Lam, Tony K. T.

Hypothalamic KATP channels control hepatic glucose production

Pocai, A., Lam, T. K. T., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., & Rossetti, L. (2005) · Nature

Pancreatic function and diabetesRegulation of Appetite and Obesity

Cited by 645

Hypothalamic sensing of fatty acids

Lam, T. K. T., Schwartz, G. J., & Rossetti, L. (2005) · Nature Neuroscience

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 478

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 432

Metformin Activates a Duodenal Ampk-Dependent Pathway to Lower Hepatic Glucose Production in Rats

Duca, F. A., Côté, C. D., Rasmussen, B. A., Zadeh-Tahmasebi, M., Rutter, G. A., Filippi, B. M., & Lam, T. K. T. (2015) · Nature Medicine

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 402

Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism

Lam, T. K. T., Gutierrez-Juarez, R., Pocai, A., & Rossetti, L. (2005) · Science

Pancreatic function and diabetesRegulation of Appetite and Obesity

Cited by 341

Metformin alters upper small intestinal microbiota that impact a glucose-SGLT1-sensing glucoregulatory pathway

Bauer, P. V., Duca, F. A., Waise, T. M. Z., Rasmussen, B. A., Abraham, M. A., Dranse, H. J., Puri, A., O’Brien, C. A., & Lam, T. K. T. (2018) · Cell Metabolism

Gut microbiota and healthMetabolism, Diabetes, and Cancer

Cited by 265

Molecular disruption of hypothalamic nutrient sensing induces obesity

He, W., Lam, T. K. T., Obici, S., & Rossetti, L. (2006) · Nature Neuroscience

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 233

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-δ

Lam, T. K. T., Yoshii, H., Haber, C. A., Bogdanovic, E., Lam, L., Fantus, I. G., & Giacca, A. (2002) · American Journal of Physiology-Endocrinology and Metabolism

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 195

The metabolic role of vagal afferent innervation

Waise, T. M. Z., Dranse, H. J., & Lam, T. K. T. (2018) · Nature Reviews Gastroenterology & Hepatology

Regulation of Appetite and ObesityVagus Nerve Stimulation Research

Cited by 140

Neuronal regulation of homeostasis by nutrient sensing

Lam, T. K. T. (2010) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 125

Obesity and the kidney: mechanistic links and therapeutic advances

Yau, K., Kuah, R., Cherney, D. Z. I., & Lam, T. K. T. (2024) · Nature Reviews Endocrinology

Chronic Kidney Disease and DiabetesAdipokines, Inflammation, and Metabolic Diseases

Cited by 91

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

Yang, C. S., Lam, C. K. L., Chari, M., Cheung, G. W. C., Kokorovic, A., Gao, S., Leclerc, I., Rutter, G. A., & Lam, T. K. T. (2010) · Diabetes

Metabolism, Diabetes, and CancerRegulation of Appetite and Obesity

Cited by 86

A Balance of Lipid-Sensing Mechanisms in the Brain and Liver

Caspi, L., Wang, P. Y. T., & Lam, T. K. T. (2007) · Cell Metabolism

Regulation of Appetite and ObesityMetabolism, Diabetes, and Cancer

Cited by 58

Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance.

Chari, M., Lam, C. K. L., Wang, P. Y. T., & Lam, T. K. T. (2008) · Diabetes

Pancreatic function and diabetesRegulation of Appetite and Obesity

Cited by 53

A fatty acid-dependent hypothalamic–DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteins

Yue, J. T. Y., Abraham, M. A., LaPierre, M. P., Mighiu, P. I., Light, P. E., Filippi, B. M., & Lam, T. K. T. (2015) · Nature Communications

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 46