Cited by 163Pregnancy and preeclampsia studiesBirth, Development, and HealthGestational Diabetes Research and Management

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Impaired mitochondrial function in human placenta with increased maternal adiposity

Open access

Mele, James, Muralimanoharan, Sribalasubashini, Maloyan, Alina, Myatt, Leslie·2014·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00025.2014PMC PMC4154072

Open this paper in CoChat — free account

Abstract

The placenta plays a key role in regulation of fetal growth and development and in mediating in utero developmental programming. Obesity, which is associated with chronic inflammation and mitochondrial dysfunction in many tissues, exerts a programming effect in pregnancy. We determined the effect of increasing maternal adiposity and of fetal sex on placental ATP generation, mitochondrial biogenesis, expression of electron transport chain subunits, and mitochondrial function in isolated trophoblasts. Placental tissue was collected from women with prepregnancy BMI ranging from 18.5 to 45 following C-section at term with no labor. Increasing maternal adiposity was associated with excessive production of reactive oxygen species and a significant reduction in placental ATP levels in placentae with male and female fetuses. To explore the potential mechanism of placental mitochondrial dysfunction, levels of transcription factors regulating the expression of genes involved in electron transport and mitochondrial biogenesis were measured. Our in vitro studies showed significant reduction in mitochondrial respiration in cultured primary trophoblasts with increasing maternal obesity along with an abnormal metabolic flexibility of these cells. This reduction in placental mitochondrial respiration in pregnancies complicated by maternal obesity could compromise placental function and potentially underlie the increased susceptibility of these pregnancies to fetal demise in late gestation and to developmental programming.

Integrity signals

Registry

Crossref · 10.1152/ajpendo.00025.2014

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
The fetal and infant origins of adult disease.
Barker, D. J. (1990) · BMJ · doi:10.1136/bmj.301.6761.1111 · Cited by 2,768
Physiological Roles of Mitochondrial Reactive Oxygen Species
Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632
Assessing mitochondrial dysfunction in cells
Brand, M. D., & Nicholls, D. G. (2011) · Biochemical Journal · doi:10.1042/bj20110162 · Cited by 2,436
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality
Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
Ritov, V. B., Menshikova, E. V., He, J., Ferrell, R. E., Goodpaster, B. H., & Kelley, D. E. (2005) · Diabetes · doi:10.2337/diabetes.54.1.8 · Cited by 887
Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells
Rossignol, R., Gilkerson, R., Aggeler, R. J., Yamagata, K., Remington, S. J., & Capaldi, R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1101 · Cited by 871

Show all 65 references

Research works printed but not linked: 4

Lee HC, 2007, Exp Biol Med (Maywood), 232, 592
Pruis MG, Acta Physiol (Oxf)
Watson AL, 1998, J Clin Endocrinol Metab, 83, 1697
Yen SS, 1994, J Reprod Med, 39, 277

