The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Measurement of total and organ-specific norepinephrine kinetics in humans
Abstract
A variety of biochemical tests, most notably measurement of the plasma concentration of norepinephrine, have been used to quantify overall sympathetic nervous system activity in humans. Plasma norepinephrine values provide a fallible index of sympathetic activity in that they are dependent in part on the rate of removal of norepinephrine from plasma. Measurement of the rate of release of norepinephrine to plasma is a better guide to overall sympathetic nervous tone because it avoids this confounding influence of norepinephrine plasma clearance. The overall norepinephrine spillover measurement, however, suffers from one major limitation: the sources of the released norepinephrine are not identified. Recently developed radiotracer techniques allow the estimation of regional sympathetic nervous activity from measurements of the organ-specific norepinephrine spillover rate. We find that the lungs are the main source of norepinephrine release to plasma, with mean pulmonary norepinephrine spillover of 159 ng/min constituting 40% of total norepinephrine release. Pulmonary norepinephrine release exceeded the combined norepinephrine spillover from the heart (3%), kidneys (17%), and hepatomesenteric circulation (8%).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The release and fate of vaso‐active hormones in the circulation
VANE, J. R. (1969) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1969.tb07982.x · Cited by 644
Circulating catecholamine levels in human and experimental hypertension.
de Champlain, J., Farley, L., Cousineau, D., & van Ameringen, M. R. (1976) · Circulation Research · doi:10.1161/01.res.38.2.109 · Cited by 355
The Peripheral Kinetics of Norepinephrine in Depressive Illness
Esler, M. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290030035006 · Cited by 195
Self-citationCOULOMBE, P., DUSSAULT, J. H., & WALKER, P. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-44-6-1185 · Cited by 170
Esler, M., Jackman, G., Bobik, A., Leonard, P., Kelleher, D., Skews, H., Jennings, G., & Korner, P. (1981) · Hypertension · doi:10.1161/01.hyp.3.2.149 · Cited by 165
Self-citationYamaguchi, N., de Champlain, J., & Nadeau, R. A. (1977) · Circulation Research · doi:10.1161/01.res.41.1.108 · Cited by 156
von Euler, U. S. (1948) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1948.tb00526.x · Cited by 147
Zegler, M. G., Lake, C. R., Wood, J. H., Brooks, B. R., & Ebert, M. H. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10444.x · Cited by 139
Comparison of Sympathetic Nerve Activity in Normotensive and Hypertensive Subjects
Wallin, B. G., Delius, W., & Hagbarth, K. E. (1973) · Circulation Research · doi:10.1161/01.res.33.1.9 · Cited by 137
Brown, M. J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)90058-1 · Cited by 116
Cited by
Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease
Malpas, S. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00007.2009 · Cited by 699
Esler, M., Jennings, G., Korner, P., Willett, I., Dudley, F., Hasking, G., Anderson, W., & Lambert, G. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.3 · Cited by 642
Self-citationCardiac Sympathetic Nerve Function in Congestive Heart Failure
Eisenhofer, G., Friberg, P., Rundqvist, B., Quyyumi, A. A., Lambert, G., Kaye, D. M., Kopin, I. J., Goldstein, D. S., & Esler, M. D. (1996) · Circulation · doi:10.1161/01.cir.93.9.1667 · Cited by 453
Self-citationRegional Sympathetic Nervous Activity and Oxygen Consumption in Obese Normotensive Human Subjects
Vaz, M., Jennings, G., Turner, A., Cox, H., Lambert, G., & Esler, M. (1997) · Circulation · doi:10.1161/01.cir.96.10.3423 · Cited by 404
Self-citationKaye, D. M., Lambert, G. W., Lefkovits, J., Morris, M., Jennings, G., & Esler, M. D. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90738-2 · Cited by 286
Self-citation
Metadata
- Authors
- Esler, M., Jennings, G., Korner, P., Blombery, P., Sacharias, N., & Leonard, P.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1984-07-01
- Volume
- 247
- Issue
- 1
- Pages
- E21-E28
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1764638724
- Cited by
- 270
- References
- 24
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Measurement of total and organ-specific norepinephrine kinetics in humans. https://app.cochat.ai/papers/10.1152/ajpendo.1984.247.1.e21
- The paper
- Esler, M., Jennings, G., Korner, P., Blombery, P., Sacharias, N., & Leonard, P. (1984). Measurement of total and organ-specific norepinephrine kinetics in humans. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1984.247.1.e21
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
