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Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner
Open accessAbstract
Glucagon-like peptide-1 (GLP-1) may have direct favorable effects on cardiovascular system. The aim of this study was to investigate the effects of the GLP-1 analog exenatide on improving coronary endothelial function in patients with type 2 diabetes and to investigate the underlying mechanisms. The newly diagnosed type 2 diabetic subjects were enrolled and given either lifestyle intervention or lifestyle intervention plus exenatide treatment. After 12-wk treatment, coronary flow velocity reserve (CFVR), an important indicator of coronary endothelial function, was improved significantly, and serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were remarkably decreased in the exenatide treatment group compared with the baseline and the control group. Notably, CFVR was correlated inversely with hemoglobin A 1c (Hb A 1c ) and positively with high-density lipoprotein cholesterol (HDL-C). In human umbilical vein endothelial cells, exendin-4 (a form of exenatide) significantly increased NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner. The GLP-1 receptor (GLP-1R) antagonist exendin (9–39) or GLP-1R siRNA, adenylyl cyclase inhibitor SQ-22536, AMPK inhibitor compound C, and PI3K inhibitor LY-294002 abolished the effects of exendin-4. Furthermore, exendin-4 reversed homocysteine-induced endothelial dysfunction by decreasing sICAM-1 and reactive oxygen species (ROS) levels and upregulating NO production and eNOS phosphorylation. Likewise, exendin (9–39) diminished the protective effects of exendin-4 on the homocysteine-induced endothelial dysfunction. In conclusion, exenatide significantly improves coronary endothelial function in patients with newly diagnosed type 2 diabetes. The effect may be mediated through activation of AMPK/PI3K-Akt/eNOS pathway via a GLP-1R/cAMP-dependent mechanism.
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“Second, GLP-1RAs encourage initiating anti-inflammatory mechanisms such as the AMP-activated protein kinase (AMPK) pathway, which helps suppress inflammation.”
From Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications (2024) · cites this paper as [31]
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“In vitro/ex vivo studies conducted on endothelial cells showed that GLP-1RAs such as exenatide and liraglutide stimulate endothelial NO production and endothelial nitric oxide synthase (eNOS) activation, eliciting vasodilatation through activation of the GLP-1 receptor-dependent AMP-activated protein kinase (AMPK)/protein kinase B (Akt)/eNOS signaling pathway [48–50].”
From Protection against stroke with glucagon-like peptide-1 receptor agonists: a comprehensive review of potential mechanisms (2022) · cites this paper as [49]
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Citations
Cites
1 retracted
Wang, S., Xu, J. C., Song, P., Viollet, B., & Zou, M. (2009) · Diabetes · doi:10.2337/db09-0267 · Cited by 137
RetractedAtherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Standards of Medical Care in Diabetes—2012
(2012) · Diabetes Care · doi:10.2337/dc12-s011 · Cited by 2,240
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
Hink, U., Li, H., Mollnau, H., Oelze, M., Matheis, E., Hartmann, M., Skatchkov, M. P., Thaiss, F., Stahl, R. A. K., Warnholtz, A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.2.e14 · Cited by 1,191
Ban, K., Noyan-Ashraf, M. H., Hoefer, J., Bolz, S.-S., Drucker, D. J., & Husain, M. (2008) · Circulation · doi:10.1161/circulationaha.107.739938 · Cited by 1,057
Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus
Guzik, T. J., Mussa, S., Gastaldi, D., Sadowski, J., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2002) · Circulation · doi:10.1161/01.cir.0000012748.58444.08 · Cited by 979
Nyström, T., Gutniak, M. K., Zhang, Q., Zhang, F., Holst, J. J., Ahrén, B., & Sjöholm, Å. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00237.2004 · Cited by 680
Arakawa, M., Mita, T., Azuma, K., Ebato, C., Goto, H., Nomiyama, T., Fujitani, Y., Hirose, T., Kawamori, R., & Watada, H. (2010) · Diabetes · doi:10.2337/db09-1694 · Cited by 548
Heitzer, T., Krohn, K., Albers, S., & Meinertz, T. (2000) · Diabetologia · doi:10.1007/s001250051551 · Cited by 427
Hozumi, T., Yoshida, K., Akasaka, T., Asami, Y., Ogata, Y., Takagi, T., Kaji, S., Kawamoto, T., Ueda, Y., & Morioka, S. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00389-1 · Cited by 425
Research works printed but not linked: 1
- Yu J, 2013, J Geriatr Cardiol, 10, 159
Cited by
Sorted by citations
