SATELLITE CELL OF SKELETAL MUSCLE FIBERS
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When aged and young MuSCs are compared in equivalent in vivo repair settings, aged MuSCs show intrinsic changes that reduce self-renewal and repair capacity.
“The prospective isolation methods described above enabled recent findings demonstrating that MuSCs from aged tissues accumulate intrinsic changes that lead to a reduction in self-renewal and repair capacity, relative to young tissues, when placed in equivalent in vivo repair settings22,25,29,55,56 (Fig. 3).”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [22]
Muscle regeneration is primarily mediated by muscle stem cells or satellite cells (SCs), which reside in a characteristic niche located between the basal lamina and plasma membrane of myofibers.
“Muscle regeneration is primarily mediated by muscle stem cells or satellite cells (SCs), which reside in a characteristic niche located between the basal lamina and plasma membrane of myofibers12.”
From In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche (2021) · cites this paper as [12]
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- Authors
- Mauro, A.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Mauro, Alexander
- ORCID
- Mauro, Alexander
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1961-02-01
- Volume
- 9
- Issue
- 2
- Pages
- 493-495
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2225012
- OpenAlex
- W2087803244
- Cited by
- 3,683
- References
- 1
- Citations by year
- 2026: 72 · 2025: 96 · 2024: 114 · 2023: 119 · 2022: 154 · 2021: 176 · 2020: 177 · 2019: 151 · 2018: 166 · 2017: 153 · 2016: 148 · 2015: 159 · 2014: 161 · 2013: 152 · 2012: 170
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- satellite cells, skeletal muscle fibers, muscle regeneration, myogenesis, muscle stem cells
- MeSH terms
- Muscles, Muscle Fibers, Skeletal, Myoblasts
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