The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-δ
Abstract
The mechanisms of the impairment in hepatic glucose metabolism induced by free fatty acids (FFAs) and the importance of FFA oxidation in these mechanisms remain unclear. FFA-induced peripheral insulin resistance has been linked to membrane translocation of novel protein kinase C (PKC) isoforms, but the role of PKC in hepatic insulin resistance has not been assessed. To investigate the biochemical pathways that are induced by FFA in the liver and their relation to glucose metabolism in vivo, we determined endogenous glucose production (EGP), the hepatic content of citrate (product of acetyl-CoA derived from FFA oxidation and oxaloacetate), and hepatic PKC isoform translocation after 2 and 7 h Intralipid + heparin (IH) or SAL in rats. Experiments were performed in the basal state and during hyperinsulinemic clamps (insulin infusion rate, 5 mU · kg−1· min−1). IH increased EGP in the basal state ( P < 0.001) and during hyperinsulinemia ( P < 0.001) at 2 and 7 h. Also, 7-h infusion of IH induced resistance to the suppressive effect of insulin on EGP ( P < 0.05). Glycerol infusion (resulting in plasma glycerol levels similar to IH infusion) did not have any effect on EGP. IH increased hepatic citrate content by twofold, independent of the insulin levels and the duration of IH infusion. IH induced hepatic PKC-δ translocation from the cytosolic to membrane fraction in all groups. PKC-δ translocation was greater at 7 compared with 2 h ( P < 0.05). In conclusion, 1) increased FFA oxidation may contribute to the FFA-induced increase in EGP in the basal state and during hyperinsulinemia but is not associated with FFA-induced hepatic insulin resistance, and 2) the progressive insulin resistance induced by FFA in the liver is associated with a progressive increase in hepatic PKC-δ translocation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“increased intramyocellar levels of fat metabolites, for example, FACoA and DAG, which are strong activators of protein kinase C, have been demonstrated following lipid infusion [176].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [176]
Citations
Cites
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Lewis, G. F., Carpentier, A. C., Adeli, K., & Giacca, A. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0461 · Cited by 1,370
Self-citationDresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311
Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267
Effect of fatty acids on glucose production and utilization in man.
Ferrannini, E., Barrett, E. J., Bevilacqua, S., & DeFronzo, R. A. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111133 · Cited by 1,050
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
Kelley, D. E., & Mandarino, L. J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.677 · Cited by 1,017
Finegood, D. T., Bergman, R. N., & Vranić, M. (1987) · Diabetes · doi:10.2337/diab.36.8.914 · Cited by 546
Research works printed but not linked: 2
- 10.1152/ajpendo.1992.263.6.E1063 · DOI
- Chen S, 1999, Diabetes, 48, A225
Cited by
Sorted by citations
Items 101–194 of 194
Cerebrolysin improves sciatic nerve dysfunction in a mouse model of diabetic peripheral neuropathy
Jia, F., Dong, H.-Y., Jiang, X., Niu, C., Du, L., & Feng, J. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.175063 · Cited by 27
Obesity, Insulin Resistance and Hepatic Perfusion
Brock, R. W., & Dorman, R. B. (2007) · Microcirculation · doi:10.1080/10739680701282986 · Cited by 27
Charbonneau, A., Melançon, A., Lavoie, C., & Lavoie, J.-M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00570.2004 · Cited by 27
Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease
Iyer, A., Brown, L., Whitehead, J. P., Prins, J. B., & Fairlie, D. P. (2015) · The FASEB Journal · doi:10.1096/fj.15-271155 · Cited by 25
Review article: The role of adipose tissue in uraemia‐related insulin resistance
Manolescu, B. N., Stoian, I. A.-M., Atanasiu, V., Buşu, C., & Lupescu, O. (2008) · Nephrology · doi:10.1111/j.1440-1797.2008.01022.x · Cited by 26