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Nauck, M. A., Quast, D. R., Wefers, J., & Meier, J. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101102 · Cited by 1,647
Nauck, M. A., Meier, J. J., Cavender, M. A., Abd El Aziz, M., & Drucker, D. J. (2017) · Circulation · doi:10.1161/circulationaha.117.028136 · Cited by 582
Rakipovski, G., Rolin, B., Nøhr, J., Klewe, I., Frederiksen, K. S., Augustin, R., Hecksher-Sørensen, J., Ingvorsen, C., Polex-Wolf, J., & Knudsen, L. B. (2018) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2018.09.004 · Cited by 509
Entezari, M., Hashemi, D., Taheriazam, A., Zabolian, A., Mohammadi, S., Fakhri, F., Hashemi, M., Hushmandi, K., Ashrafizadeh, M., Zarrabi, A., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112563 · Cited by 410
RetractedAnti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications
Alharbi, S. H. (2024) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188231222367 · Cited by 358
GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential
Ma, X., Liu, Z., Ilyas, I., Little, P. J., Kamato, D., Sahebka, A., Chen, Z., Luo, S., Zheng, X., Weng, J., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59965 · Cited by 299
Emerging Role of cAMP/AMPK Signaling
Aslam, M., & Ladilov, Y. (2022) · Cells · doi:10.3390/cells11020308 · Cited by 241
Dessauer, C. W., Watts, V. J., Ostrom, R. S., Conti, M., Dove, S., & Seifert, R. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013078 · Cited by 201
Sposito, A. C., Berwanger, O., de Carvalho, L. S. F., & Saraiva, J. F. K. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0800-2 · Cited by 171
Nauck, M. A., & Quast, D. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.645566 · Cited by 118
Role of PI3K in the Progression and Regression of Atherosclerosis
Zhao, Y., Qian, Y., Sun, Z., Shen, X., Cai, Y., Li, L., & Wang, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.632378 · Cited by 104
Salvatore, T., Galiero, R., Caturano, A., Vetrano, E., Loffredo, G., Rinaldi, L., Catalini, C., Gjeloshi, K., Albanese, G., Di Martino, A., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092274 · Cited by 98
Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction
Qin, Q., Delrio, S., Wan, J., Widmer, R. J., Cohen, P., Lerman, L. O., & Lerman, A. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.12.001 · Cited by 95
Candeias, E., Sebastião, I., Cardoso, S., Carvalho, C., Santos, M. S., Oliveira, C. R., Moreira, P. I., & Duarte, A. I. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0622-3 · Cited by 89
Liu, J., Yang, K., Yang, J., Xiao, W., Le, Y., Yu, F., Gu, L., Lang, S., Tian, Q., Jin, T., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.02.037 · Cited by 85
Self-citationYap, M. K. K., & Misuan, N. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13169 · Cited by 82
Coffee and Endothelial Function: A Coffee Paradox?
Higashi, Y. (2019) · Nutrients · doi:10.3390/nu11092104 · Cited by 75
GLP-1 agonist to treat obesity and prevent cardiovascular disease: what have we achieved so far
Pedrosa, M. R., Franco, D. R., Gieremek, H. W., Vidal, C. M., Bronzeri, F., de Cassia Rocha, A., de Carvalho Cara, L. G., Fogo, S. L., & Eliaschewitz, F. G. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01062-2 · Cited by 68
Ribeiro-Silva, J. C., Tavares, C. A. M., & Girardi, A. C. C. (2023) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2023.102355 · Cited by 71
Vergès, B., Aboyans, V., Angoulvant, D., Boutouyrie, P., Cariou, B., Hyafil, F., Mohammedi, K., & Amarenco, P. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01686-3 · Cited by 72
AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases
Lu, Q., Li, X., Liu, J., Sun, X., Rousselle, T., Ren, D., Tong, N., & Li, J. (2019) · Bioscience Reports · doi:10.1042/bsr20181995 · Cited by 69
Chen, J., Wang, D., Wang, F., Shi, S., Chen, Y., Yang, B., Tang, Y., & Huang, C. (2017) · Peptides · doi:10.1016/j.peptides.2017.02.008 · Cited by 64
Therapeutic application of GPR119 ligands in metabolic disorders
Yang, J. W., Kim, H. S., Choi, Y., Kim, Y., & Kang, K. W. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13062 · Cited by 63
Self-citationLiraglutide for Lower Limb Perfusion in People With Type 2 Diabetes and Peripheral Artery Disease
Caruso, P., Maiorino, M. I., Longo, M., Porcellini, C., Matrone, R., Selvaggio, L. D., Gicchino, M., Carbone, C., Scappaticcio, L., Bellastella, G., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.1545 · Cited by 65
Treatment of Obesity in Mitigating Metabolic Risk
Heffron, S. P., Parham, J. S., Pendse, J., & Alemán, J. O. (2020) · Circulation Research · doi:10.1161/circresaha.119.315897 · Cited by 62
