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Cited by 254Protein Kinase Regulation and GTPase SignalingCell death mechanisms and regulationHippo pathway signaling and YAP/TAZ

Rho kinase in the regulation of cell death and survival

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Shi, Jianjian, Wei, Lei·2007·Archivum Immunologiae et Therapiae Experimentalis
DOI 10.1007/s00005-007-0009-7PMC PMC2612781
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Abstract

Rho kinase (ROCK) belongs to a family of serine/threonine kinases that are activated via interaction with Rho GTPases. ROCK is involved in a wide range of fundamental cellular functions, such as contraction, adhesion, migration, and proliferation. Recent studies have shown that ROCK plays an important role in the regulation of apoptosis in various cell types and animal disease models. Two ROCK isoforms, ROCK1 and ROCK2, are assumed to be function redundant, this based largely on kinase construct overexpression and chemical inhibitors (Y27632 and fasudil) which inhibit both ROCK1 and ROCK2. Gene targeting and RNA interference approaches allow further dissection of distinct cellular, physiological, and patho-physiological functions of the two ROCK isoforms. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling in the regulation of apoptosis and highlights new findings from recently generated ROCK-deficient mice.

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  • Cytoskeletal rearrangement induced by ROCK activation can be involved in apoptosis.

    “The cytoskeletal rearrangement induced by ROCK activation can also be involved in apoptosis.”

    From RhoA Signaling in Neurodegenerative Diseases (2022) · cites this paper as [130]

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Sorted by citations

Authors
Shi, J., & Wei, L.
Affiliations
Indiana University Indianapolis (US)
Corresponding author
Wei, Lei
ORCID
Venue
Archivum Immunologiae et Therapiae Experimentalis
Publisher
Walter de Gruyter GmbH
Published
2007-03-09
Volume
55
Issue
2
Pages
61-75
ISSN
  • 0004-069X (ISSN-L)
  • 1661-4917
DOI
10.1007/s00005-007-0009-7
PMC
PMC2612781
OpenAlex
W1980081948
Cited by
254
References
4
Citations by year
2026: 9 · 2025: 15 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 9 · 2020: 14 · 2019: 12 · 2018: 8 · 2017: 5 · 2016: 16 · 2015: 19 · 2014: 16 · 2013: 23 · 2012: 20
FWCI
5.67
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Archivum Immunologiae et Therapiae Experimentalis (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • IUScholarWorks (Indiana University) (submittedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL-72897, P01HL085098, R01HL072897)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059142)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords
Rho kinase, ROCK1, ROCK2, apoptosis, cell survival, Rho GTPases, ROCK signaling, fasudil, Y-27632, serine/threonine kinase
MeSH terms
Animals, Cell Survival, Models, Biological, Substrate Specificity, Signal Transduction, Gene Expression Regulation, Enzymologic, Cell Death, Apoptosis, Protein Serine-Threonine Kinases, Mice, Knockout, Protein Isoforms, Intracellular Signaling Peptides and Proteins, Mice, rho-Associated Kinases

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