Cheng, P., Feng, I., Chen, J.-J., Kuo, H., Lee, P., Yu, M., Chiu, Y., Chiu, H., Chien, S., Chen, P., et al. (2023) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17765 · Cited by 25
Hoffman, R. P. (2006) · Diabetes Care · doi:10.2337/dc06-2460 · Cited by 24
Chijimatsu, T., Umeki, M., Kataoka, Y., Kobayashi, S., Yamada, K., Oda, H., & Mochizuki, S. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.08.070 · Cited by 23
Tang, C., Marchand, K., Lam, L., Lux-Lantos, V. A., Thyssen, S. M., Guo, J., Giacca, A., & Arany, E. J. (2013) · Reproduction · doi:10.1530/rep-12-0388 · Cited by 23
Self-citationMitani, T., Takaya, T., Harada, N., Katayama, S., Yamaji, R., Nakamura, S., & Ashida, H. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.04.001 · Cited by 23
Fat-induced liver insulin resistance
Shah, P., Basu, A., & Rizza, R. A. (2003) · Current Diabetes Reports · doi:10.1007/s11892-003-0066-1 · Cited by 23
Shiwa, M., Yoneda, M., Okubo, H., Ohno, H., Kobuke, K., Monzen, Y., Kishimoto, R., Nakatsu, Y., Asano, T., & Kohno, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135554 · Cited by 22
Badi, R. M., Mostafa, D. G., Khaleel, E. F., & Satti, H. H. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13074 · Cited by 22
Ragheb, R., Medhat, A. M., Shanab, G. M. L., Seoudi, D. M., & Fantus, I. G. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.044 · Cited by 22
Self-citationCentral Obesity and Elevated Liver Enzymes
Lam, G. M., & Mobarhan, S. (2004) · Nutrition Reviews · doi:10.1111/j.1753-4887.2004.tb00010.x · Cited by 22
Greene, M. W., Burrington, C. M., Luo, Y., Ruhoff, M. S., Lynch, D. T., & Chaithongdi, N. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.10.008 · Cited by 21
Ghrelin Signaling in Immunometabolism and Inflamm-Aging
Fang, C., Xu, H., Guo, S., Mertens‐Talcott, S. U., & Sun, Y. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1286-1_9 · Cited by 21
Stout, M. B., Liu, L., & Belury, M. A. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000413 · Cited by 21
He, B., Piao, D., Yu, C., Wang, Y., & Han, P. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0997-9 · Cited by 19
PKCδ regulates hepatic triglyceride accumulation and insulin signaling in Leprdb/db mice
Zhang, J., Burrington, C. M., Davenport, S. K., Johnson, A. K., Horsman, M. J., Chowdhry, S., & Greene, M. W. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.07.048 · Cited by 19
He, B., Zhao, S., Zhang, W., Li, Y., Lü, Y., & Han, P. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.04.004 · Cited by 17
He, B., Liu, L., Yu, C., Wang, Y., & Han, P. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1342-7 · Cited by 17
Protein kinase C δ-dependent regulation of Ubiquitin-proteasome system function in breast cancer
Sun, S., Wu, Q., Song, J., & Sun, S. (2017) · Cancer Biomarkers · doi:10.3233/cbm-170451 · Cited by 16
Luo, Y., Woodie, L. N., Graff, E. C., Zhang, J., Fowler, S., Wang, X., Wang, X., O’Neill, A. M., & Greene, M. W. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109174 · Cited by 16
Kim, K., Kim, H. Y., Son, E., Heo, J., & Cheong, J. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.03.019 · Cited by 14
Duration of rise in free fatty acids determines salicylate's effect on hepatic insulin sensitivity
Pereira, S., Yu, W., Frigolet, M. E., Beaudry, J. L., Shpilberg, Y., Park, E., Dirlea, C., Nyomba, B. L. G., Riddell, M. C., Fantus, I. G., et al. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0214 · Cited by 13
Self-citationGrueter, C. A., Edgerton, D. S., Donahue, E. P., Vaughan, S., Chu, C. A., Sindelar, D. K., & Cherrington, A. D. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2006 · Cited by 13
He, B., Chen, L., Yu, C., Piao, D., Wang, Y., & Han, P. (2013) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.09.019 · Cited by 13
Aziz, A. A., Anderson, G. H., Giacca, A., & Cho, F. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00850.2004 · Cited by 12
Self-citationWan, X.-D., Yang, W.-B., Xia, Y., Wang, J., Lu, T., & Wang, X. M. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03346485 · Cited by 13
Effect of sodium salicylate on oxidative stress and insulin resistance induced by free fatty acids.
