Cited by 194Hypothalamic control of reproductive hormonesHormonal and reproductive studiesSperm and Testicular Function

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone

Spratt, D. I., O'Dea, L. S., Schoenfeld, D., Butler, J., Rao, P. N., Crowley, W. F.·1988·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.1988.254.5.e658

Open this paper in CoChat — free account

Abstract

Previous studies of episodic hormone secretion of the hypothalamic-pituitary-gonadal axis in normal men have produced conflicting results due to examinations of small cohorts of subjects or to limited sampling techniques. We evaluated gonadotropin and testosterone (T) secretory patterns in 20 normal men by sampling blood at 10-min intervals for luteinizing hormone (LH) and follicle-stimulating hormone (FSH). T concentrations were also analyzed at 20-min intervals in 10 subjects. A previously unappreciated spectrum of gonadotropin and T secretory patterns was observed in normal men. Both mean LH concentrations and mean LH pulse amplitudes varied fourfold between individuals. LH interpulse intervals varied from 30 to 480 min (mean 119 +/- 32). Results also suggested a relative refractory period at the level of the hypothalamus or pituitary. In three subjects, a striking nighttime accentuation of LH pulsations was noted. Through use of Fourier analysis, a diurnal variation in LH was observed in the population (P less than 0.02). Mean FSH levels showed marked variation between individual subjects, with discrete pulses rarely observed. No diurnal variation in FSH secretion was noted. Serum T concentrations determined at 6-h intervals ranged from 105 to 1,316 ng/dl between subjects. When T was measured at 20-min intervals, marked intermittent declines in the T concentrations to levels well below the normal range were observed in 3 of 10 subjects. T secretion was found to lag behind LH secretion by approximately 40 min (P less than 0.02).

Integrity signals

Registry

Crossref · 10.1152/ajpendo.1988.254.5.e658

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms
Santen, R. J., & Bardin, C. W. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107454 · Cited by 706
Neuroendocrine regulation of the corpus luteum in the human. Evidence for pulsatile progesterone secretion.
Filicori, M., Butler, J. P., & Crowley, W. F. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111370 · Cited by 547
Self-citation
Human puberty. Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep
Boyar, R. M., Rosenfeld, R. S., Kapen, S., Finkelstein, J. W., Roffwarg, H. P., Weitzman, E. D., & Hellman, L. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107798 · Cited by 317
Operating Characteristics of the Male Hypothalamo-Pituitary-Gonadal Axis: Pulsatile Release of Testosterone and Follicle-Stimulating Hormone and Their Temporal Coupling with Luteinizing Hormone*
Veldhuis, J. D., King, J. C., Urban, R. J., Rogol, A. D., Evans, W. S., Kolp, L. A., & JOHNSON, M. L. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-5-929 · Cited by 205
AGE- AND MENTAL HEALTH-RELATED CIRCADIAN RHYTHMS OF PLASMA LEVELS OF MELATONIN, PROLACTIN, LUTEINIZING HORMONE AND FOLLICLE-STIMULATING HORMONE IN MAN
Touitou, Y., Fèvre, M., Lagoguey, M., Carayon, A., Bogdan, A., Reinberg, A., Beck, H., Cesselin, F., & Touitou, C. (1981) · Journal of Endocrinology · doi:10.1677/joe.0.0910467 · Cited by 175
Twenty-Four Hour Pattern of Luteinizing Hormone Secretion in Normal Men with Sleep Stage Recording
BOYAR, R. M., Perlow, M. J., HELLMAN, L., Kapen, S., & Weitzman, E. D. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-1-73 · Cited by 145
Diurnal Cycles in Plasma FSH, Testosterone and Cortisol in Men1
Faiman, C., & Winter, J. S. D. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-2-186 · Cited by 130
Effects of Increasing the Frequency of Low Doses of Gonadotropin-Releasing Hormone (GnRH) on Gonadotropin Secretion in GnRH-Deficient Men*
Spratt, D. I., Finkelstein, J. S., Butler, J. P., Badger, T. M., & Crowley, W. F. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-6-1179 · Cited by 129
Self-citation
Integrated Concentration and Circadian Variation of Plasma Testosterone in Normal Men
de Lacerda, L., Kowarski, A. A., Johanson, A. J., Athanasiou, R., & Migeon, C. J. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-3-366 · Cited by 122
Radioimmunoassay of Human Follicle Stimulating and Luteinizing Hormones in Plasma1
Saxena, B. B., Demura, H., GANDY, H. M., & Peterson, R. E. (1968) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-28-4-519 · Cited by 119

