The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells
Abstract
Guanosine-3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (cGMP-PK) plays a central role in the mediation of the vasodilator response to nitric oxide (NO) and other nitrovasodilators. It is unclear whether cGMP-PK affects calcium-activated potassium channels (KCa channels) or any other type of ion channel in smooth muscle. We provide here the first direct evidence that cGMP-PK can activate KCa channels in arterial smooth muscle cells. We demonstrate that NO and a membrane-permeable analogue of cGMP can activate KCa channels in on-cell patches approximately twofold. Furthermore, cGMP-PK, in the presence of ATP and cGMP added directly to the intracellular surface of inside-out patches, increases channel activity by approximately eightfold. These results suggest that cGMP-PK-mediated activation of KCa channels may contribute to the actions of NO and other nitrovasodilators.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Archer, S. L., Huang, J. M., Hampl, V, Nelson, D. P., Shultz, P. J., & Weir, E. K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7583 · Cited by 819
Estrogen as a Neuroprotectant in Stroke
Hurn, P. D., & Macrae, I. M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200004000-00001 · Cited by 401
Local Regulation of Microvascular Perfusion
Davis, M. J., Hill, M. A., & Kuo, L. (2008) · Microcirculation · doi:10.1016/b978-0-12-374530-9.00006-1 · Cited by 78
Metadata
- Authors
- Robertson, B. E., Schubert, R., Hescheler, J., & Nelson, M. T.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1993-07-01
- Volume
- 265
- Issue
- 1
- Pages
- C299-C303
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2256724151
- Cited by
- 618
- References
- 1
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Robertson, B. E., Schubert, R., Hescheler, J., & Nelson, M. T. (1993). cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1993.265.1.c299
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
