The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
Abstract
Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the criteria used to diagnose the disorder remain poorly defined. Localized proton magnetic resonance spectroscopy (MRS) accurately measures hepatic triglyceride content (HTGC) but has been used only in small research studies. Here, MRS was used to analyze the distribution of HTGC in 2,349 participants from the Dallas Heart Study (DHS). The reproducibility of the procedure was validated by showing that duplicate HTGC measurements were high correlated ( r = 0.99, P < 0.001) and that the coefficient of variation between measurements was low (8.5%). Intake of a high-fat meal did not significantly affect the measurements, and values were similar when measurements were made from the right and left hepatic lobes. To determine the “upper limit of normal” for HTGC, the distribution of HTGC was examined in the 345 subjects from the DHS who had no identifiable risk factors for hepatic steatosis (nonobese, nondiabetic subjects with minimal alcohol consumption, normal liver function tests, and no known liver disease). The 95th percentile of HTGC in these subjects was 5.56%, which corresponds to a hepatic triglyceride level of 55.6 mg/g. With this value as a cutoff, the prevalence of hepatic steatosis in Dallas County was estimated to be 33.6%. Thus MRS provides a sensitive, quantitative, noninvasive method to measure HTGC and, when applied to a large urban US population, revealed a strikingly high prevalence of hepatic steatosis.
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Cites
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Nonalcoholic Fatty Liver Disease
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Quantification of liver fat using magnetic resonance spectroscopy
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Rudovich, N. N., Weickert, M. O., Machann, J., & Pfeiffer, A. F. H. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.02.004 · Cited by 16
Liver triacylglycerol content and gestational diabetes: effects of moderate energy restriction
Hodson, K., Dalla Man, C., Smith, F. E., Barnes, A., McParlin, C., Cobelli, C., Robson, S. C., Araújo-Soares, V., & Taylor, R. (2017) · Diabetologia · doi:10.1007/s00125-016-4143-9 · Cited by 16
Willis, S. A., Malaikah, S., Bawden, S. J., Sherry, A. P., Sargeant, J. A., Coull, N. A., Bradley, C. R., Rowlands, A., Naim, I., Ennequin, G., et al. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15755 · Cited by 9
Zhyzhneuskaya, S. V., Al‐Mrabeh, A. H., Peters, C., Barnes, A. C., Hollingsworth, K. G., Welsh, P., Sattar, N., Lean, M. E. J., & Taylor, R. (2025) · Diabetic Medicine · doi:10.1111/dme.15462 · Cited by 6
Novel Antidiabetic Strategies and Diabetologists' Views in Nonalcoholic Steatohepatitis
Kahl, S., Pützer, J., & Roden, M. (2022) · Seminars in Liver Disease · doi:10.1055/s-0041-1732354 · Cited by 5
Metadata
- Authors
- Szczepaniak, L. S., Nurenberg, P., Leonard, D., Browning, J. D., Reingold, J. S., Grundy, S., Hobbs, H. H., & Dobbins, R. L.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2005-02
- Volume
- 288
- Issue
- 2
- Pages
- E462-E468
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2159469729
- Cited by
- 1,562
- References
- 6
- FWCI
- 21.38
- Type
- journal article
- Language
- en
- Open access
- closed
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