The DOI matches its Crossref record.
Dynamic state of collagen: pathways of collagen degradation in vivo and their possible role in regulation of collagen mass
Abstract
There is now evidence that collagen turnover in normal tissues can occur at rapid rates. In skin of adult rats, the mean rate lies between 3 and 5%/day, but rates of greater than 10%/day have been reported in some tissues, such as lung and periodontal ligament. The major sites of this degradation are still uncertain. Intracellular degradation, which occurs within minutes of synthesis, may be extensive, but its magnitude varies between tissues. This process may have evolved to allow the adaptive advantages of rapid turnover without compromising the supportive role of fibrillar collagen. There is now abundant evidence that changes in collagen degradation play an important role in the regulation of collagen mass. Increased breakdown of extracellular collagens may be required whether the mass is increased or decreased. However, preliminary evidence suggests that the degradation of newly synthesized collagen may be up- or down-regulated, depending on the direction of the change in content.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Westermann, D., Lindner, D., Kasner, M., Zietsch, C., Savvatis, K., Escher, F., von Schlippenbach, J., Skurk, C., Steendijk, P., Riad, A., et al. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.931451 · Cited by 644
Effect of Estrogen on Musculoskeletal Performance and Injury Risk
Chidi-Ogbolu, N., & Baar, K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01834 · Cited by 389
Meiners, S., Eickelberg, O., & Königshoff, M. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186914 · Cited by 340
Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications
Ali, M., Bathaei, M. J., Istif, E., Karimi, S. N. H., & Beker, L. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300318 · Cited by 211
Saini, K., Cho, S., Dooling, L. J., & Discher, D. E. (2020) · Matrix Biology · doi:10.1016/j.matbio.2019.06.001 · Cited by 90
Siadat, S. M., & Ruberti, J. W. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.01.025 · Cited by 87
Helling, A. L., Tsekoura, E. K., Biggs, M., Bayon, Y., Pandit, A., & Zeugolis, D. I. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00563 · Cited by 68
Kwiatkowski, M., Wurlitzer, M., Krutilin, A., Kiani, P., Nimer, R., Omidi, M., Mannaa, A., Bussmann, T., Bartkowiak, K., Kruber, S., et al. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2015.12.029 · Cited by 43
Rolewska, P., Al-Robaiy, S., Navarrete Santos, A., Simm, A., Silber, R.-E., & Bartling, B. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2012.04.012 · Cited by 25
Metadata
- Authors
- Laurent, G. J.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1987-01-01
- Volume
- 252
- Issue
- 1
- Pages
- C1-C9
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2266058855
- Cited by
- 385
- References
- 0
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
