Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice
Abstract
The membrane electrical properties of diaphragm and extensor digitorum longus (EDL) muscle fibers of dystrophic mdx and control mice from 4 wk to 14-19 mo of age were recorded with the intracellular microelectrode technique. Up to 8 wk of age, the diaphragm and EDL muscles did not differ between the two strains. From 8 up to 20 wk, the mdx diaphragm fibers showed a higher membrane resistance (Rm), which was due to significantly lower values of resting chloride conductance (GCl) and an overexcitability with respect to age-matched controls. Oppositely, the mdx EDL muscle fibers had significantly lower Rm and higher GCl values than age-related controls at 8, 10, and 13 wk, along with a decreased membrane excitability. These differences were no longer detectable at 20 wk. The diaphragm and EDL muscles from 14- to 19-mo-old controls showed a decrease of GCl and an increase of potassium conductance with respect to adult animals. In aged mdx animals, these changes were very dramatic in diaphragm fibers, whereas no differences, with respect to adults, were found in the EDL muscle. Thus GCl is an index of the dystrophic condition of mdx muscles. In the degenerating diaphragm, the impairment of GCl can account for some of the pathological features of the muscle. In the EDL muscle, the changes of GCl can follow the high regenerative potential of the hindlimb muscles of the mdx phenotype.
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These findings are in contrast to the effect of leptin administration on increased natriuresis and sympathetic activity in normal, nonobese leptin-resistant Zucker rats.
“These findings are in contrast to the effect of leptin administration on increase natriuresis (49, 50) and sympathetic activity (51) in normal, nonobese leptin-resistant Zucker rats (51).”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [50]
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- Authors
- De Luca, A., Pierno, S., & Camerino, D. C.
- Affiliations
- Department of Pharmacobiology, Faculty of Pharmacy, University ofBari, Italy.
- University of Bari Aldo Moro (IT)
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1997-01-01
- Volume
- 272
- Issue
- 1
- Pages
- C333-C340
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W146737824
- Cited by
- 92
- References
- 24
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 1 · 2013: 2
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Keywords
- Duchenne muscular dystrophy, mdx mice, diaphragm, extensor digitorum longus, membrane resistance, potassium conductance, membrane excitability, muscle degeneration, muscle regeneration, age-related changes
- MeSH terms
- Aging, Animals, Diaphragm, Electric Conductivity, Electrophysiology, Ions, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Muscular Dystrophy, Animal, Toes, Muscle, Skeletal, Muscle Fibers, Skeletal, Mice
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