General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works

Molecular Cloning: A Laboratory Manual

Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311 · see citing works

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,834 · see citing works

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617 · see citing works

The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology

Aziz, F., & Chaudhary, K. R. (2016) · Cardiorenal Medicine · doi:10.1159/000450796 · Cited by 3,285 · see citing works

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617 · see citing works

Erythropoietin: structure, control of production, and function

JELKMANN, W. E. B. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.2.449 · Cited by 1,167 · see citing works

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

Goldberg, M. A., Dunning, S. P., & Bunn, H. F. (1988) · Science · doi:10.1126/science.2849206 · Cited by 1,032 · see citing works

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5680 · Cited by 990 · see citing works

A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation

Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447-5454.1992 · Cited by 951 · see citing works

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

Kourembanas, S., Marsden, P. A., McQuillan, L. P., & Faller, D. V. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115367 · Cited by 684 · see citing works

A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti

Gilles‐Gonzalez, M., Ditta, G. S., & Helinski, D. R. (1991) · Nature · doi:10.1038/350170a0 · Cited by 477 · see citing works

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

Maxwell, P. H., Pugh, C. W., & Ratcliffe, P. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2423 · Cited by 411 · see citing works

Cascade regulation of nif gene expression in Rhizobium meliloti

David, M., Daveran‐Mingot, M., Batut, J., Dedieu, A., Domergue, O., Ghai, J., Hertig, C. M., Boistard, P., & Kahn, D. (1988) · Cell · doi:10.1016/s0092-8674(88)80012-6 · Cited by 409 · see citing works

Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells.

Kourembanas, S., Hannan, R. L., & Faller, D. V. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114759 · Cited by 386 · see citing works

Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface.

Shreeniwas, R., Koga, S., Karakurum, M., Pinsky, D. J., Kaiser, E., Brett, J., Wolitzky, B. A., Norton, C. R., Plocinski, J. M., & Benjamin, W. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116122 · Cited by 335 · see citing works

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.

Pugh, C. W., Tan, C., Jones, R. W., & Ratcliffe, P. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10553 · Cited by 255 · see citing works

Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.

Semenza, G. L., Koury, S. T., Nejfelt, M. K., Gearhart, J. D., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8725 · Cited by 248 · see citing works

Localization of cells producing erythropoietin in murine liver by in situ hybridization [see comments]

Koury, S. T., Bondurant, M. C., Koury, M., & Semenza, G. (1991) · Blood · doi:10.1182/blood.v77.11.2497.bloodjournal77112497 · Cited by 220 · see citing works

Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements.

Blanchard, K. L., Acquaviva, A. M., Galson, D. L., & Bunn, H. F. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5373 · Cited by 215 · see citing works

Enhancer element at the 3'-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene

Beck, I., Ramirez, S., Weinmann, R. S., & Caro, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98438-3 · Cited by 206 · see citing works

Erythropoietin.

Krantz, S. B. (1991) · PubMed · Cited by 206 · see citing works

Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events

Goldberg, M., Gaut, C., & Bunn, H. F. (1991) · Blood · doi:10.1182/blood.v77.2.271.271 · Cited by 199 · see citing works

The FixL protein of Rhizobium meliloti can be separated into a heme-binding oxygen-sensing domain and a functional C-terminal kinase domain.

Monson, E. K., Weinstein, M. B., Ditta, G. S., & Helinski, D. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4280 · Cited by 163 · see citing works

Polycythemia in transgenic mice expressing the human erythropoietin gene.

Semenza, G. L., Traystman, M. D., Gearhart, J. D., & Antonarakis, S. E. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2301 · Cited by 131 · see citing works

Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements.

Semenza, G. L., Dureza, R. C., Traystman, M. D., Gearhart, J. D., & Antonarakis, S. E. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.3.930 · Cited by 119 · see citing works

Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells

Webster, K. A. (1987) · Molecular and Cellular Biochemistry · doi:10.1007/bf00230147 · Cited by 105 · see citing works

Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein.

