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Cited by 173Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors

You, Tongjian, Yang, Rongze, Lyles, Mary F., Gong, Dawei, Nicklas, Barbara J.·2005·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00419.2004
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Abstract

Adipose tissue is a major source of inflammatory and thrombotic cytokines. This study investigated the relationship of abdominal subcutaneous adipose tissue cytokine gene expression to body composition, fat distribution, and metabolic risk during obesity. We determined body composition, abdominal fat distribution, plasma lipids, and abdominal subcutaneous fat gene expression of leptin, TNF-α, IL-6, PAI-1, and adiponectin in 20 obese, middle-aged women (BMI, 32.7 ± 0.8 kg/m 2; age, 57 ± 1 yr). A subset of these women without diabetes ( n = 15) also underwent an OGTT. In all women, visceral fat volume was negatively related to leptin ( r = −0.46, P < 0.05) and tended to be negatively related to adiponectin ( r = −0.38, P = 0.09) gene expression. Among the nondiabetic women, fasting insulin ( r = 0.69, P < 0.01), 2-h insulin ( r = 0.56, P < 0.05), and HOMA index ( r = 0.59, P < 0.05) correlated positively with TNF-α gene expression; fasting insulin ( r = 0.54, P < 0.05) was positively related to, and 2-h insulin ( r = 0.49, P = 0.06) tended to be positively related to, IL-6 gene expression; and glucose area ( r = −0.56, P < 0.05) was negatively related to, and insulin area ( r = −0.49, P = 0.06) tended to be negatively related to, adiponectin gene expression. Also, adiponectin gene expression was significantly lower in women with vs. without the metabolic syndrome (adiponectin-β-actin ratio, 2.26 ± 0.46 vs. 3.31 ± 0.33, P < 0.05). We conclude that abdominal subcutaneous adipose tissue expression of inflammatory cytokines is a potential mechanism linking obesity with its metabolic comorbidities.

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Crossref · 10.1152/ajpendo.00419.2004

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Metadata

Authors
You, T., Yang, R., Lyles, M. F., Gong, D., & Nicklas, B. J.
Affiliations
Wake Forest University Health Sciences (US)
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2005-04
Volume
288
Issue
4
Pages
E741-E747
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.00419.2004
OpenAlex
W2120159188
Cited by
173
References
45
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 10
FWCI
10.82
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • Wake Forest University
  • Wake Forest School of Medicine
  • National Institute on Aging (R01-AG/DK20583, P30AG-21332, P30AG021332)
  • National Center for Research Resources (M01RR-07122, M01RR007122)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
subcutaneous abdominal fat, cytokine gene expression, obesity, metabolic syndrome, leptin, adiponectin, TNF-α, interleukin-6, plasminogen activator inhibitor-1, visceral fat, insulin resistance, HOMA index, glucose tolerance, middle-aged women, adipose tissue inflammation
MeSH terms
Abdomen, Adipose Tissue, Aged, Blood Glucose, Body Composition, Female, Gene Expression Regulation, Glucose Tolerance Test, Humans, Insulin, Cholesterol, HDL, Middle Aged, Obesity, Triglycerides, Tumor Necrosis Factor-alpha, Exercise, Absorptiometry, Photon, Interleukin-6, Cytokines, Plasminogen Activator Inhibitor 1, Leptin, Metabolic Syndrome, Intercellular Signaling Peptides and Proteins, Adiponectin

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