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Cited by 143Biochemical and Molecular ResearchAdenosine and Purinergic SignalingMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

AMP deamination and IMP reamination in working skeletal muscle

Meyer, R. A., Terjung, R. L.·1980·American Journal of Physiology-Cell Physiology
DOI 10.1152/ajpcell.1980.239.1.c32
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Abstract

The extent of purine nucleotide cycle (PNC) turnover [i.e., the cyclic deamination of adenosine 5'-monophosphate (AMP) and reamination of inosine 5'-monophosphate (IMP)] was estimated in fast-twitch muscle of pentobarbital sodium anesthetized rats during in situ stimulation, by the accumulation of excess IMP after blocking IMP reamination with the adenylosuccinate synthetase inhibitor, hadacidin. Sodium hadacidin (100 mg/kg, iv) did not alter IMP production and was effective in blocking IMP reamination by 80%. Hadacidin had no effect on IMP levels in muscle at rest or during mild stimulation (1 Hz for 30 min). During 30 min of more intense stimulation (5 Hz), hadacidin treatment resulted in a threefold increase in IMP in the fast-twitch white gastrocnemius section, but had no effect in the fast-twitch red section. The IMP in the fast-twitch white section did not accumulate over the 30-min period, but was produced initially (within 5 min) and kept for being reaminated by hadacidin. Thus, the IMP formation and IMP reamination evident in the saline-injected animals did not occur concurrently. This suggests that the IMP reamination arm of the PNC is not an important pathway in "working" muscle.

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Crossref · 10.1152/ajpcell.1980.239.1.c32

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Metadata

Authors
Meyer, R. A., & Terjung, R. L.
Affiliations
SUNY Upstate Medical University (US)
Venue
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Published
1980-07-01
Volume
239
Issue
1
Pages
C32-C38
ISSN
  • 0363-6143 (ISSN-L)
  • 1522-1563
DOI
10.1152/ajpcell.1980.239.1.c32
OpenAlex
W119330955
Cited by
143
References
12
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2
FWCI
1.42
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Cell Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
purine nucleotide cycle, AMP deamination, adenylosuccinate synthetase, hadacidin, skeletal muscle, fast-twitch muscle, inosine 5'-monophosphate, muscle stimulation, gastrocnemius, red and white muscle fibers
MeSH terms
Adenosine Diphosphate, Adenosine Monophosphate, Adenosine Triphosphate, Ammonia, Animals, Physical Exertion, Formaldehyde, Glycine, Inosine Monophosphate, Inosine Nucleotides, Lactates, Male, Muscle Contraction, Muscles, Phosphocreatine, Rats

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