Beru, N., Smith, D. J., & Goldwasser, E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77273-6 · Cited by 50 · see citing works

Hypoxic Induction of the Human Erythropoietin Gene: Cooperation between the Promoter and Enhancer, Each of Which Contains Steroid Receptor Response Elements

Blanchard, K. L., Acquaviva, A., Galson, D. L., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5373-5385.1992 · Cited by 38 · see citing works

Human Erythropoietin Gene Expression in Transgenic Mice: Multiple Transcription Initiation Sites and cis-Acting Regulatory Elements

Semenza, G. L., Dureza, R. C., Traystman, M. D., Gearhart, J. D., & Antonarakis, S. E. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.3.930-938.1990 · Cited by 18 · see citing works

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981 · see citing works

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · see citing works

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works

Regulation of Mammalian O ₂ Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · see citing works

Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1

Semenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752 · see citing works

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature · doi:10.1038/nature06905 · Cited by 1,614 · see citing works

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386 · see citing works

Hypoxic control of metastasis

Rankin, E. B., & Giaccia, A. J. (2016) · Science · doi:10.1126/science.aaf4405 · Cited by 1,340 · see citing works

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

Jiang, B. H., Semenza, G. L., Bauer, C., & Marti, H. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.4.c1172 · Cited by 1,213 · see citing works

Cellular adaptation to hypoxia: O ₂ ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O ₂ ‐regulated gene expression

Wenger, R. H. (2002) · The FASEB Journal · doi:10.1096/fj.01-0944rev · Cited by 1,135 · see citing works

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

Jiang, B.-H., Rue, E., Wang, G. L., Roe, R., & Semenza, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17771 · Cited by 1,106 · see citing works

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Dewhirst, M. W., Cao, Y., & Moeller, B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2397 · Cited by 1,022 · see citing works

AH RECEPTOR SIGNALING PATHWAYS

Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899 · see citing works

Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia

Guzy, R. D., & Schumacker, P. T. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033506 · Cited by 881 · see citing works

Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

Lee, P. J., Jiang, B.-H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L., & Choi, A. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5375 · Cited by 782 · see citing works

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

Wang, G., & Semenza, G. (1993) · Blood · doi:10.1182/blood.v82.12.3610.3610 · Cited by 766 · see citing works

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

Soeda, A., Park, M., Lee, D., Mintz, A., Androutsellis-Theotokis, A., McKay, R. D., Engh, J., Iwama, T., Kunisada, T., Kassam, A. B., et al. (2009) · Oncogene · doi:10.1038/onc.2009.252 · Cited by 656 · see citing works

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00440-07 · Cited by 658 · see citing works

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

Caniggia, I., Mostachfi, H., Winter, J., Gassmann, M., Lye, S. J., Kuliszewski, M., & Post, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8316 · Cited by 644 · see citing works

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

Jiang, B.-H., Zheng, J. Z., Leung, S. W., Roe, R., & Semenza, G. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19253 · Cited by 629 · see citing works

JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

Gerald, D., Berra, E., Frapart, Y. M., Chan, D. A., Giaccia, A. J., Mansuy, D., Pouysségur, J., Yaniv, M., & Mechta-Grigoriou, F. (2004) · Cell · doi:10.1016/j.cell.2004.08.025 · Cited by 588 · see citing works

Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

Cullinan, S. B., & Diehl, J. A. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.09.018 · Cited by 554 · see citing works

Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors

Sitkovsky, M., & Lukashev, D. (2005) · Nature Reviews Immunology · doi:10.1038/nri1685 · Cited by 518 · see citing works

The effect of HIF on metabolism and immunity

Taylor, C. T., & Scholz, C. C. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00587-8 · Cited by 517 · see citing works

Proline hydroxylation and gene expression

Kaelin, W. G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133142 · Cited by 468 · see citing works

Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1

Rolfs, A., Kvietikova, I., Gassmann, M., & Wenger, R. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.20055 · Cited by 401 · see citing works

Identification of a hypoxia response element in the transferrin receptor gene

Lok, C. N., & Ponka, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24147 · Cited by 380 · see citing works