He, B., Zhao, S., Zhang, W., Li, Y., & Han, P. (2010) · PubMed · Cited by 12
Puljak, L., Pagliassotti, M. J., Wei, Y., Qadri, I., Parameswara, V., Esser, V., Fitz, J., & Kilic, G. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080333 · Cited by 12
Mai, K., Kullmann, V., Bobbert, T., Maser‐Gluth, C., Möhlig, M., Bähr, V., Pfeiffer, A. F. H., Spranger, J., & Diederich, S. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02362.x · Cited by 12
Pathways Involved In Lipid-Induced Insulin Resistance In Obesity
Watt, M. J., & Steinberg, G. R. (2007) · Future Lipidology · doi:10.2217/17460875.2.6.659 · Cited by 11
Oleate-induced decrease in hepatocyte insulin binding is mediated by PKC-δ
Chen, S., Lam, T. K. T., Park, E., Burdett, E., Wang, P. Y. T., Wiesenthal, S. R., Lam, L., Tchipashvili, V., Fantus, I. G., & Giacca, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.190 · Cited by 11
Self-citationProtein kinase C inhibitors: a patent review (2010 – present)
Sobhia, M. E., Grewal, B. K., Paul, M. L. S., Patel, J. A., Kaur, A., Haokip, T., & Kokkula, A. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.812073 · Cited by 10
Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues
Kojima, K., Motoshima, H., Tsutsumi, A., Igata, M., Matsumura, T., Kondo, T., Kawashima, J., Ichinose, K., Furukawa, N., Inukai, K., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.007 · Cited by 10
Metabolic drivers of MASLD and MASH: from hormonal imbalance to fibrosis
Gastaldelli, A., Scoditti, E., & Macedo, M. P. (2026) · Diabetologia · doi:10.1007/s00125-026-06774-7 · Cited by 11
Somvanshi, P. R., Patel, A. K., Bhartiya, S., & Venkatesh, K. V. (2016) · RSC Advances · doi:10.1039/c5ra18128c · Cited by 9
Mechanisms underlying fat-induced hepatic insulin resistaNce
Park, E., & Giacca, A. (2007) · Future Lipidology · doi:10.2217/17460875.2.5.503 · Cited by 9
Self-citationEffects of excess salt and fat intake on myocardial function and infarct size in rat
Mozaffari, M. S., Patel, C., Ballas, C., & Schaffer, S. W. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.08.014 · Cited by 9
Acute elevation of free fatty acids impairs hepatic glucose uptake in conscious rats
Nakahara, I., Matsuhisa, M., Shiba, Y., Kuroda, A., Nakatani, Y., Hatazaki, M., Kajimoto, Y., Kubota, M., Yamasaki, Y., & Hori, M. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.02.016 · Cited by 9
Boden, G. H. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-141-3_4 · Cited by 8
Monti, L. D., Genzano, C. B., Fontana, B., Galluccio, E., Spadoni, S., Magistro, A., Bosi, E., & Piatti, P. (2021) · Endocrine · doi:10.1007/s12020-021-02868-x · Cited by 8
Ruderman, N. B., & Shulman, G. I. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00044-7 · Cited by 7
Ruderman, N. B., & Shulman, G. I. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00043-3 · Cited by 7
Garrel, G., Rouch, C., L’Hôte, D., Tazi, S., Kassis, N., Giton, F., Dairou, J., Dournaud, P., Gressèns, P., Magnan, C., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.877999 · Cited by 4
Fat Metabolism in Insulin Resistance and Type 2 Diabetes
Duez, H., & Lewis, G. F. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-043-4_4 · Cited by 4
Grobelna, M., Strauss, E., & Krasiński, Z. (2019) · Polish Journal of Cardio-Thoracic Surgery · doi:10.5114/kitp.2019.88602 · Cited by 4
Rypka, M., Červenková, K., Uherková, L., Poczatková, H., Bogdanová, K., & Veselý, J. (2005) · Biomedical Papers · doi:10.5507/bp.2005.034 · Cited by 4
Salah-Eldin, A.-E., Mahalel, U. A., & Hamed, A. I. (2007) · Natural Product Communications · doi:10.1177/1934578x0700200805 · Cited by 4
Obesity and Disease: Insulin Resistance, Diabetes, Metabolic Syndrome and Polycystic Ovary Syndrome
Proietto, J. (2005) · Wiley eBooks · doi:10.1002/9780470987087.ch13 · Cited by 4
