The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats
Abstract
Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes in later life. We have developed a model of uteroplacental insufficiency, a common cause of intrauterine growth retardation, in the rat. Early in life, the animals are insulin resistant and by 6 mo of age they develop diabetes. Glycogen content and insulin-stimulated 2-deoxyglucose uptake were significantly decreased in muscle from IUGR rats. IUGR muscle mitochondria exhibited significantly decreased rates of state 3 oxygen consumption with pyruvate, glutamate, α-ketoglutarate, and succinate. Decreased pyruvate oxidation in IUGR mitochondria was associated with decreased ATP production, decreased pyruvate dehydrogenase activity, and increased expression of pyruvate dehydrogenase kinase 4. Such a defect in IUGR mitochondria leads to a chronic reduction in the supply of ATP available from oxidative phosphorylation. Impaired ATP synthesis in muscle compromises energy-dependent GLUT4 recruitment to the cell surface, glucose transport, and glycogen synthesis, which contribute to insulin resistance and hyperglycemia of type 2 diabetes.
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“IUGR animals exhibit marked insulin resistance early in life (before the onset of hyperglycemia), characterized by blunted whole body glucose disposal in response to insulin (45).”
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Cited by
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910
Developmental origins of metabolic diseases
Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2021) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 466
Mechanisms involved in the developmental programming of adulthood disease
Warner, M. J., & Ozanne, S. E. (2010) · Biochemical Journal · doi:10.1042/bj20091861 · Cited by 316
Early-Life Origins of Type 2 Diabetes: Fetal Programming of the Beta-Cell Mass
Portha, B., Chavey, A., & Movassat, J. (2011) · Experimental Diabetes Research · doi:10.1155/2011/105076 · Cited by 127
da Silva Aragão, R., Guzmán-Quevedo, O., Pérez-García, G., Manhães-de-Castro, R., & Bolaños-Jiménez, F. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000865 · Cited by 35
Metadata
- Authors
- Selak, M. A., Storey, B. T., Peterside, I., & Simmons, R. A.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2003-07
- Volume
- 285
- Issue
- 1
- Pages
- E130-E137
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2153007475
- Cited by
- 162
- References
- 13
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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