Oxygen and Placental Development During the First Trimester: Implications for the Pathophysiology of Pre-eclampsia

Caniggia, I., Winter, J., Lye, S. J., & Post, M. (2000) · Placenta · doi:10.1053/plac.1999.0522 · Cited by 377 · see citing works

Neuroglobin protects the brain from experimental stroke <i>in</i> <i>vivo</i>

Sun, Y., Jin, K., Peel, A., Mao, X. O., Xie, L., & Greenberg, D. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0637726100 · Cited by 354 · see citing works

Anaemia in kidney disease: harnessing hypoxia responses for therapy

Koury, M. J., & Haase, V. H. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.82 · Cited by 313 · see citing works

Mechanisms of hypoxia signalling: new implications for nephrology

Schödel, J., & Ratcliffe, P. J. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0182-z · Cited by 309 · see citing works

Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer

Ratcliffe, P. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.251470 · Cited by 294 · see citing works

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target

Serocki, M., Bartoszewska, S., Janaszak-Jasiecka, A., Ochocka, R. J., Collawn, J. F., & Bartoszewski, R. (2018) · Angiogenesis · doi:10.1007/s10456-018-9600-2 · Cited by 288 · see citing works

Pharmacologic Targeting of Hypoxia-Inducible Factors

Semenza, G. L. (2019) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021637 · Cited by 288 · see citing works

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

Cam, H., Easton, J. B., High, A., & Houghton, P. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.030 · Cited by 266 · see citing works

Targeting hypoxia-inducible factors: therapeutic opportunities and challenges

Yuan, X., Ruan, W., Bobrow, B., Carmeliet, P., & Eltzschig, H. K. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00848-6 · Cited by 245 · see citing works

Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes

Lolmède, K., Durand de Saint Front, V, Galitzky, J., Lafontan, M., & Bouloumié, A. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802407 · Cited by 224 · see citing works

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron

Singhal, R., Mitta, S. R., Das, N. K., Kerk, S. A., Sajjakulnukit, P., Solanki, S., Andren, A., Kumar, R., Olive, K. P., Banerjee, R., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143691 · Cited by 215 · see citing works

Role of the hypoxia inducible factors HIF in iron metabolism

Peyssonnaux, C., Nizet, V., & Johnson, R. S. (2008) · Cell Cycle · doi:10.4161/cc.7.1.5145 · Cited by 217 · see citing works

Cutting Edge: Hypoxia-Inducible Factor 1α and Its Activation-Inducible Short Isoform I.1 Negatively Regulate Functions of CD4+ and CD8+ T Lymphocytes

Lukashev, D., Klebanov, B., Kojima, H., Grinberg, A., Ohta, A., Berenfeld, L., Wenger, R. H., Ohta, A., & Sitkovsky, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.4962 · Cited by 208 · see citing works

Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine

Melillo, G., Taylor, L. S., Brooks, A., Musso, T., Cox, G. W., & Varesio, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.12236 · Cited by 201 · see citing works

EPAS1 trans-activation during hypoxia requires p42/p44 MAPK

Conrad, P. W., Freeman, T. L., Beitner-Johnson, D., & Millhorn, D. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33709 · Cited by 178 · see citing works

The mechanism of Warburg effect-induced chemoresistance in cancer

Liu, C., Jin, Y., & Fan, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.698023 · Cited by 177 · see citing works

Oxygen sensing in yeast: Evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes

Kwast, K. E., Burke, P. V., Staahl, B. T., & Poyton, R. O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5446 · Cited by 175 · see citing works

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

Shah, Y. M., Ito, S., Morimura, K., Chen, C., Yim, S., Haase, V. H., & Gonzalez, F. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.009 · Cited by 168 · see citing works

Ero1-Lα plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer

May, D., Itin, A., Gal, O., Kalinski, H., Feinstein, E., & Keshet, E. (2005) · Oncogene · doi:10.1038/sj.onc.1208325 · Cited by 167 · see citing works

Hypoxia-inducible factors and diabetes

Gunton, J. E. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137556 · Cited by 159 · see citing works