Cheng, C. K., Luo, J., Lau, C. W., Cho, W. C. S., Ng, C., Ronald, C. W., Tian, X. Y., & Huang, Y. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00589-x · Cited by 58
Hullon, D., Subeh, G. K., Volkova, Y., Janiec, K., Trach, A., & Mnevets, R. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02607-w · Cited by 59
Jia, Y., Zheng, Z., Guan, M., Zhang, Q., Yang, L., Wang, L., & Xue, Y. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0084-3 · Cited by 55
Vascular (dys)function in the failing heart
Liberale, L., Duncker, D. J., Hausenloy, D. J., Kraler, S. C., Bøtker, H. E., Podesser, B. K., Heusch, G., & Kleinbongard, P. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01163-w · Cited by 58
Li, Y., Glotfelty, E. J., Karlsson, T. E., Fortuno, L. V., Harvey, B. K., & Greig, N. H. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15521 · Cited by 47
Qassab, M. A., Mneimneh, M., Jradi, A., Derbas, B., Dabboussi, D., Baini, J. K., Katrib, N., Chaarani, N., Attieh, P., Kanaan, A., et al. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47040285 · Cited by 61
AMPK pathway: an emerging target to control diabetes mellitus and its related complications
Kakoti, B. B., Alom, S., Deka, K., & Halder, R. (2024) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-024-01420-8 · Cited by 50
Yu, W., Chen, Y., Hwang, P., Chen, T., & Chou, T. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700136 · Cited by 45
Garczorz, W., Gallego-Colón, E., Kosowska, A., Kłych‐Ratuszny, A., Woźniak, M., Marcol, W., Niesner, K. J., & Francuz, T. (2017) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12317 · Cited by 43
Savarese, G., Butler, J., Lund, L. H., Bhatt, D. L., & Anker, S. D. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab271 · Cited by 45
Shao, S., Zhang, X., Xu, Q., Pan, R., & Chen, Y. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108270 · Cited by 42
Abdelmalek, M. F., Harrison, S. A., & Sanyal, A. J. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15524 · Cited by 45
Glucose-Dependent Insulinotropic Polypeptide Suppresses Peripheral Arterial Remodeling in Male Mice
Mori, Y., Kushima, H., Koshibu, M., Saito, T., Hiromura, M., Kohashi, K., Terasaki, M., Seino, Y., Yamada, Y., & Hirano, T. (2018) · Endocrinology · doi:10.1210/en.2018-00336 · Cited by 41
Ke, J., Liu, Y., Yang, J., Lu, R., Tian, Q., Hou, W., Wang, G., Wei, R., & Hong, T. (2017) · Scientific Reports · doi:10.1038/srep41085 · Cited by 38
Self-citationIncretin drugs as modulators of atherosclerosis
Gallego-Colon, E., Wojakowski, W., & Francuz, T. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.09.011 · Cited by 35
GLP-1 Receptor Agonists and Myocardial Perfusion: Bridging Mechanisms to Clinical Outcomes
Karakasis, P., Patoulias, D., Theofilis, P., Pamporis, K., Sagris, Μ., Vlachakis, P. K., Koufakis, T., Antoniadis, A. P., & Fragakis, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073050 · Cited by 38
Lyu, J., Imachi, H., Fukunaga, K., Sato, S., Kobayashi, T., Dong, T., Saheki, T., Matsumoto, M., Iwama, H., Zhang, H., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.12.015 · Cited by 36
Ngabea, M. A., & Dimeji, I. Y. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152822 · Cited by 35
Wu, Q., Li, D., Huang, C., Zhang, G., Wang, Z., Liu, J., Yu, H., Song, B., Zhang, N., Li, B., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113517 · Cited by 32
Bakbak, E., Terenzi, D. C., Trac, J. Z., Teoh, H., Quan, A., Glazer, S. A., Rotstein, O. D., Al-Omran, M. A., Verma, S., & Hess, D. A. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09669-7 · Cited by 32
Vascular and metabolic effects of SGLT2i and GLP-1 in heart failure patients
Correale, M., Lamacchia, O., Ciccarelli, M., Dattilo, G., Tricarico, L., & Brunetti, N. D. (2021) · Heart Failure Reviews · doi:10.1007/s10741-021-10157-y · Cited by 29
Cardiovascular effects of incretins: focus on glucagon-like peptide-1 receptor agonists
Madsbad, S., & Holst, J. J. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac112 · Cited by 37
Jarade, C., Zolotarova, T., Moiz, A., & Eisenberg, M. J. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102789 · Cited by 31
Le, Y., Wei, R., Yang, K., Lang, S., Gu, L., Liu, J., Hong, T., & Yang, J. (2019) · Peptides · doi:10.1016/j.peptides.2019.170212 · Cited by 28
Self-citationZhang, X., Cao, C., Zheng, F., Liu, C., & Tian, X. (2026) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-025-07670-9 · Cited by 27
“Vasodilation is achieved by activating endothelial nitric oxide synthase (eNOS) and increasing nitric oxide (NO) production via the cAMP/PKA, AMPK, and PI 3 K/Akt signaling pathways [17].”
