The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.
Open accessAbstract
BACKGROUND: Experiments were performed in human ventricular myocytes to investigate properties of excitation-contraction coupling in patients with terminal heart failure. Myocytes were isolated from left ventricular myocardium of patients with cardiac failure caused by dilated or ischemic cardiomyopathy undergoing transplantation. These results were compared with those obtained from cells of healthy donor hearts that for technical reasons were not suitable for transplantation. METHODS AND RESULTS: [Ca2+]i transients and Ca2+ currents were recorded from isolated cells under voltage clamp perfused internally with the Ca2+ indicator fura 2. In cells that were stimulated externally, the cell-permeant form of the indicator, fura 2-AM, was used. When action potentials were to be recorded, cells were stimulated in current clamp mode. Unstimulated Ca2+ current densities were not significantly different in myopathic and control cells. In diseased myocytes, resting [Ca2+]i levels were 165 +/- 61 nmol/l, compared with 95 +/- 47 nmol/l in normal cells. With 5 mmol/l Na+ in the pipette, peak [Ca2+]i transients were 367 +/- 109 and 746 +/- 249 nmol/l, respectively. The decline of [Ca2+]i during diastole was significantly slower in myopathic cells than in control cells. This was a result of a prolongation of the action potential and of a reduced Ca2+ sequestration by the sarcoplasmic reticulum. CONCLUSIONS: These results may partly explain the alterations of contractility in vivo in patients with heart failure.
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Cites
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Self-citationThe generation of electric currents in cardiac fibers by Na/Ca exchange
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Cited by
Paulus, W. J., Tschöpe, C., Sanderson, J. E., Rusconi, C., Flachskampf, F. A., Rademakers, F. E., Marino, P., Smiseth, O. A., De Keulenaer, G., Leite-Moreira, A. F., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm037 · Cited by 2,679
Phospholamban: a crucial regulator of cardiac contractility
MacLennan, D. H., & Kranias, E. G. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1151 · Cited by 1,088
Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure
Gómez, A. M., Valdivia, H. H., Cheng, H., Lederer, M. R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., & Lederer, W. J. (1997) · Science · doi:10.1126/science.276.5313.800 · Cited by 758
Haghighi, K., Kolokathis, F., Pater, L., Lynch, R. A., Asahi, M., Gramolini, A. O., Fan, G.-C., Tsiapras, D., Hahn, H. S., Adamopoulos, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17892 · Cited by 478
Schwinger, R. H. G., Böhm, M., Schmidt, U., Karczewski, P., Bavendiek, U., Flesch, M., Krause, E.-G., & Erdmann, E. (1995) · Circulation · doi:10.1161/01.cir.92.11.3220 · Cited by 395
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Metadata
- Authors
- Beuckelmann, D. J., Näbauer, M., & Erdmann, E.
- Venue
- Circulation
- Published
- 1992-03
- Volume
- 85
- Issue
- 3
- Pages
- 1046-1055
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1979869140
- Cited by
- 600
- References
- 24
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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