Sorted by citations

Items 101–163 of 163

The transformative potential of an integrative approach to pregnancy
Eidem, H. R., McGary, K. L., Capra, J. A., Abbot, P., & Rokas, A. (2017) · Placenta · doi:10.1016/j.placenta.2017.07.010 · Cited by 12
A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
Simon, B., Bucher, M., & Maloyan, A. (2017) · Journal of Visualized Experiments · doi:10.3791/56484 · Cited by 14
Self-citation
The impact of obesity on mitochondrial dysfunction during pregnancy
de Oliveira, M. P., da Silva, L. E., Fernandes, B. B., da Silva, M. R., Pistóia, D. G., Cichella, T. D. S., Jacinto, L. B., Spuldaro, K. M., Iser, B. P. M., & Rezin, G. T. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112463 · Cited by 13
Metformin Impacts Human Syncytiotrophoblast Mitochondrial Function from Pregnancies Complicated by Obesity and Gestational Diabetes Mellitus in a Sexually Dimorphic Manner
Hebert, J. F., & Myatt, L. (2023) · Antioxidants · doi:10.3390/antiox12030719 · Cited by 10
Self-citation
Influence of maternal obesity on the multi-omics profiles of the maternal body, gestational tissue, and offspring
Zhao, D., Liu, Y., Jia, S., He, Y., Wei, X., Liu, D., Ma, W., Luo, W., Gu, H., & Yuan, Z. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113103 · Cited by 9
Maternal high-fat, high-sucrose diet–induced excess adiposity is linked to placental hypoxia and disruption of fetoplacental immune homeostasis in late gestation
Bellissimo, C. J., Ribeiro, T. A., Yeo, E., Jazwiec, P. A., Luo, H., Bains, J., Kennedy, K. M., Bowdish, D. M. E., & Sloboda, D. M. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf143 · Cited by 10
Enhanced Placental Mitochondrial Respiration in Tibetan Women at High Altitude
Liu, H., Tenzing, N., van Patot, M. C. T., Qile, M., Ge, R., & Wuren, T. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.697022 · Cited by 7
Syncytialization and prolonged exposure to palmitate impacts BeWo respiration
Easton, Z. J. W., Delhaes, F., Mathers, K. E., Zhao, L., Vanderboor, C., & Regnault, T. R. H. (2020) · Reproduction · doi:10.1530/rep-19-0433 · Cited by 8
Tropomyosin Receptor Kinase B Agonist, 7,8-Dihydroxyflavone, Improves Mitochondrial Respiration in Placentas From Obese Women
Prince, C. S., Maloyan, A., & Myatt, L. (2017) · Reproductive Sciences · doi:10.1177/1933719117716776 · Cited by 10
Self-citation
Plasma Acylcarnitines during Pregnancy and Neonatal Anthropometry: A Longitudinal Study in a Multiracial Cohort
Song, Y., Lyu, C., Li, M., Rahman, M. L., Chen, Z., Zhu, Y., Hinkle, S. N., Chen, L., Mitro, S. D., Li, L., et al. (2021) · Metabolites · doi:10.3390/metabo11120885 · Cited by 9
Vascular malperfusion and abruption are prevalent in placentas from pregnancies with congenital heart disease and not associated with cardiovascular risk
Altendahl, M., Mok, T., Adimkpayah, E., Goldstein, J., Lin, J. P., & Afshar, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-28011-6 · Cited by 8
Maternal phenotype: how do age, obesity and diabetes affect myometrial function?
Prendergast, C. E. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.10.016 · Cited by 8
Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner
Kelly, A. C., Chan, J., Powell, T. L., Cox, L. A., Jansson, T., & Rosario, F. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1178533 · Cited by 10
Genome-wide transcriptome profiling of crop plants
Parveen, R., Jain, T., Parveen, R., & Singh, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95989-6.00018-8 · Cited by 7
Macrophage Switching in Pregnancy: Regulatory Mechanisms Governing Term Labour and Preterm Birth
Prakash, G. R., Vaidhya, A., Deepthi, V., Rathore, L. S., Panigrahi, M., Madhu, C. L., Singh, T. U., & Parida, S. (2025) · American Journal of Reproductive Immunology · doi:10.1111/aji.70123 · Cited by 8
An Integrated Multi-OMICS Approach Highlights Elevated Non-Esterified Fatty Acids Impact BeWo Trophoblast Metabolism and Lipid Processing
Easton, Z. J. W., Sarr, O., Zhao, L., Buzatto, A. Z., Luo, X. F., Zhao, S., Li, L., & Regnault, T. R. H. (2023) · Metabolites · doi:10.3390/metabo13080883 · Cited by 7
Maternal physical activity significantly alters the placental transcriptome
Loiselle, J. J., Fatica, T., Tzaneva, V., Vuong, N., Holčı́k, M., & Adamo, K. B. (2020) · Placenta · doi:10.1016/j.placenta.2020.08.016 · Cited by 8
Impacts of maternal excess adiposity on the uterine immune environment: contributions to placental dysfunction and adverse pregnancy outcomes
Bellissimo, C. J., Beristain, A. G., & Sloboda, D. M. (2025) · Reproduction · doi:10.1530/rep-24-0464 · Cited by 8
The impact of obesity on placental vascular development and function
Ramanlal, I., James, J. L., & Boss, A. L. (2026) · Molecular Human Reproduction · doi:10.1093/molehr/gaag002 · Cited by 7
Effect of SARS-CoV-2 Infection and COVID-19 Vaccination on Oxidative Status of Human Placenta: A Preliminary Study
Macáková, K., Pšenková, P., Šupčíková, N., Vlková, B., Celec, P., & Záhumenský, J. (2023) · Antioxidants · doi:10.3390/antiox12071403 · Cited by 6
Sex-Specific Dysregulation of Placental Lipid Metabolism in Preeclampsia
Mishra, J. S., Zhao, H., Zheng, J. J., & Kumar, S. (2024) · Obstetrics and Gynecology Research · doi:10.26502/ogr0159 · Cited by 6
