The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Muscle transplantation between young and old rats: age of host determines recovery
Abstract
As compared with age-matched controls, extensor digitorum longus (EDL) muscles autografted in young rats regenerated significantly greater mass (1.8 times) and developed greater maximum contractile force (2.6 times) than EDL muscles autografted in old rats. A cross-age transplantation study showed that the mass and maximum force of old muscles grafted into young hosts were not significantly different from those of young muscles grafted into the same young hosts. Conversely, young muscle grafted into old hosts regenerated no better than old muscles grafted into the same old hosts. We conclude 1) that chronological age alone is not a factor that limits the intrinsic ability of a muscle to regenerate and 2) that the poor regeneration of muscles in old animals is a function of the environment for regeneration provided by the old host.
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In the citing paper
“Grafting experiments, in which portions of intact muscle tissues are heterochronically transplanted between young and aged mice, provided the first indication that the chronological age of the muscle microenvironment exerts a profound influence on muscle regenerative capacity32.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [32]
In the citing paper
“Extrinsic signals from old niches appear to dominate over intrinsic function of young stem cells in transplantation experiments143,144. By contrast, signals from young niches may have only limited rejuvenation effects on old stem cells, at least for HSCs145.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [143]
In the citing paper
“Skeletal muscle possesses the remarkable ability to repair and regenerate after an injury or damage; however, this ability is impaired with aging (4–7).”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [6]
Citations
Cites
SATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683
Skeletal muscle satellite cells: Changes in proliferation potential as a function of age
Schultz, E., & Lipton, B. H. (1982) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(82)90105-1 · Cited by 335
Age‐related differences in absolute numbers of skeletal muscle satellite cells
Gibson, M. C., & Schultz, E. (1983) · Muscle & Nerve · doi:10.1002/mus.880060807 · Cited by 327
Snow, M. H. (1977) · The Anatomical Record · doi:10.1002/ar.1091880206 · Cited by 223
The effects of aging on satellite cells in skeletal muscles of mice and rats
Snow, M. H. (1977) · Cell and Tissue Research · doi:10.1007/bf00220299 · Cited by 201
Edström, L., & Larsson, L. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016773 · Cited by 152
Reinnervation of long-term denervated rat muscle freely grafted into an innervated limb
Carlson, B. M., & Faulkner, J. A. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90077-5 · Cited by 83
Self-citationThe Influence of Age on the Course of Reinnervation of Muscle
Drahota, Z., & GUTMANN, E. (2009) · Gerontologia · doi:10.1159/000211047 · Cited by 49
A rapid silver impregnation for central and peripheral nerve fibers in paraffin and frozen sections
Goshgarian, H. G. (1977) · Experimental Neurology · doi:10.1016/0014-4886(77)90065-6 · Cited by 46
Womble, M. D., & Carlson, B. M. (1986) · American Journal of Anatomy · doi:10.1002/aja.1001760208 · Cited by 26
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Cellular and Molecular Regulation of Muscle Regeneration
CHARGÉ, S. B. P., & Rudnicki, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00019.2003 · Cited by 2,691
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Myogenic satellite cells: physiology to molecular biology
Hawke, T. J., & Garry, D. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.534 · Cited by 1,646
The aged niche disrupts muscle stem cell quiescence
Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851
No place like home: anatomy and function of the stem cell niche
Jones, D. L., & Wagers, A. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2319 · Cited by 830
Metadata
- Authors
- Carlson, B. M., & Faulkner, J. A.
- Affiliations
- University of Michigan (US)
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1989-06-01
- Volume
- 256
- Issue
- 6
- Pages
- C1262-C1266
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2323748919
- Cited by
- 417
- References
- 11
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 18 · 2018: 8 · 2017: 21 · 2016: 19 · 2015: 22 · 2014: 23 · 2013: 25 · 2012: 22
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-06157)
- National Eye Institute (EY-05813)
- National Institute of Dental and Craniofacial Research (DE 07687)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- muscle transplantation, muscle regeneration, aging, host age, extensor digitorum longus, autograft, muscle mass, age-related muscle loss
- MeSH terms
- Aging, Animals, Isometric Contraction, Male, Microscopy, Electron, Muscle Contraction, Muscles, Rats, Inbred Strains, Transplantation, Autologous, Muscle Development, Rats
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