The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability

Jaśkiewicz, M., Moszyńska, A., Króliczewski, J., Cabaj, A., Bartoszewska, S., Charzyńska, A., Gebert, M., Dąbrowski, M., Collawn, J. F., & Bartoszewski, R. (2022) · Cellular &amp; Molecular Biology Letters · doi:10.1186/s11658-022-00408-7 · Cited by 143 · see citing works

Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1β (IL-1β) in astrocyte cultures

Zhang, W., Petrovic, J.-M., Callaghan, D., Jones, A., Cui, H., Howlett, C., & Stanimirovic, D. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.01.014 · Cited by 125 · see citing works

Hypoxia and the phenomenon of immune exclusion

Pietrobon, V., & Marincola, F. M. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-020-02667-4 · Cited by 119 · see citing works

Progress toward Overcoming Hypoxia-Induced Resistance to Solid Tumor Therapy

Reginato, M., & Karakashev, S. (2015) · Cancer Management and Research · doi:10.2147/cmar.s58285 · Cited by 95 · see citing works

Oxygen Sensing in Retinal Health and Disease

Lange, C. A. K., & Bainbridge, J. W. B. (2012) · Ophthalmologica · doi:10.1159/000331418 · Cited by 86 · see citing works

Hypoxia Alters Iron-regulatory Protein-1 Binding Capacity and Modulates Cellular Iron Homeostasis in Human Hepatoma and Erythroleukemia Cells

Toth, I., Yuan, L., Rogers, J. T., Boyce, H., & Bridges, K. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.7.4467 · Cited by 91 · see citing works

miR-429 regulates the transition between hypoxia-inducible factor (HIF)1A and HIF3A expression in human endothelial cells

Janaszak-Jasiecka, A., Bartoszewska, S., Kochan, K., Piotrowski, A., Kalinowski, L., Kamysz, W., Ochocka, R. J., Bartoszewski, R., & Collawn, J. F. (2016) · Scientific Reports · doi:10.1038/srep22775 · Cited by 81 · see citing works

Treatment with HIF-1α Antagonist PX-478 Inhibits Progression and Spread of Orthotopic Human Small Cell Lung Cancer and Lung Adenocarcinoma in Mice

Jacoby, J. J., Erez, B., Korshunova, M. V., Williams, R. R., Furutani, K., Takahashi, O., Kirkpatrick, L., Lippman, S. M., Powis, G., O'Reilly, M. S., et al. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181dc211f · Cited by 84 · see citing works

Hydroxylase Inhibition Abrogates TNF-α–Induced Intestinal Epithelial Damage by Hypoxia-Inducible Factor-1–Dependent Repression of FADD

Hindryckx, P., De Vos, M., Jacques, P., Ferdinande, L., Peeters, H., Olievier, K., Bogaert, S., Brinkman, B., Vandenabeele, P., Elewaut, D., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002541 · Cited by 73 · see citing works

Adrenomedullin is a novel adipokine: adrenomedullin in adipocytes and adipose tissues

Li, Y., Jiang, C., Wang, X., Zhang, Y., Shibahara, S., & Takahashi, K. (2007) · Peptides · doi:10.1016/j.peptides.2007.03.005 · Cited by 71 · see citing works

The hypoxia‐induced changes in <scp>miRNA‐mRNA</scp> in <scp>RNA</scp> ‐induced silencing complexes and <scp>HIF</scp> ‐2 induced <scp>miRNAs</scp> in human endothelial cells

Moszyńska, A., Jaśkiewicz, M., Serocki, M., Cabaj, A., Crossman, D. K., Bartoszewska, S., Gebert, M., Dąbrowski, M., Collawn, J. F., & Bartoszewski, R. (2022) · The FASEB Journal · doi:10.1096/fj.202101987r · Cited by 53 · see citing works

Clinicopathological and prognostic significance of hypoxia-inducible factor-1α in esophageal squamous cell carcinoma: a meta-analysis

Ping, W., Sun, W., Zu, Y., Chen, W., & Fu, X. (2014) · Tumor Biology · doi:10.1007/s13277-013-1579-0 · Cited by 36 · see citing works