Show all 31 references

Research works printed but not linked: 9

BAHN A. K, 1972, New York: Grune & Stratton, 182
CROWLEY W. F., 1985, Harm. Res., 41, 473
DE LA TORRE B., B., 1981, J. Androl., 4, 532
ELLIS G. B., 1982, J. Clin. Endocrinol. Metub., 110
FILICORI M., 1983, L. Norman. New York: Academic, 294
MARTINI L., M., 1968, Rec. Prog. Harm. Res., 24, 439
MATSUMOTO A., Metub., 58, 609
NAFTOLIN F., S., 1972, Nature Lord., 23, 92
NANKIN H. R., J. Clin. Endocrinol. Metub., 33, 197l

Sorted by citations

Items 101–192 of 192

Testosterone Synthesis, Transport, and Metabolism
Winters, S. J., & Clark, B. J. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-388-0_1 · Cited by 22
Interictal and Postictal Circadian and Ultradian Luteinizing Hormone Secretion in Men with Temporal Lobe Epilepsy
Quigg, M., Kiely, J. M., Johnson, M. L., Straume, M., Bertram, E. H., & Evans, W. S. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00617.x · Cited by 22
Use of Hormone Testing for the Diagnosis and Evaluation of Male Hypogonadism and Monitoring of Testosterone Therapy: Application of Hormone Testing Guideline Recommendations in Clinical Practice
Muram, D., Zhang, X., Cui, Z. L., & Matsumoto, A. M. (2015) · The Journal of Sexual Medicine · doi:10.1111/jsm.12968 · Cited by 21
Insight Into the Ontogeny of GnRH Neurons From Patients Born Without a Nose
Delaney, A., Volochayev, R., Meader, B. N., Lee, J. C. L., Almpani, K., Noukelak, G. Y., Henkind, J., Chalmers, L. J., Law, J. R., Williamson, K. A., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa065 · Cited by 19
Self-citation
Luteinizing hormone following light exposure in healthy young men
Yoon, I., Kripke, D. F., Elliott, J. A., & Youngstedt, S. D. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00122-8 · Cited by 19
The influence of maternal androgen excess on the male reproductive axis
Holland, S., Prescott, M., Pankhurst, M. W., & Campbell, R. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-55436-9 · Cited by 16
Rerouting of a Follicle-Stimulating Hormone Analog to the Regulated Secretory Pathway
Pearl, C. A., Jablonka‐Shariff, A., & Boime, I. (2009) · Endocrinology · doi:10.1210/en.2009-0939 · Cited by 17
Mechanisms of Disease: late-onset hypogonadism
Mahmoud, A., & Comhaire, F. H. (2006) · Nature Clinical Practice Urology · doi:10.1038/ncpuro0560 · Cited by 16
Short‐term fasting in normal women: absence of effects on gonadotrophin secretion and the menstrual cycle
Soules, M. R., Meriggiola, M. C., Steiner, R. A., Clifton, D. K., Toivola, B., & Bremner, W. J. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02505.x · Cited by 16
Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy
Genazzani, A. D., Forti, G., Maggi, M., Milloni, M., Cianfanelli, F., Guardabasso, V., Toscano, V., Serio, M., & Rodbard, D. (1990) · Journal of Endocrinological Investigation · doi:10.1007/bf03349621 · Cited by 19
Hormones and Metabolism during Sleep
Cauter, E. V., & Spiegel, K. (1997) · KARGER eBooks · doi:10.1159/000061553 · Cited by 15
Diagnosis of hypogonadism in ageing men
Kaufman, J. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09763-4 · Cited by 18
Absence of Apparent Circadian Rhythms of Gonadotropins and Free α-Subunit in Postmenopausal Women: Evidence for Distinct Regulation Relative to Other Hormonal Rhythms
Lavoie, H. B., Marsh, E. E., & Hall, J. E. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730405283244 · Cited by 14
Optimizing Diagnostic Accuracy and Treatment Decisions in Men With Testosterone Deficiency
Bhasin, S., & Ozimek, N. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.08.002 · Cited by 15
Management of Male Hypogonadotrophic Hypogonadism