Wang, T., Ding, J., Cheng, X., Yang, Q., & Hu, P. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1396656 · Cited by 29
Aung, M. M., Slade, K., Freeman, L. A. R., Kos, K., Whatmore, J. L., Shore, A. C., & Gooding, K. M. (2019) · Diabetologia · doi:10.1007/s00125-019-4918-x · Cited by 27
Chen, X., Zhang, X., Xiang, X., Fang, X., & Feng, S. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01497-4 · Cited by 26
Heo, K., Phan, L. P., Le, N. T. T., & Jin, Y. (2025) · Archives of Pharmacal Research · doi:10.1007/s12272-025-01542-4 · Cited by 29
Battistoni, A., Piras, L., Tartaglia, N., Carrano, F. M., Vitis, C. D., & Barbato, E. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1669685 · Cited by 31
Wang, Z., Wang, M., Hu, X.-F., Li, Y., Ma, D., Li, S.-L., Zhao, G., Xie, Y., Shu, Y., & Yang, J. (2018) · Transplantation · doi:10.1097/tp.0000000000002448 · Cited by 26
Self-citationHFpEF and MASLD: converging mechanisms and clinical implications
Capone, F., Häseli, S. P., Liu, L., Strocchi, S., Langenberg, C., Lusis, A. J., Pietzner, M., Muoio, D. M., Rider, O. J., Raman, B., et al. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01257-z · Cited by 35
Hassan, N. F., Ragab, D., Ibrahim, S. G., Elgalil, M. M. A., Abd-El-Hamid, A. H., Hamed, D. M., William, M. M., & Salem, M. A. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112308 · Cited by 24
Vinci, M. C., Gambini, E., Bassetti, B., Genovese, S., & Pompilio, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113864 · Cited by 24
Ke, J., Wei, R., Yu, F., Zhang, J., & Hong, T. (2016) · Peptides · doi:10.1016/j.peptides.2016.10.009 · Cited by 24
Self-citationXie, Z., Enkhjargal, B., Matei, N., Wu, L., Zhu, Q., Zhang, T., Tang, J., & Zhang, J. H. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.750726 · Cited by 24
Clinical Impact of Glucagon-Like Peptide-1 Receptor Analogs on the Complications of Obesity
Yazıcı, D., Eser, H. Y., Kiyici, S. K., Sancak, S., Sezer, H., Uygur, M., & Yumuk, V. (2022) · Obesity Facts · doi:10.1159/000526808 · Cited by 26
Ji, Q. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.03.013 · Cited by 21
Hu, Y., Liu, J., Wang, G., & Xu, Y. (2018) · Diabetes Therapy · doi:10.1007/s13300-018-0435-z · Cited by 21
Self-citationSuhrs, H. E., Raft, K. F., Bove, K. B., Madsbad, S., Holst, J. J., Zander, M., & Prescott, E. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.12.005 · Cited by 21
A primer on obesity-related cardiomyopathy
Samson, W. K., Yosten, G. L. C., & Remme, C. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00023.2021 · Cited by 23
Peng, Y., Lin, H., Tian, S., Liu, S., Li, J., Lv, X., Chen, S., Zhao, L., Pu, F., Chen, X., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.10.034 · Cited by 19
Kang, L., Li, X., Zhao, X., Liu, T., Jin, Y., & Duan, Y. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.143677 · Cited by 18
Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model
Zhu, Y., Li, Y., Ma, Y., Zhang, X., Du, X., Gao, J., Ding, N., Wang, L., Ni, C., Luo, M., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.026586 · Cited by 18
Ethyl Rosmarinate Protects High Glucose-Induced Injury in Human Endothelial Cells
Shen, Y., Wang, L., Zhang, B., Hu, Q.-M., Wang, P., He, B.-Q., Bao, G., Liang, J., & Wu, F. (2018) · Molecules · doi:10.3390/molecules23123372 · Cited by 17
Shao, J., Miao, C., Geng, Z., Gu, M.-H., Wu, Y., & Li, Q. (2019) · BioMed Research International · doi:10.1155/2019/5201014 · Cited by 17
