The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus
Abstract
Resistance to the action of insulin can result from a variety of causes, including the formation of abnormal insulin or proinsulin molecules, the presence of circulating antagonists to insulin or the insulin receptor, or defects in insulin action at the target tissue level. Defects of the latter type are characteristic of obesity and of noninsulin-dependent diabetes mellitus. Analysis of the nature of the insulin resistance in those disorders has been investigated in intact subjects with the use of the euglycemic glucose clamp technique, and both insulin receptors and insulin-mediated glucose metabolism have been studied in adipocytes and monocytes from affected individuals. In both conditions, the cause of insulin resistance is heterogeneous. In some, insulin resistance appears to be due to a defect in the insulin receptor, whereas others have a defect both in the receptor and at the postreceptor level. In both groups, more severe insulin resistance is due to the postreceptor lesion and is correctable with appropriate therapy.
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Citations
Cites
1 retracted
Insulin Sensitivity and Insulin Binding to Monocytes in Maturity-Onset Diabetes
Defronzo, R., Deibert, D., Hendler, R., Felig, P., & Soman, V. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109394 · Cited by 188
RetractedRandle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
A model of the kinetics of insulin in man
Sherwin, R. S., Kramer, K. J., Tobin, J. D., Insel, P. A., Liljenquist, J. E., Berman, M., & Andres, R. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107697 · Cited by 460
Insulin Control of Glucose Metabolism in Man
Insel, P. A., Liljenquist, J. E., Tobin, J. D., Sherwin, R. S., Watkins, P., Andres, R., & Berman, M. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108006 · Cited by 244
Ginsberg, H., Kimmerling, G., Olefsky, J. M., & Reaven, G. M. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107951 · Cited by 225
Self-citationInsulin Binding in Diabetes: Relationships with Plasma Insulin Levels and Insulin Sensitivity
Olefsky, J. M., & Reaven, G. M. (1977) · Diabetes · doi:10.2337/diab.26.7.680 · Cited by 202
Self-citation
Cited by
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s5 · Cited by 2,689
The Metabolic Syndrome: Time for a Critical Appraisal
Kahn, R., Buse, J., Ferrannini, E., & Stern, M. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2289 · Cited by 2,378
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465
Franz, M. J., Bantle, J. P., Beebe, C. A., Brunzell, J. D., Chiasson, J.-L., Garg, A., Holzmeister, L. A., Hoogwerf, B., Mayer-Davis, E., Mooradian, A. D., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.1.148 · Cited by 1,165
Metadata
- Authors
- Olefsky, J. M., Kolterman, O. G., & Scarlett, J. A.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1982-07-01
- Volume
- 243
- Issue
- 1
- Pages
- E15-E30
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2195824206
- Cited by
- 277
- References
- 6
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. https://app.cochat.ai/papers/10.1152/ajpendo.1982.243.1.e15
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- Olefsky, J. M., Kolterman, O. G., & Scarlett, J. A. (1982). Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1982.243.1.e15
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
