Cited by 173Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

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Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors

You, Tongjian, Yang, Rongze, Lyles, Mary F., Gong, Dawei, Nicklas, Barbara J.·2005·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00419.2004

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Abstract

Adipose tissue is a major source of inflammatory and thrombotic cytokines. This study investigated the relationship of abdominal subcutaneous adipose tissue cytokine gene expression to body composition, fat distribution, and metabolic risk during obesity. We determined body composition, abdominal fat distribution, plasma lipids, and abdominal subcutaneous fat gene expression of leptin, TNF-α, IL-6, PAI-1, and adiponectin in 20 obese, middle-aged women (BMI, 32.7 ± 0.8 kg/m 2; age, 57 ± 1 yr). A subset of these women without diabetes ( n = 15) also underwent an OGTT. In all women, visceral fat volume was negatively related to leptin ( r = −0.46, P < 0.05) and tended to be negatively related to adiponectin ( r = −0.38, P = 0.09) gene expression. Among the nondiabetic women, fasting insulin ( r = 0.69, P < 0.01), 2-h insulin ( r = 0.56, P < 0.05), and HOMA index ( r = 0.59, P < 0.05) correlated positively with TNF-α gene expression; fasting insulin ( r = 0.54, P < 0.05) was positively related to, and 2-h insulin ( r = 0.49, P = 0.06) tended to be positively related to, IL-6 gene expression; and glucose area ( r = −0.56, P < 0.05) was negatively related to, and insulin area ( r = −0.49, P = 0.06) tended to be negatively related to, adiponectin gene expression. Also, adiponectin gene expression was significantly lower in women with vs. without the metabolic syndrome (adiponectin-β-actin ratio, 2.26 ± 0.46 vs. 3.31 ± 0.33, P < 0.05). We conclude that abdominal subcutaneous adipose tissue expression of inflammatory cytokines is a potential mechanism linking obesity with its metabolic comorbidities.

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Effects of the Menopause Transition on Body Fatness and Body Fat Distribution
Tchernof, A., & Poehlman, É. T. (1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00344.x · Cited by 167
Retracted
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
The Metabolic Syndrome: Prevalence and Associated Risk Factor Findings in the US Population From the Third National Health and Nutrition Examination Survey, 1988-1994
Park, Y.-W., Zhu, S., Palaniappan, L., Heshka, S., Carnethon, M. R., & Heymsfield, S. B. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.4.427 · Cited by 2,074
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305