Cryopreserved placental biopsies maintain mitochondrial activity for high-resolution respirometry
Giovarelli, M., Serati, A., Zecchini, S., Guelfi, F., Clementi, E., & Mandò, C. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00645-2 · Cited by 6
Excessive backfat of sows at mating promotes oxidative stress and up-regulates mitochondrial-mediated apoptotic pathway in the full-term placenta
Liang, T., Wen, A. Y., Dong, S. S., Xiao, K., Li, H., & Yan, P. (2019) · Livestock Science · doi:10.1016/j.livsci.2019.02.012 · Cited by 10
Mitochondrial dynamics, biogenesis, mitophagy and oxidative stress in gestational obesity: A review
Rodríguez-Córdoba, K. M., Agreda-Soto, S., Garzón, J. A. C., & Pustovrh, M. C. (2024) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2024.100205 · Cited by 7
Early-Life Nutritional Determinants of Pediatric MASLD
DiStefano, J. K. (2025) · Nutrients · doi:10.3390/nu17243871 · Cited by 6
Increased proline intake during gestation alleviates obesity-related impaired fetal development and placental function in gilts
Huang, S., Li, J., Ye, H., Huang, Z., Wu, J., Liu, L., Ma, S., Luo, H., Wei, T., Liu, K., et al. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.10.007 · Cited by 5
Modulation of Autophagy Through Regulation of 5’-AMP-Activated Protein Kinase Affects Mitophagy and Mitochondrial Function in Primary Human Trophoblasts
Yang, H.-Q., Chandra, Y., & Zhang, Z.-Y. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00495-5 · Cited by 5
Influence of maternal obesity on human trophoblast differentiation: The role of mitochondrial status
Hernández, M. H., Santos, E. D., Rodriguez, Y., Priou, C., Berveiller, P., Vialard, F., & Dieudonné, M. (2022) · Reproductive Biology · doi:10.1016/j.repbio.2022.100650 · Cited by 5
Inflammasomes in the Pathophysiology of Maternal Obesity: Potential Therapeutic Targets to Reduce Long-Term Adverse Health Outcomes in the Mother and Offspring
Murthi, P., & Rajaraman, G. (2020) · Current Vascular Pharmacology · doi:10.2174/1570161118666200603131536 · Cited by 5
Placental structure, function and mitochondrial phenotype relate to fetal size and sex in micePreprint
Salazar‐Petres, E., Carvalho, D. P., López‐Tello, J., & Sferruzzi-Perri, A. N. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.22.453249 · Cited by 5
Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes
Kadam, L., Chan, K., Tawater, E., & Myatt, L. (2025) · Placenta · doi:10.1016/j.placenta.2025.09.019 · Cited by 4
Self-citation
Basic Structure of a Placental Villus
Burton, G. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-84725-8_6 · Cited by 5
Maternal-fetal hepatic and placental metabolome profiles are associated with reduced fetal growth in a rat model of maternal obesity
Mumme, K., Gray, C. L., Reynolds, C. M., Vickers, M. H., Harrison, C. J., Stanley, J. L., Ruggiero, K., Villas-Bôas, S. G., Baker, P. N., & Sulek, K. (2016) · Metabolomics · doi:10.1007/s11306-016-1014-9 · Cited by 4
The Role of Placental Inflammasomes in Linking the Adverse Effects of Maternal Obesity on Fetal Development
Aye, I. L. M. H., Lager, S., & Powell, T. L. (2015) · Springer eBooks · doi:10.1007/978-3-319-16853-1_6 · Cited by 5
Hyperglycemia enhances group B Streptococcus pathogenicity by impairing TLR2 expression and chemotactic response in the human placenta
Jiménez‐Escutia, R., Villafuerte-Pérez, A., Vargas-Alcantar, D., Martínez-Garfias, K., Rodríguez‐Flores, S., Velázquez-Sánchez, P., Fortanel‐Fonseca, A., Zamora‐Escudero, R., Islas‐López, M., Mancilla‐Herrera, I., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1610381 · Cited by 3
Maternal exercise alters placental proteome in an exercise mode-specific manner
Jevtovic, F., Wisseman, B., Jahan, F., Claiborne, A., Collier, D. N., DeVente, J., Mouro, S., Zeczycki, T. N., Szumilewicz, A., Adamo, K. B., et al. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00052.2025 · Cited by 4
Maternal Complications of Pregnancy that Affect Fetal Development
Longo, L. D. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7483-2_11 · Cited by 3
Maternal Obesity: Impacts on the Cardiovascular Health of Mother and Offspring
Jahan, F., Bagchi, A. K., & Bagchi, R. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-47336-5_3 · Cited by 2
Influence of gestational weight gain on placental oxidative stress in women with normal pre-pregnancy body mass indexPreprint
Santos-Rosendo, C., Mateos, R. M., Vázquez-Fonseca, L., Ábalos-Martínez, J., Olmedo-Iglesias, H., Jimenez, V. M., Fajardo‐Expósito, M. A., Bugatto, F., & Visiedo, F. (2022) · Research Square · doi:10.21203/rs.3.rs-2255163/v1 · Cited by 2
Sex-Dependent Epigenomic and Transcriptomic Reprogramming Links Maternal Obesity to Cardiac Remodeling in Adult OffspringPreprint
Wilson, T. D., Philips, E. A., Alharithi, Y. J., Broberg, C., Vanderpool, J., Rakshe, S. K., Fei, S. S., Davis, B. A., Koch, S. E., Zhu, Z., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.15.648971 · Cited by 2
Self-citation
Maternal Obesity Modulates Cord Blood Concentrations of Proprotein Convertase Subtilisin/Kexin-type 9 Levels
Rallis, D., Papathanasiou, A. E., & Christou, H. A. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae031 · Cited by 1
Mechanistic target of rapamycin signaling activity in the human placenta across gestation and in maternal obesity