Role of Hypoxia-Inducible Factor 1α in T Cells as a Negative Regulator in Development of Vascular Remodeling

Kurobe, H., Urata, M., Ueno, M., Ueki, M., Ono, S., Izawa-Ishizawa, Y., Fukuhara, Y., Lei, Y., Ripen, A. M., Kanbara, T., et al. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.192666 · Cited by 35 · see citing works

Multifaceted Interplay between Hormones, Growth Factors and Hypoxia in the Tumor Microenvironment

Lappano, R., Todd, L. A., Stanic, M., Cai, Q., Maggiolini, M., Marincola, F., & Pietrobon, V. (2022) · Cancers · doi:10.3390/cancers14030539 · Cited by 32 · see citing works

Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi

Chung, D., Haas, H., & Cramer, R. A. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00381 · Cited by 29 · see citing works

Regulation of the HIF switch in human endothelial and cancer cells

Slawski, J., Jaśkiewicz, M., Barton, A., Kozioł, S., Collawn, J. F., & Bartoszewski, R. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151386 · Cited by 26 · see citing works

Specific inhibition of HIF activity: can peptides lead the way?

Mylonis, I., Chachami, G., & Simos, G. (2021) · Cancers · doi:10.3390/cancers13030410 · Cited by 21 · see citing works

HIF1α is not a target of 14q deletion in clear cell renal cancer

Shenoy, N. (2020) · Scientific Reports · doi:10.1038/s41598-020-74631-7 · Cited by 14 · see citing works

Challenges in mimicking hypoxia: insights into HIF-regulated MiRNA expression induced by DMOG and CoCl2

Barton, A., Jaśkiewicz, M., Więch -Walów, A., Moszyńska, A., Cabaj, A., Wielockx, B., Schaefer, L., Collawn, J. F., & Bartoszewski, R. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02459-7 · Cited by 14 · see citing works

Conserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia

Brown, A. N., Anderson, M. T., Smith, S. N., Bachman, M. A., & Mobley, H. L. T. (2023) · mBio · doi:10.1128/mbio.01448-23 · Cited by 14 · see citing works

Hypoxia Sensing in Resident Cardiac Macrophages Regulates the Arg1 Macrophage Lineage During Ischemic Heart Injury

Kadyrov, F. F., Koenig, A. L., Amrute, J. M., Dun, H., Li, W., Weinheimer, C. J., Nigro, J. M., Kovacs, A., Bredemeyer, A. L., Lai, L., et al. (2022) · doi:10.1101/2022.08.04.502542 · Cited by 3 · see citing works

Supplementary Data from MSF-A Interacts with Hypoxia-Inducible Factor-1α and Augments Hypoxia-Inducible Factor Transcriptional Activation to Affect Tumorigenicity and Angiogenesis

Amir, S., Wang, R., Matzkin, H., et al. (2023) · doi:10.1158/0008-5472.22366220

Hypoxia-inducible factor-2α-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization

Paliege, A., Rosenberger, C., Bondke, A., Sciesielski, L. K., Shina, A., Heyman, S. N., Flippin, L. A., Arend, M., Klaus, S. J., & Bachmann, S. (2009) · Kidney International · doi:10.1038/ki.2009.460 · Cited by 169 · see citing works

VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α

Yue, Y., Tang, Y., Huang, H., Zheng, D., Liu, C., Zhang, H., Liu, Y., Li, Y., Sun, X., & Lu, L. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104829 · Cited by 17 · see citing works

Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy

Wu, Y., Li, Z., McDonough, M. A., Schofield, C. J., & Zhang, X. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00415 · Cited by 44 · see citing works

Transcriptional regulation of hypoxia inducible factors alpha (HIF-α) and their inhibiting factor (FIH-1) of channel catfish (Ictalurus punctatus) under hypoxia

Geng, X., Feng, J., Liu, S., Wang, Y., Arias, C. R., & Liu, Z. (2014) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2013.12.007 · Cited by 101 · see citing works