Impact of Brain Fatty Acid Signaling on Peripheral Insulin Action in Mice
Neschen, S., Wu, M., Fuchs, C., Kondofersky, I., Theis, F. J., de Angelis, M. H., Häring, H., & Sartorius, T. (2018) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0735-9533 · Cited by 3
Insulin and the Physiology of Carbohydrate Metabolism
Pereira, S., & Giacca, A. (2011) · Energy balance and cancer · doi:10.1007/978-1-4419-9911-5_1 · Cited by 3
Self-citationLee, H., Park, M.-K., Lee, K. I., An, Y.-J., Kim, J. M., Park, J. Y., Han, Y. S., Hong, S. H., Choi, S.-S., Yoo, Y. H., et al. (2007) · The Journal of Korean Diabetes Association · doi:10.4093/jkda.2007.31.1.63 · Cited by 3
Kinase-dependent pathways and the development of insulin resistance in hepatocytes
Rondinone, C. M. (2007) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2.2.195 · Cited by 4
Metabolism and Gene Expression in Liver Regeneration
(2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48529-x_8 · Cited by 2
Tissue Specific-Metabolism of Lipids for Ectopic Deposition
Kim, M. (2011) · The Korean Journal of Obesity · doi:10.7570/kjo.2011.20.3.99 · Cited by 2
Targeting protein kinase C epsilon or theta as a therapeutic strategy for insulin resistance
Schmitz‐Peiffer, C. (2005) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2005.04.002 · Cited by 1
Type 2 Diabetes and Concomitant Illness
Dungan, K. M., Harris, E., & Braithwaite, S. S. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-043-4_14 · Cited by 1
Fat-Induced Insulin Resistance and Atherosclerosis
Boden, G. H. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-963-9_49 · Cited by 1
Heparin Effects on Serum Gonadotropins
Kohn, S. A., Fought, A. J., Kuhn, K., Sloggett, K. J., Bradford, A. P., Santoro, N. F., & Schauer, I. E. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab178 · Cited by 1
The Role of the Acute-Phase Proteins in the Development and Progression of Liver Diseases
Sanchez, M., Arturo, K. M. R., Espinar, G., Grobe, G., Jiménez, Á. A. G., & Misael, U. (2011) · InTech eBooks · doi:10.5772/20671 · Cited by 1
Linking Inflammation, Obesity, and Diabetes
McArdle, M. A., Kennedy, E. B., & Roche, H. M. (2023) · Springer eBooks · doi:10.1007/978-3-031-40116-9_29 · Cited by 1
Ogiso, K., Koriyama, N., Obo, T., Tokito, A., & Nishio, Y. (2020) · Diabetology International · doi:10.1007/s13340-020-00457-3 · Cited by 1
Thankam, F. G., Radwan, M. M., & Agrawal, D. K. (2020) · Springer eBooks · doi:10.1007/978-3-030-47336-5_13 · Cited by 1
The Effect of Fenofibrate and Exercise on Metabolic Syndrome and Hepatic Steatosis in OLETF Rats
Lee, K.-I., Kim, J. M., Park, J. Y., Kim, J. W., Mok, J. Y., Park, M., Lee, H., Hong, S. H., Li, W., & Kim, D. K. (2007) · Journal of Korean Endocrine Society · doi:10.3803/jkes.2007.22.3.192 · Cited by 1
P2Y6 receptor signaling in natural killer cells impairs insulin sensitivity in obesityPreprint
Sieben, A., Hausen, A. C., Klemm, P., Jaïs, A., Heilinger, C., Alber, J., Folz‐Donahue, K., Schumacher, L., Altmüller, J., Franitza, M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.23.449596 · Cited by 1
Shah, S., & Cox, A. G. (2009) · Biochemistry Insights · doi:10.4137/bci.s2996 · Cited by 1
Obesity Insulin Resistance and Gut Hormones
Proietto, J. (2009) · Wiley eBooks · doi:10.1002/9781444307627.ch14
Insulin Resistance, Diabetes and its Complications
Ng, D. S. (2006) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.200400011
Nutritional sensing and its utility in treating obesity
Amin, A., & Murphy, K. G. (2012) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.12.6
From Randle to Lipotoxicity Through Vranic
Giacca, A. (2010) · Canadian Journal of Diabetes · doi:10.1016/s1499-2671(10)43019-1
Self-citationHepatic CEACAM1 protects against metabolic abnormalities associated with metabolic syndrome.