Howles, C. M., Tanaka, T., & Matsuda, T. (2007) · Endocrine Journal · doi:10.1507/endocrj.02-kr-98 · Cited by 14
Is it andropause?
Tan, R. S., & Pu, S. (2004) · Postgraduate Medicine · doi:10.3810/pgm.2004.01.1419 · Cited by 13
Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
Copinschi, G., Turek, F. W., & Cauter, E. V. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00011-3 · Cited by 14
Current controversies in testosterone testing: aging and obesity
Elin, R. J., & Winters, S. J. (2004) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2004.01.010 · Cited by 13
Hormones and Sleep
Cauter, E. V. (1995) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57836-6_10 · Cited by 13
Decreasing Insulin Sensitivity in Women Induces Alterations in LH Pulsatility
Leckwyck, M. V., Kong, W., Burton, K. J., Amati, F., Vionnet, N., & Pralong, F. P. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1727 · Cited by 12
Fertility Considerations in Hypogonadal Men
Papanikolaou, N., Luo, R., & Jayasena, C. N. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.009 · Cited by 11
EFFECTS OF GLYCOSIDES BASED FENUGREEK SEED EXTRACT ON SERUM TESTOSTERONE LEVELS OF HEALTHY SEDENTARY MALE SUBJECTS: A EXPLORATORY DOUBLE BLIND, PLACEBO CONTROLLED, CROSSOVER STUDY
Thakurdesai, P. A., Mokashi, M., Mokashi, R. S., & Mohan, V. (2014) · Asian Journal of Pharmaceutical and Clinical Research · Cited by 11
[Physiology of androgens in adult men].
Tostain, J.-B., Rossi, D., & Martin, P. (2004) · PubMed · Cited by 12
Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids
Yao, Y., & Silver, R. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.877256 · Cited by 11
Daily Rhythmic and Non-Rhythmic Variations of Follitropin, Lutropin, Testosterone, and Sex-Hormone-Binding Globulin in Men
Valero-Politi, J., & Fuentes‐Arderiu, X. (1996) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1996.34.6.455 · Cited by 11
Managing endocrine dysfunction following blast injury to the male external genitalia
Woods, D. R., Phillip, R., & Quinton, R. (2013) · Journal of the Royal Army Medical Corps · doi:10.1136/jramc-2013-000022 · Cited by 11
Laboratory Assessment of Testicular Function
Winters, S. J. (2016) · Cited by 11
Neuroendocrine mechanisms of reproduction
Garg, D., & Berga, S. L. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64239-4.00001-1 · Cited by 13
Circadian Rhythms in Neuroendocrine Systems
Arble, D. M., Copinschi, G., Vitaterna, M. H., Cauter, E. V., & Turek, F. W. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10012-5 · Cited by 10
The circadian rhythm of atrial natriuretic peptide, vasoactive intestinal peptide, beta-endorphin and cortisol in healthy young and elderly subjects
Cugini, P., Lucia, P., Palma, L. D., Re, M., Canova, R., Gasbarrone, L., & Cianetti, A. (1992) · Clinical Autonomic Research · doi:10.1007/bf01819666 · Cited by 10
Testosterone Assays
King, B., Natale, C., & Hellstrom, W. J. G. (2022) · Urologic Clinics of North America · doi:10.1016/j.ucl.2022.07.009 · Cited by 9
The Gonadal Axis: A Life Perspective
Huhtaniemi, I. T., Howard, S. R., Dunkel, L., & Anderson, R. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00066-3 · Cited by 9
Role of Seminiferous Tubular Development in Determining the FSH versus LH Responsiveness to GnRH in Early Sexual Maturation
Pitteloud, N., Thambundit, A., Dwyer, A. A., Falardeau, J. L., Plummer, L., Caronia, L. M., Hayes, F. J., Lee, H., Boepple, P. A., & Crowley, W. F. (2009) · Neuroendocrinology · doi:10.1159/000245383 · Cited by 9
Self-citation
Endocrine Ultradian Rhythms During Sleep and Wakefulness
BRANDENBERGER, G. (1992) · Springer eBooks · doi:10.1007/978-1-4471-1969-2_7 · Cited by 9
