The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of oxygen tension on cellular energetics
Abstract
Simultaneous measurements of the mitochondrial [NAD+]/[NADH], the cytoplasmic [ATP]/[ADP] x [Pi], and the respiratory rate were carried out in suspensions of cultured kidney cells in a range of defined oxygen tensions. The results show that as the extracellular oxygen concentration falls there is a decrease in the respiratory rate, which is accompanied by a decrease in the [ATP]/[ADP] and a progressive reduction of cytochrome c. Even at low O2 tensions the mitochondrial respiratory chain between the NAD couple and cytochrome c remains at near equilibrium with the ATP synthesizing reactions. It is concluded that limited oxygen supply affects cellular metabolism at much higher concentrations than the P50 value for the oxygen dependence of respiration, but the respiratory rate remains relatively unchanged due to compensatory changes in the [ATP]/[ADP] X [Pi] and progressive reduction of cytochrome c. These metabolic changes may form a basis for the phenomenon of tissue oxygen sensing at near physiological oxygen tensions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Williamson, D., Lund, P., & Krebs, H. (1967) · Biochemical Journal · doi:10.1042/bj1030514 · Cited by 1,871
Cited by
Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.
Richardson, R. S., Noyszewski, E. A., Kendrick, K. F., Leigh, J. S., & Wagner, P. D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118237 · Cited by 647
The oxygen dependence of cellular energy metabolism
Wilson, D. F., Erecińska, M., Drown, C., & Silver, I. A. (1979) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(79)90375-8 · Cited by 366
Self-citationSignificant Molecular and Systemic Adaptations after Repeated Sprint Training in Hypoxia
Faiss, R., Léger, B., Vesin, J.-M., Fournier, P.-E., Eggel, Y., Dériaz, O., & Millet, G. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056522 · Cited by 294
Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival
Frezza, C., Zheng, L., Tennant, D. A., Papkovsky, D. B., Hedley, B. A., Kalna, G., Watson, D. G., & Gottlieb, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024411 · Cited by 177
Jones, A. M., Wilkerson, D. P., Koppo, K., Wilmshurst, S., & Campbell, I. T. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.045799 · Cited by 94
Metadata
- Authors
- Wilson, D. F., Erecinska, M., Drown, C., & Silver, I. A.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1977-11-01
- Volume
- 233
- Issue
- 5
- Pages
- C135-C140
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2149274776
- Cited by
- 216
- References
- 1
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effect of oxygen tension on cellular energetics. https://app.cochat.ai/papers/10.1152/ajpcell.1977.233.5.c135
- The paper
- Wilson, D. F., Erecinska, M., Drown, C., & Silver, I. A. (1977). Effect of oxygen tension on cellular energetics. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1977.233.5.c135
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