Bowman, T. A. (2010) · OhioLink ETD Center (Ohio Library and Information Network)
Molecular mechanisms of development of cellular insulin resistance
Raksha, N., Savchuk, О., & Остапченко, Л. І. (2011) · Biopolymers and Cell · doi:10.7124/bc.000106
Progress in New Markers for Diabetes Inflammation
Pugia, M. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-21927-1_11
The Impact of Inflammation on the Determinants of Skeletal Muscle Glucose Uptake
Mulligan, K. X. (2012)
Regulation of Metabolism by Hepatic OXPHOS: A Dissertation
Akie, T. E. (2015) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/m2388v
Insulin Sensitivity is Enhanced by CGMP-mediated MAPK Inhibition in Rat Adipocytes
Thomas, G. (2010) · Library and Archives Canada (Government of Canada)
Metabolomics – Nutritional and Physiological Challenges
Suárez, M., Canela-Canela, N., Bas-Prior, J. M. D., Puiggròs, F., Arola, L., & Caimari, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.22826-6
Fatty Acids and Growth Regulation
(2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48529-x_4
Nutrient and Energy Metabolism in Cell Proliferation
(2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48529-x_3
Fatty Acids and Mitochondria, Cell Growth and Injury: Broader Implications
(2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48529-x_7
Mitochondrial Function in Cell Growth and Death
(2004) · Springer eBooks · doi:10.1007/0-306-48529-x_5
Linking Inflammation, Obesity, and Diabetes
McArdle, M. A., Kennedy, E. B., & Roche, H. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_29 · Cited by 1
Linking Inflammation, Obesity and Diabetes
McArdle, M. A., Kennedy, E. B., & Roche, H. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_29-1
Sosibo, S. C., Kruger, H. G., Nxumalo, W. P., & Zondi, Z. (2024) · Chemical Physics Impact · doi:10.1016/j.chphi.2024.100757
Étude de la sensibilité à l’insuline du tissu adipeux en absence de production hépatique de glucose
Casteras, S. (2012) · theses.fr (ABES) · doi:10.70675/7b0400e0z9e49z4df6za2c1z0c19ce63d0ca
Physiological Functions of Freshwater Clam Extracts and the Exploration of Their Bioactive Compounds
Kuwano, K., Hata, M., Umeki, M., Mochizuki, S., Oda, H., & Shimazoe, T. (2026) · Foods · doi:10.3390/foods15111870
Role of Protein Kinase C in Insulin Resistance and Metabolic Syndrome
Cruz-Villarreal, D. E., Hernández-González, K. D., & Olivares-Reyes, J. A. (2026) · Kinases and Phosphatases · doi:10.3390/kinasesphosphatases4030025
Insulinoodporność komórki wątrobowej
Daniluk, J., Zwolak, A., Jastrzębska, I., Sawicka, K., & Szczyrek, M. (2011)
Metadata
- Authors
- Lam, T. K. T., Yoshii, H., Haber, C. A., Bogdanovic, E., Lam, L., Fantus, I. G., & Giacca, A.
- Affiliations
- Departments of Physiology and
- University of Toronto (CA)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2002-10-01
- Volume
- 283
- Issue
- 4
- Pages
- E682-E691
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2042144976
- Cited by
- 195
- References
- 54
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 9
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- free fatty acids, hepatic insulin resistance, protein kinase C delta, endogenous glucose production, fatty acid oxidation, hyperinsulinemic-euglycemic clamp, Intralipid, heparin, glycerol infusion, hepatic glucose metabolism
- MeSH terms
- Animals, Blood Glucose, C-Peptide, Fatty Acids, Nonesterified, Female, Glycerol, Insulin Resistance, Isoenzymes, Liver, Oxidation-Reduction, Protein Kinase C, Triglycerides, Glucose Clamp Technique, Rats, Wistar, Rats, Protein Kinase C-delta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review