In the Adult Male Rhesus Monkey (Macaca mulatta), Unilateral Orchidectomy in the Face of Unchanging Gonadotropin Stimulation Results in Partial Compensation of Testosterone Secretion by the Remaining Testis
Simorangkir, D. R., Ramaswamy, S., Marshall, G. R., & Plant, T. M. (2004) · Endocrinology · doi:10.1210/en.2004-0824 · Cited by 8
Defective regulation of glycoprotein free alpha-subunit in males with isolated gonadotropin-releasing hormone deficiency--a clinical research center study
Pralong, F. P., PAVLOU, S. N., Waldstreicher, J., Crowley, W. F., & Boepple, P. A. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530620 · Cited by 8
Self-citation
The lack of effect of insulin on luteinizing hormone pulsatility in healthy male volunteers provides evidence of a sexual dimorphism in the metabolic regulation of reproductive hormones
Pesant, M.-H., Dwyer, A. A., Marques-Vidal, P. M., Schneiter, P., Giusti, V., Tappy, L., & Pralong, F. P. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.030189 · Cited by 7
Strength-training and biological rhythm of male sex hormone among judoists
Shariat, A., Kargarfard, M., Tamrin, S. B. M., Danaee, M., & Karimi, H. (2014) · Biological Rhythm Research · doi:10.1080/09291016.2014.884304 · Cited by 7
Clinical problems in reproductive neuroendocrinology of men
Vermeulen, A. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90085-x · Cited by 7
A dileucine determinant in the carboxyl terminal sequence of the LHβ subunit is implicated in the regulated secretion of lutropin from transfected GH3 cells
Jablonka‐Shariff, A., & Boime, I. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.03.013 · Cited by 6
Interplay between Dose and Frequency of GnRH Administration in Determining Pituitary Gonadotropin Responsiveness
HUGHES, V. A., Boepple, P. A., Crowley, W. F., & Seminara, S. B. (2007) · Neuroendocrinology · doi:10.1159/000112421 · Cited by 6
Self-citation
Pulsatile gonadotropin releasing hormone therapy for spermatogenesis in congenital hypogonadotropic hypogonadism patients who had poor response to combined gonadotropin therapy
Huang, Z., Wang, X., Yu, B., Ma, W., Zhang, P., Wu, X., Nie, M., & Mao, J. (2024) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-4292-2023-0101 · Cited by 5
Aging‐related reproductive decline in the male spider monkey (Ateles geoffroyi)
Hernández-López, L. E., Cerda‐Molina, A. L., Díaz-Díaz, G., Chavira, R., & Mondragón‐Ceballos, R. (2012) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.2011.00528.x · Cited by 4
Gonadotropin Deficiency
Welt, C. K., & Hall, J. E. (1997) · Humana Press eBooks · doi:10.1007/978-1-4612-3954-3_11 · Cited by 5
Replicability of leptin associations with testosterone, estradiol, follicle‐stimulating hormone, and luteinizing hormone in healthy Ache men of Paraguay : A multiple daily assessment
Harries, V., & Bribiescas, R. G. (2021) · American Journal of Human Biology · doi:10.1002/ajhb.23638 · Cited by 4
New methods to investigate the GnRH pulse generator
Ivanova, D., & O’Byrne, K. T. (2023) · Journal of Molecular Endocrinology · doi:10.1530/jme-23-0079 · Cited by 5
Sulfation of LH does not affect intracellular trafficking
Pearl, C. A., & Boime, I. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.03.004 · Cited by 4
Exploración de la función testicular
Bassas, L. (2009) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(09)70190-1 · Cited by 3
Congenital Hypogonadotropic Hypogonadism
Crowley, W. F., & Pitteloud, N. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-727-7_5 · Cited by 3
Self-citation
Androgens in male senescence
Kaufman, J., T'Sjoen, G. G., & Vermeulen, A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139003353.017 · Cited by 3