Bidne, K. L., Erickson, K., Powell, T. L., & Jansson, T. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf007 · Cited by 1
Fetal erythropoiesis and hemoglobin regulation in the context of maternal obesity
Kou, Z., Hossain, M. N., Chen, L. W., Islam, S., Li, X., Shin, C., Cui, Q., de Avila, J. M., Zhu, M.-J., & Du, ‬. (2025) · Blood Red Cells & Iron · doi:10.1016/j.brci.2025.100018 · Cited by 1
Role of RGS12 in placental mitochondrial dysfunction and adverse pregnancy outcomes
Cao, X., Zhou, X., Xu, N., Shi, W., Huang, H., Sun, Z., Chen, S., & Xu, C.-M. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05999-w · Cited by 1
Associations between physical activity, sedentary behavior, body mass index and changes in placental structure and vascularization – data from the FitMum randomized controlled trial
Jensen, I. K. B., Kummer, D., Roland, C. B., Siwetz, M., Knudsen, S. D. P., Jessen, A. D., Bendix, J. M., Mølsted, S., Desoyé, G., Stallknecht, B. M., et al. (2026) · Placenta · doi:10.1016/j.placenta.2026.03.018 · Cited by 1
Maternal overnutrition and mitochondrial function
Nitert, M. D., Siow, S. M., & Holland, O. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813862-5.00011-6 · Cited by 1
Diet Induced Maternal Hypercholesterolemia and In Utero Fetal Programming
Jayalekshmi, V. S., & Ramachandran, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-35358-2_15 · Cited by 1
Composite neonatal and maternal morbidities with small- versus appropriate- for gestational age among uncomplicated obese women undergoing repeat cesarean delivery*
Haidar, Z. A., Viteri, O. A., Nasab, S. H., Moussa, H. N., Sibai, B. M., & Whitty, J. E. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1384808
Autophagy and Fetal Programming
Maloyan, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805253-2.00019-5
Self-citation
Quantifying Mid-pregnancy Placental Metabolism in Guinea Pigs Fed a Lifelong Western Diet
Empey, M.-E. E. T. (2020) · Scholarship@Western (Western University)
Pregnancy Outcome and Metabolic Syndrome
Ottanelli, S., Simeone, S., Serena, C., Rambaldi, M. P., Zullino, S., & Mecacci, F. (2021) · ISGE series · doi:10.1007/978-3-030-63650-0_13
Lipopolysaccharide induces placental mitochondrial dysfunction by reducing MNRR1 levels via a TLR4-independent pathwayPreprint
Purandare, N., Kunji, Y., Xi, Y., Romero, R. J., Gomez‐Lopez, N., Fribley, A. M., Grossman, L. I., & Aras, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.06.467519
Faculty Opinions recommendation of Developmental programming of mitochondrial biology: a conceptual framework and review.
Gunnar, M. R. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737847338.793583368
Maternal Obesity Programs Cardiac Remodeling in Offspring Via Epigenetic, Metabolic, and Immune DysregulationsPreprint
Philips, E. A., Alharithi, Y. J., Wilson, T. D., Broberg, C., Davis, B. A., Koch, S. E., Carbone, L., Rubinstein, J. H., Gurley, S. B., Kumar, S., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5228904
Self-citation
Associations between maternal lipid metabolism and immune characteristics in children with autism spectrum disorder
He, J., Liao, S., Luo, B., & Huang, Y. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116833
Maternal obesity alters adipogenic potential and mitochondrial maximal respiration in infant mesenchymal stem cells
Paz, H. A., Zhong, Y., Williams, D. K., Shankar, K., Andres, A., & Wankhade, U. D. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1786389
Mémoire épigénétique des trajectoires pondérales maternelles préconceptionnelles au cours du développement et à long terme
Panchenko, P. E. (2015) · theses.fr (ABES) · doi:10.70675/1c8455acza5c1z427fzb7c6z5b17ad36641e
Impact de l’obésité maternelle sur les fonctions placentaires : rôles de la leptine et de l'adiponectine
Nogues, P. (2019) · theses.fr (ABES) · doi:10.70675/c3ecfee5ze428z4395za563za025758f71a2
Maternal lifetime stress and placental mitochondrial DNA mutational load: Effect modification by maternal characteristics
Carroll, K. N., Lesseur, C., Brunst, K., Colicino, E., Chiu, Y., Hartman, T. J., Coull, B., & Wright, R. J. (2026) · Placenta · doi:10.1016/j.placenta.2026.06.013
Mitochondrial Dysfunction: A Critical Link Between Maternal Diet and Offspring Metabolic Health
Shao, C., Lin, H., Yu, J., Chen, H., Ren, Y., Ren, J., Zeng, Y., Wu, Y., Zhang, Q., & Xiao, X. (2026) · Biomolecules · doi:10.3390/biom16081106
Maternal obesity disrupts trophoblast differentiation and causes female-specific labyrinth defects in the mouse placenta
Chen, L. W., Kou, Z., Hossain, M. N., Shin, C., Islam, S., Li, X., de Avila, J. A., & Du, ‬. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00357.2026
Maternal Diglyceride Diet Attenuates Selected Metabolic Effects of Maternal High‐Fat Feeding in Offspring via Energy Metabolism and Microbiota Modulation
Wu, Q., Li, C., Song, S., Wang, H., Zhao, R., Sun, L., Shang, B., & Geng, Y. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.72427
Maternal late-pregnancy BMI is associated with compartment-specific immune-metabolic signatures across the maternal–placental–fetal axis
Schuch, V., Bashi, A., Hossack, D. J., Adékambi, T., Joseph, T. T., Wilson, C., Olanrewaju, R. A., Dawning, A., Johnson, A., Jones, S., et al. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1899628