Jin, L., Sun, Y., Li, Y., Zhang, H., Yu, W., Li, Y., Xin, Y., Alsareii, S. A., Wang, Q., & Zhang, D. (2021) · Peptides · doi:10.1016/j.peptides.2021.170597 · Cited by 17
Verouhis, D., Saleh, N., Settergren, M., Sörensson, P., Gourine, A. V., & Pernow, J. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.09.061 · Cited by 16
Ciuceis, C. D., Rosei, C. A., Rossini, C., Caletti, S., Coschignano, M. A., Ferrari‐Toninelli, G., Ragni, G., Cappelli, C., Cerudelli, B., Airó, P., et al. (2018) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-018-0279-7 · Cited by 16
GLP-1/GLP-1R axis: from metabolism (obesity and T2DM) to immunity
Kumar, V. (2025) · Open Biology · doi:10.1098/rsob.240303 · Cited by 17
Hardoňová, M., Šiarnik, P., Siváková, M., Sucha, B., Penesová, A., Rádiková, Ž., Havranová, A., Imrich, R., Vlček, M., Žitňanová, I., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311162 · Cited by 15
Glucagon-like Peptide-1 Receptor Agonists
Jeon, J. Y., & Kim, H. J. (2021) · Stroke revisited · doi:10.1007/978-981-16-5123-6_14 · Cited by 16
Pleiotropic effects of GLP‐1 receptor agonists on peripheral artery disease: Is there any hope?
Caruso, P., Maiorino, M. I., Bellastella, G., Esposito, K., & Giugliano, D. (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3627 · Cited by 13
Remm, F., Kränkel, N., Lener, D., Drucker, D. J., Sopper, S., & Brenner, C. (2018) · Stem Cells International · doi:10.1155/2018/5284963 · Cited by 14
Zhao, Q., Xu, H., Zhang, L., Liu, L., & Wang, L. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1620248 · Cited by 13
RetractedMolecular damage associated with ageing drives inflammation in cardiovascular disease
Herman, A. B., Candia, J., Wilson, D., Donegà, S., Picard, M. A., & Ferrucci, L. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01253-3 · Cited by 14
Ståhle, M. R., Hellberg, S., Virta, J., Liljenbäck, H., Metsälä, O., Li, X., Jauhiainen, M., Saukko, P. J., Ylä‐Herttuala, S., Nuutila, P., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00465.2020 · Cited by 12
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Metadata
- Authors
- Wei, R., Ma, S., Wang, C., Ke, J., Yang, J., Li, W., Liu, Y., Hou, W., Feng, X., Wang, G., & Hong, T.
- Affiliations
- Department of Endocrinology and Metabolism and
- Peking University Third Hospital (CN)
- Corresponding author
- Hong, Tianpei
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2016-06-01
- Volume
- 310
- Issue
- 11
- Pages
- E947-E957
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2339053935
- Cited by
- 137
- References
- 41
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 16 · 2023: 8 · 2022: 14 · 2021: 17 · 2020: 8 · 2019: 13 · 2018: 14 · 2017: 11 · 2016: 2
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- exenatide, GLP-1 receptor, exendin-4, coronary endothelial function, type 2 diabetes, endothelial nitric oxide synthase, coronary flow velocity reserve, soluble adhesion molecules, cAMP signaling, exendin-9-39, reactive oxygen species
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Exenatide, Adult, Cardiotonic Agents, Diabetic Angiopathies, Dose-Response Relationship, Drug, Echocardiography, Endothelium, Vascular, Female, Humans, Hypoglycemic Agents, Male, Middle Aged, Multienzyme Complexes, Peptides, Venoms, Signal Transduction, Oncogene Protein v-akt, Nitric Oxide Synthase Type III, AMP-Activated Protein Kinases
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