[Age-related androgen deficiency: diagnostic work-up].
Rossi, D., & Tostain, J.-B. (2004) · PubMed · Cited by 3
Nutrition and Reproduction
Santoro, N. F., Polotsky, A. J., Rieder, J., & Kondapalli, L. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00018-4 · Cited by 3
Life History Tradeoffs Between Testosterone and Immune Function Among Shuar Forager-Horticulturalists of Amazonian Ecuador
Gildner, T. E. (2018) · Scholars' Bank (University of Oregon) · Cited by 2
Salivary Testosterone, Age, and Adiposity Associations Among Shuar Males in Amazonian Ecuador Challenge Assumptions of “Normal” Testosterone Patterns
Gildner, T. E., Liebert, M. A., Schrock, J. M., Urlacher, S. S., Amir, D., Harrington, C. J., Madimenos, F. C., Cepon‐Robins, T. J., Bribiescas, R. G., Sugiyama, L. S., et al. (2025) · American Journal of Human Biology · doi:10.1002/ajhb.70166 · Cited by 3
Labordiagnostik des Testosterons
Trottmann, M., Dickmann, M., Stief, C. G., & Becker, A. J. (2010) · Der Urologe · doi:10.1007/s00120-009-2192-0 · Cited by 2
Influence of a transscrotal testosterone propionate administration on the serum level of selected hormones of the hypophyso-gonadal axis
Brisson, G. R., Sáinz, Á. G., Ayotte, C., GAREAU, R., Senécal, L., & Castillo, M. J. (1997) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00019-8 · Cited by 2
Age-related Sleep Alterations: Implications for Endocrine Function
Copinschi, G., & Caufriez, A. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.03.010 · Cited by 2
Testosterone: clinical relevance in ageing men
Huupponen, R., Huhtaniemi, I. T., & Lehtonen, A. (2009) · Reviews in Clinical Gerontology · doi:10.1017/s0959259809990372 · Cited by 2
Differentiation of gonadotropin and sex hormone levels in 50, 60 and 70-year old men. An attempt to indicate a normal range
Kaczmarek, M., & Skrzypczak, M. (2005) · Cited by 2
CLINICAL PRACTICE GUIDELINE Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · Cited by 2
Circadian Regulation of Endocrine Functions
Butler, M. P., Karatsoreos, I. N., Kriegsfeld, L. J., & Silver, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00012-2 · Cited by 2
Congenital Hypogonadotropic Hypogonadism in Males: Clinical Features and Pathophysiology
Balasubramanian, R., & Crowley, W. F. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-53298-1_5 · Cited by 2
Self-citation
Endocrinology
Goldenberg, N., & Kumagai, A. K. (2008) · Elsevier eBooks · doi:10.1016/b978-141603000-3.10009-7 · Cited by 2
Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men
Naveed, A., Lippincott, M. F., Stamou, M., Balasubramanian, R., Bryant, N. K., & Seminara, S. B. (2026) · HORMONES · doi:10.1007/s42000-026-00795-y · Cited by 1
Hypogonadismes hypogonadotrophiques chez l'homme
Young, J. (2004) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(04)74272-9 · Cited by 1
Testicular hormones
Huhtaniemi, I. T. (2011) · doi:10.1093/med/9780199235292.003.9025 · Cited by 1
The effect of exercise order on testosterone and cortisol responses to lower and upper body resistance training exercises
Miller, J. D. (2012) · J. Willard Marriott Library · doi:10.26053/0h-nm22-vhg0 · Cited by 1
Androgen insufficiency in ageing men: how is it defined and should it be treated?
Coates, P. S. (2005) · Europe PMC (PubMed Central) · Cited by 1
Risk of hypogonadism in male survivors of childhood cancer
Ahern, T., & Hayes, F. J. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.277 · Cited by 1
Management of hypogonadotropic hypogonadism in men with failed puberty
Fahmy, I., & Abdelsalam, M. A. M. (2016) · Human Andrology · doi:10.1097/01.xha.0000479441.49042.58 · Cited by 1