Show all 45 references

Research works printed but not linked: 1

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Buemann, B., Astrup, A. V., Pedersen, O. B., Black, E., Holst, J. J., Toubro, S., Echwald, S. M., Holst, J. J., Rasmussen, C., & Sørensen, T. I. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1062 · Cited by 43
Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial
Kopp, L., Schweinlin, A., Tingö, L., Hutchinson, A. N., Feit, V., Jähnichen, T., Lehnert, K., Vetter, W., Rings, A., Jensen, M. G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108567 · Cited by 46
Exercise-Induced Signals for Vascular Endothelial Adaptations: Implications for Cardiovascular Disease
Jenkins, N. T., Martin, J. S., Laughlin, M. H., & Padilla, J. (2012) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-012-0241-5 · Cited by 41
Adipokine signatures of subcutaneous and visceral abdominal fat in normal-weight and obese women with different metabolic profiles
Korać, A., Srdić, B., Stančić, A., Otašević, V., Korać, B., & Janković, A. (2021) · Archives of Medical Science · doi:10.5114/aoms/92118 · Cited by 48
Adiponectin gene expression and adipocyte NF-κB transcriptional activity in elderly overweight and obese women: inter-relationships with fat distribution, hs-CRP, leptin and insulin resistance
Zamboni, M. M., Francesco, V. D., Garbin, U., Pasini, A., Mazzali, G., Stranieri, C., Zoico, E., Fantin, F., Bosello, O., & Cominacini, L. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803563 · Cited by 41
Ramadan Fasting During the COVID-19 Pandemic; Observance of Health, Nutrition and Exercise Criteria for Improving the Immune System
Moghadam, M. T., Taati, B., Ardakani, S. M. P., & Suzuki, K. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.570235 · Cited by 41
Beneficial effects of hydro-alcoholic extract of Caralluma fimbriata against high-fat diet-induced insulin resistance and oxidative stress in Wistar male rats
Sudhakara, G., Mallaiah, P., Sreenivasulu, N., Rao, B. S. B., Rajendran, R., & Saralakumari, D. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0304-1 · Cited by 39
Polycystic ovary syndrome associated with increased adiposity interferes with serum levels of TNF-alpha and IL-6 differently from leptin and adiponectin
Cardoso, N. S., Ribeiro, V. B., Dutra, S. G. V., Ferriani, R. A., Gastaldi, A. C., de Araújo, J. E., & de Souza, H. C. D. (2020) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000197 · Cited by 39
Tracing the Anti‐Inflammatory Mechanism/Triggers of d ‐Allulose: A Profile Study of Microbiome Composition and mRNA Expression in Diet‐Induced Obese Mice
Han, Y., Yoon, J. H., & Choi, M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900982 · Cited by 37
The Effect of Enteric-Derived Lipopolysaccharides on Obesity
Wang, K., Lai, W., Min, T., Wei, J., Bai, Y., Cao, H., Guo, J., & Su, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084305 · Cited by 38
Not All Fat Is Equal
Modesitt, S. C., Hsu, J. Y., Chowbina, S., Lawrence, R., & Hoehn, K. L. (2012) · International Journal of Gynecological Cancer · doi:10.1097/igc.0b013e3182510496 · Cited by 35
Pharmacogenomics and cardiovascular drugs: Need for integrated biological system with phenotypes and proteomic markers
Siest, G., Marteau, J., Maumus, S., Berrahmoune, H., Jeannesson, É., Samara, A., Batt, A., & Visvikis‐Siest, S. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.011 · Cited by 35
Reduced circulating adiponectin levels are associated with the metabolic syndrome independently of obesity, lipid indices and serum insulin levels: a cross-sectional study
Ntzouvani, A., Fragopoulou, E., Panagiotakos, D. B., Pitsavos, C. E., & Antonopoulou, S. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0311-7 · Cited by 34
Glycaemic variability and inflammation in subjects with metabolic syndrome
Buscemi, S., Verga, S., Cottone, S., Azzolina, V., Buscemi, B., Gioia, D., & Cerasola, G. (2008) · Acta Diabetologica · doi:10.1007/s00592-008-0061-8 · Cited by 34
Over expression of resistin in adipose tissue of the obese induces insulin resistance
Sadashiv (2012) · World Journal of Diabetes · doi:10.4239/wjd.v3.i7.135 · Cited by 34
Obesity-associated digestive cancers: A review of mechanisms and interventions
Zheng, J., Zhao, M., Li, J., Lou, G., Yuan, Y., Bu, S., & Xi, Y. (2017) · Tumor Biology · doi:10.1177/1010428317695020 · Cited by 33
Morbidly obese women with and without endometrial cancer: Are there differences in measured physical fitness, body composition, or hormones?
Modesitt, S. C., Geffel, D. L., Via, J., & WELTMAN, A. L. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.11.013 · Cited by 35
Glucose metabolism affects coagulation factors: The NEO study
van der Toorn, F. A., de Mutsert, R., Lijfering, W. M., Rosendaal, F. R., & Vlieg, A. V. H. (2019) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14573 · Cited by 32
Novel porcine housekeeping genes for real-time RT-PCR experiments normalization in adipose tissue: Assessment of leptin mRNA quantity in different pig breeds
Piórkowska, K., Oczkowicz, M., Różycki, M., Ropka‐Molik, K., & Piestrzyńska-Kajtoch, A. (2010) · Meat Science · doi:10.1016/j.meatsci.2010.10.008 · Cited by 31
Effect of resistance exercise training on expression of Hsp70 and inflammatory cytokines in skeletal muscle and adipose tissue of STZ-induced diabetic rats
Shamsi, M. M., Mahdavi, M., Quinn, L. S., Gharakhanlou, R., & Isanegad, A. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0703-7 · Cited by 30
Changes of Dipeptidyl Peptidase IV (DPP-IV) in Obese Children with Weight Loss: Relationships to Peptide YY, Pancreatic Peptide, and Insulin Sensitivity
Reinehr, T., Roth, C. L., Enriori, P. J., & Masur, K. (2010) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2010.23.1-2.101 · Cited by 29
Metabolic Syndrome and Prediabetes
Babu, A. R., & Fogelfeld, L. A. (2006) · Disease-a-Month · doi:10.1016/j.disamonth.2006.03.001 · Cited by 27
Can early treatment with biologicals modify the natural history of comorbidities?
Vena, G. A., Vestita, M. G., & Cassano, N. (2010) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2010.01313.x · Cited by 28
Anti-obesity effects of enzymatically-digested alginate oligomer in mice model fed a high-fat-diet
Nakazono, S., Cho, K., Isaka, S., Abu, R., Yokose, T., Murata, M., Ueno, M., Tachibana, K., Hirasaka, K., Kim, D., et al. (2016) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2016.02.001 · Cited by 27
Dynapenic abdominal obesity is associated with mild cognitive impairment in patients with cardiometabolic disease: a cross-sectional study
Oba, K., Tamura, Y., Ishikawa, J., Suzuki, H., Fujiwara, Y., Tachibana, A., Kodera, R., Toyoshima, K., Chiba, Y., & Araki, A. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-02948-1 · Cited by 27
Approach to the diagnosis and management of lipoprotein disorders
Al-Waili, K., Al‐Rasadi, K., Awan, Z. A., & Genest, J. J. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328329135a · Cited by 26
Frequency of the metabolic syndrome in type 2 diabetic subjects attending the diabetes clinic of a tertiary care hospital.
Imam, S. K., Shahid, S. K., Hassan, A., & Alvi, Z. (2007) · PubMed · Cited by 24
Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?
Amit, P., Kuiper, J. H., James, S., & Snow, M. (2021) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2021.05.014 · Cited by 24
Adiponectin and leptin in human severe insulin resistance – Diagnostic utility and biological insights
Groeneveld, M. P., Huang‐Doran, I., & Semple, R. K. (2012) · Biochimie · doi:10.1016/j.biochi.2012.01.021 · Cited by 24
Distribuição centrípeta da gordura corporal, sobrepeso e aptidão cardiorrespiratória: associação com sensibilidade insulínica e alterações metabólicas
da Silva, J. L. T., Barbosa, D. S., de Oliveira, J. A., & Guedes, D. P. (2006) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302006000600009 · Cited by 22

