The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents
Abstract
Recent work has indicated that oxygen-sensing mechanism(s) resembling those controlling erythropoietin production operate in many non-erythropoietin-producing cells. To pursue the implication that such a system might control other genes, we studied oxygen-regulated expression of mRNAs for vascular endothelial growth factor, platelet-derived growth factor (PDGF) A and B chains, placental growth factor (PLGF), and transforming growth factor in four different cell lines and compared the characteristics with those of erythropoietin regulation. Oxygen-regulated expression was demonstrated for each gene in at least one cell type. However, the response to hypoxia (1% oxygen) varied markedly, ranging from a 13-fold increase (PDGF-B in Hep G2 cells) to a 2-fold decrease (PLGF in the trophoblastic line BeWo). For each gene/cell combination, both the magnitude and direction of the response to hypoxia were mimicked by exposure to cobaltous ions or two different iron-chelating agents, desferrioxamine and hydroxypyridinones. These similarities with established characteristics of erythropoietin regulation indicate that a similar mechanism of oxygen sensing is operating on a variety of vascular growth factors, and they suggest that chelatable iron is closely involved in the mechanism.
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Cites
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
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Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.
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PLATELET-DERIVED GROWTH FACTOR
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Self-citationMaxwell, P. H., Pugh, C. W., & Ratcliffe, P. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2423 · Cited by 411
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Cited by
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
Regulation of angiogenesis by hypoxia: role of the HIF system
Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520
Self-citationWhy is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
Carreau, A., Hafny‐Rahbi, B. E., Matejuk, A., Grillon, C., & Kieda, C. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01258.x · Cited by 1,246
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Metadata
- Authors
- Gleadle, J. M., Ebert, B. L., Firth, J. D., & Ratcliffe, P. J.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1995-06-01
- Volume
- 268
- Issue
- 6
- Pages
- C1362-C1368
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W1912376315
- Cited by
- 270
- References
- 14
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gleadle, J. M., Ebert, B. L., Firth, J. D., & Ratcliffe, P. J. (1995). Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1995.268.6.c1362
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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