Quantification of liver fat using magnetic resonance spectroscopy
Abstract
Localized proton MR spectroscopy using stimulated echoes was used to quantify the liver fat concentration in patients with various degrees of fatty liver due to alcohol abuse. Ten patients underwent a liver biopsy followed by chemical triglyceride estimation of the fatty content. A statistically significant correlation was found between the fat concentration measured in the liver biopsies, and the concentration calculated from the spectroscopic experiments (r = 0.9, p < .001). Quantitative assessment of liver fat concentrations using localized spectroscopy is superior to methods based on differences in relaxation times, and can be used to estimate the fat concentration over the full range of fat content in contrast to the spectroscopic imaging methods. Localized spectroscopy may replace liver biopsy in the diagnosis of diffuse fatty infiltrations, and can be used for follow-up, due to its noninvasive nature.
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The measurement of liver fat by proton spectroscopy has been validated against histologically determined lipid content and against estimates of fatty degeneration or infiltration by x-ray computer-assisted tomography.
“This measurement has been validated against histologically determined lipid content 44 and against estimates of fatty degeneration or infiltration by x-ray computer-assisted tomography.38”
From Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) · cites this paper as [44]
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- Authors
- Thomsen, C., Becker, U., Winkler, K., Christoffersen, P., Jensen, M., & Henriksen, O.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Thomsen, Carsten
- Venue
- Magnetic Resonance Imaging
- Publisher
- Elsevier BV
- Published
- 1994-01
- Volume
- 12
- Issue
- 3
- Pages
- 487-495
- ISSN
- 0730-725X (ISSN-L)
- OpenAlex
- W2093071246
- Cited by
- 332
- References
- 37
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 17 · 2016: 7 · 2015: 15 · 2014: 15 · 2013: 18 · 2012: 17
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Keywords
- liver fat quantification, 1H NMR, stimulated echo, alcoholic fatty liver, liver biopsy, triglyceride content, non-invasive diagnosis
- MeSH terms
- Adult, Aged, Biopsy, Fatty Liver, Alcoholic, Female, Humans, Lipids, Liver, Male, Middle Aged, Magnetic Resonance Spectroscopy
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