Authors: Mele, J., Muralimanoharan, S., Maloyan, A., & Myatt, L.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Myatt, Leslie
ORCID: Maloyan, Alina
Myatt, Leslie
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2014-09-01
Volume: 307
Issue: 5
Pages: E419-E425
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00025.2014
PMC: PMC4154072
OpenAlex: W2060301363
Semantic Scholar: fed5ec549bf327c45f840b6f1ffe832e4f50b1d0
Cited by: 163
References: 65
Citations by year: 2026: 9 · 2025: 14 · 2024: 10 · 2023: 13 · 2022: 15 · 2021: 18 · 2020: 18 · 2019: 17 · 2018: 12 · 2017: 11 · 2016: 13 · 2015: 11 · 2014: 1
FWCI: 12.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (UL1TR001120, KL2TR001118)
National Heart, Lung, and Blood Institute (HL075297, R01HL075297)
National Center for Research Resources (UL1RR025767)
National Center for Advancing Translational Sciences
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD076259)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords: maternal obesity, placenta, mitochondrial dysfunction, mitochondrial biogenesis, electron transport chain, trophoblast, ATP production, reactive oxygen species, fetal sex, developmental programming, prepregnancy BMI, mitochondrial respiration, metabolic flexibility, placental function
MeSH terms: Adenosine Triphosphate, Adult, Cells, Cultured, Chorionic Villi, Energy Metabolism, Female, Humans, Male, Mitochondria, Obesity, Placenta, Pregnancy, Pregnancy Complications, Body Mass Index, Reactive Oxygen Species, Adiposity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impaired mitochondrial function in human placenta with increased maternal adiposity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks