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The generation of electric currents in cardiac fibers by Na/Ca exchange
Abstract
The presence of a detectable Ca current during the excitation of a cardiac fiber implies that the Ca lost during the resting interval of the duty cycle must also be detectable. Ca outward movement appears to be effected by Na/Ca exchange when more Na enters than Ca leaves per cycle, thus making the mechanism electrogenic. Since Na/Ca exchange can move Ca either inward or outward depending on the direction of the electrochemical gradient for Na, a potential exists where there is no electric current generated by the Na/Ca exchange mechanism, i.e., a reversal potential ER. Cardiac fibers appear to have a reversal potential that is about midway between their resting membrane potential and their plateau. Carrier currents both inward and outward are therefore generated during cardiac action potentials. The implications of the conditions stated above are explored.
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Citations
Cited by
Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias
KLÉBER, A. G., & RUDY, Y. (2004) · Physiological Reviews · doi:10.1152/physrev.00025.2003 · Cited by 1,083
Calcium Absorption Across Epithelia
Hoenderop, J. G. J., Nilius, B., & Bindels, R. J. M. (2005) · Physiological Reviews · doi:10.1152/physrev.00003.2004 · Cited by 936
Beuckelmann, D. J., Näbauer, M., & Erdmann, E. (1992) · Circulation · doi:10.1161/01.cir.85.3.1046 · Cited by 600
The stoichiometry of the cardiac sodium-calcium exchange system.
Reeves, J. P., & Hale, C. C. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42854-7 · Cited by 428
Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems
Hartzell, H. C. (1988) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(88)90014-4 · Cited by 398
Metadata
- Authors
- Mullins, L. J.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1979-03-01
- Volume
- 236
- Issue
- 3
- Pages
- C103-C110
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2219369075
- Cited by
- 398
- References
- 0
- FWCI
- 16.29
- Type
- journal article
- Language
- en
- Open access
- closed
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