Cited by 198Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesDiabetes Management and Research

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Minimal model estimation of glucose absorption and insulin sensitivity from oral test: validation with a tracer method

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Dalla Man, Chiara, Caumo, Andrea, Basu, Rita, Rizza, Robert, Toffolo, Gianna, Cobelli, Claudio·2004·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00319.2003

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Abstract

Measuring insulin sensitivity during the physiological milieu of oral glucose perturbation, e.g., a meal or an oral glucose tolerance test, would be extremely valuable but difficult since the rate of appearance of absorbed glucose is unknown. The reference method is a tracer two-step one: first, the rate of appearance of glucose (R a mealref) is reconstructed by employing the tracer-to-tracee ratio clamp technique with two tracers and a model of non-steady-state glucose kinetics; next, this R a mealref is used as the known input of a model describing insulin action on glucose kinetics to estimate insulin sensitivity (S Iref). Recently, a nontracer method based on the oral minimal model (OMM) has been proposed to estimate simultaneously the above quantities, denoted R a meal and S I, respectively, from plasma glucose and insulin concentrations measured after an oral glucose perturbation. This last method has obvious advantages over the tracer method, but its domain of validity has never been assessed against a reference method. It is thus important to establish whether or not the “nontracer” R a meal and S I compare well with the “tracer” R a mealref and S Iref . We do this comparison on a database of 88 subjects, and it is very satisfactory: R a meal profiles agree well with the R a mealref and correlation of S Iref with S I is r = 0.86 ( P < 0.0001). We conclude that OMM candidates as a reliable tool to measure both the rate of glucose absorption and insulin sensitivity from oral glucose tests without employing tracers.

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Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
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Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans
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“Finally, it is also of interest to compare OMM and reference SI with other indexes, such as the Homeostasis Model Assessment (HOMA) (15), the Quantitative Insulin Sensitivity Check Index (QUICKI) (11), and the insulin sensitivity index (ISI) of Matsuda-De Fronzo (12), frequently used to measure insulin sensitivity dur…”
Method
Quantitative estimation of insulin sensitivity.
Bergman, R. N., Ider, Y. Z., Bowden, C. R., & Cobelli, C. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.236.6.e667 · Cited by 1,874 · cited 3×
“This index, useful not only for diagnosis but also for assessing the efficacy of a given therapy, is usually measured using methods involving an intravenous administration of glucose and/or insulin, such as the glucose clamp technique (10) or the intravenous glucose tolerance test (IVGTT) interpreted with the minimal…”
MethodSelf-citation
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Authors: Dalla Man, C., Caumo, A., Basu, R., Rizza, R., Toffolo, G., & Cobelli, C.
Affiliations: University of Padua (IT)
ORCID: Caumo, Andrea
Basu, Rita
Toffolo, Gianna
Cobelli, Claudio
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2004-10
Volume: 287
Issue: 4
Pages: E637-E643
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00319.2003
OpenAlex: W2113594895
Semantic Scholar: 70f0547653f303f77c579b7da478c231e71203ad
Cited by: 198
References: 14
Citations by year: 2026: 5 · 2025: 7 · 2024: 6 · 2023: 13 · 2022: 9 · 2021: 11 · 2020: 7 · 2019: 12 · 2018: 6 · 2017: 11 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 15 · 2012: 14
FWCI: 3.73
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Padua Research Archive (University of Padova) (submittedVersion, other-oa)
Funders: National Institutes of Health (RR-00585)
National Institute on Aging (AG14383, P01AG014383)
National Institute of Biomedical Imaging and Bioengineering (EB 01975, P41EB001975)
National Center for Research Resources (RR-00585, M01RR000585)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: oral minimal model, insulin sensitivity, oral glucose tolerance test
MeSH terms: Absorption, Algorithms, Blood Glucose, Carbon Isotopes, Deuterium, Eating, Female, Glucose, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Models, Biological, Tritium, Glucose Clamp Technique, Databases, Factual

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Minimal model estimation of glucose absorption and insulin sensitivity from oral test: validation with a tracer method

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