Authors: You, T., Yang, R., Lyles, M. F., Gong, D., & Nicklas, B. J.
Affiliations: Wake Forest University Health Sciences (US)
ORCID: You, Tongjian
Lyles, Mary F.
Nicklas, Barbara J.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2005-04
Volume: 288
Issue: 4
Pages: E741-E747
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00419.2004
OpenAlex: W2120159188
Cited by: 173
References: 45
Citations by year: 2026: 3 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 10
FWCI: 10.82
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Wake Forest University
Wake Forest School of Medicine
National Institute on Aging (R01-AG/DK20583, P30AG-21332, P30AG021332)
National Center for Research Resources (M01RR-07122, M01RR007122)
NIH Clinical Center
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: subcutaneous abdominal fat, cytokine gene expression, obesity, metabolic syndrome, leptin, adiponectin, TNF-α, interleukin-6, plasminogen activator inhibitor-1, visceral fat, insulin resistance, HOMA index, glucose tolerance, middle-aged women, adipose tissue inflammation
MeSH terms: Abdomen, Adipose Tissue, Aged, Blood Glucose, Body Composition, Female, Gene Expression Regulation, Glucose Tolerance Test, Humans, Insulin, Cholesterol, HDL, Middle Aged, Obesity, Triglycerides, Tumor Necrosis Factor-alpha, Exercise, Absorptiometry, Photon, Interleukin-6, Cytokines, Plasminogen Activator Inhibitor 1, Leptin, Metabolic Syndrome, Intercellular Signaling Peptides and Proteins, Adiponectin

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Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors

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