The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes
Abstract
Although nitric oxide (.N = O) biosynthesis is inducible in rat hepatocytes (HC), the physiological significance of .N = O production by these cells is unknown. Short exposure of HC to authentic .N = O led to a concentration-dependent inhibition of mitochondrial aconitase, NADH-ubiquinone oxidoreductase, and succinate-ubiquinone oxidoreductase (complexes I and II of the mitochondrial electron transport chain). Most susceptible to .N = O inhibition was mitochondrial aconitase, in which a reduction in enzyme activity to 20.2 +/- 1.6% of control was observed. In contrast to mitochondrial aconitase, cytosolic aconitase activity was not inhibited by .N = O. After exposure to a maximal inhibitory concentration of .N = O, mitochondrial aconitase activity recovered completely within 6 h. Complex I did not fully recover within this incubation period. Endogenous .N = O biosynthesis was induced in HC by a specific combination of cytokines and lipopolysaccharide. After 18 h of incubation with these stimuli, a significant inhibition of mitochondrial aconitase activity to 70.8 +/- 2.4% of controls was detected. However, this was due only in part to the action of .N = O. A non- .N = O-dependent inhibition of mitochondrial function appeared to be mediated by tumor necrosis factor.
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Cites
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Nitric oxide: A cytotoxic activated macrophage effector molecule
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Self-citationMacrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate
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Self-citationCurran, R. D., Billiar, T. R., Stuehr, D. J., Hofmann, K., & Simmons, R. L. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.5.1769 · Cited by 399
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Self-citationDefective oxidative metabolism of rat liver mitochondria in hemorrhagic and endotoxin shock
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Fridman, G., Friedman, G., Gutsol, A., Shekhter, A. B., Vasilets, V. N., & Fridman, A. (2008) · Plasma Processes and Polymers · doi:10.1002/ppap.200700154 · Cited by 2,084
Jha, A. K., Huang, S. C.-C., Sergushichev, A., Lampropoulou, V., Ivanova, Y., Loginicheva, E., Chmielewski, K., Stewart, K. M., Ashall, J., Everts, B., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.005 · Cited by 2,066
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606
El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218599110 · Cited by 1,191
Metadata
- Authors
- Stadler, J., Billiar, T. R., Curran, R. D., Stuehr, D. J., Ochoa, J. B., & Simmons, R. L.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1991-05-01
- Volume
- 260
- Issue
- 5
- Pages
- C910-C916
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2407737746
- Cited by
- 396
- References
- 15
- FWCI
- 14.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stadler, J., Billiar, T. R., Curran, R. D., Stuehr, D. J., Ochoa, J. B., & Simmons, R. L. (1991). Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1991.260.5.c910
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