the cardiovascular system and speculate about how inhibition of ROCKs could provide cardiovascular benefits.
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Cites
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Pleiotropic Effects of Statins on the Cardiovascular System
Oesterle, A., Laufs, U., & Liao, J. K. (2017) · Circulation Research · doi:10.1161/circresaha.116.308537 · Cited by 1,247
Self-citationSubstrate Stiffness Affects the Functional Maturation of Neonatal Rat Ventricular Myocytes
Jacot, J. G., McCulloch, A. D., & Omens, J. H. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.124545 · Cited by 448
Rho kinase in the regulation of cell death and survival
Shi, J., & Wei, L. (2007) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-007-0009-7 · Cited by 254
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Metadata
- Authors
- Noma, K., Oyama, N., & Liao, J. K.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2006-03
- Volume
- 290
- Issue
- 3
- Pages
- C661-C668
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2131045378
- Cited by
- 371
- References
- 127
- FWCI
- 14.98
- Type
- journal article
- Language
- en
- Open access
- green
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