Estimation of Sex Hormone, Blood Profiling, and Histopathological Analysis after Treatment with the Biofield Energy Treated Proprietary Test Formulation in Unpredictable Chronic Stress (UCS)- Induced Sprague Dawley Rats
Jana, S. (2021) · Annals of Immunology & Immunotherapy · doi:10.23880/aii-16000137
The critical role of signal quality: Lessons from pulsatile GnRH pathophysiology and clinical applications
Filicori, M. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-287960-9.50035-6 · Cited by 1
Daytime variations of serum testosterone and luteinizing hormone in captive thick-tailed bush babies (Galago garnetti)
Ojoo, R. O., Otiang’a-Owiti, G. E., ODUOR‐OKELO, D., & Wango, E. O. (1994) · Primates · doi:10.1007/bf02382056 · Cited by 1
Troubles de la fertilité d'origine endocrinienne
Lecomte, P., & Gervaise, N. (2004) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(04)74274-2 · Cited by 1
Androgen Treatment of the Hypogonadal Male
Matsumoto, A. M. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-388-0_16
Critical Determinants of GnRH-Gonadotrope Interactions in the Human
Whitcomb, R. W., & Crowley, W. F. (1992) · Springer eBooks · doi:10.1007/978-1-4612-2916-2_1
Self-citation
Diagnóstico e Tratamento do Hipogonadismo Masculino Tardio
Alves, M., Neves, C., & Medina, J. L. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
For information on reprint requests of more than 101 and commercial reprints contact
Barbour, L. A., Cobin, R. H., DeGroot, L. J., Glinoer, D., Mandel, S. J., & Edwards, H. A. (2008)
Hypogonadal or Not Hypogonadal: That is the Question
Winters, S. J. (1998) · Endocrine Practice · doi:10.4158/ep.4.6.423
Compréhension de l’anatomie et des fonctions normales
Meinhardt, A., Giwercman, Y. L., Nordenskjöld, A., Bergmann, M., Baldo, O., Ian Eardley, C., Schuppe, H., Comhaire, F. H., Mahmoud, A., & Tournaye, H. J. (2008) · Springer eBooks · doi:10.1007/978-2-287-72080-2_18
Effects of Androgen Deficiency and Replacement on Male Fertility
Kramer, A. C. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-179-0_8
Sexual dysfunction : the roles of yohimbine hydrochloride and intracavernosal vasoactive drugs in the treatment of erectile dysfunction, the effect of transurethral resection of prostate on sexual functions and the impact of dihydrotestosterone on andropausal symptoms
Kunelius, P. (1999)
Gonadotropin Interpretation in a 25-Year-Old Man
Kashanian, J. A., & Brannigan, R. E. (2016) · JAMA · doi:10.1001/jama.2015.18157
Pituitary Gonadal Axis in the Male
Corradi, P. F., Corradi, R. B., & Greene, L. W. (2016)
Nutrition and the Pubertal Transition
Santoro, N. F., Polotsky, A. J., Rieder, J., & Pollack, S. E. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00018-8
Assessing Testicular Reserve in the Male Oncology Patient
Kashanian, J. A., & Brannigan, R. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-32973-4_9
Clinical Hormonal Guidelines for the Research of the Endocrinology in Sports and Athletes: Beyond Overtraining Syndrome
Cadegiani, F. (2020) · Springer eBooks · doi:10.1007/978-3-030-52628-3_13
Nutrition and Reproduction
Santoro, N., Polotsky, A. J., Rieder, J., & Kondapalli, L. A. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2758-2.00019-6
Assessing Testicular Reserve in the Male Oncology Patient
Kashanian, J. A., & Brannigan, R. E. (2019) · Springer eBooks · doi:10.1007/978-3-030-02868-8_16
The Hypothalamus-Pituitary in Males in Health and Disease
Winters, S. J. (2025) · Springer eBooks · doi:10.1007/978-3-031-96376-6_7
Clinical Diagnosis of Leydig Cell Dysfunction
Swerdloff, R. S., & Wang, C. (2025) · Springer eBooks · doi:10.1007/978-3-031-96376-6_16
Comprensione dell’anatomia e delle funzioni normali
Meinhardt, A., Giwercman, A., Nordenskjöld, A., Bergmann, M., Baldo, O., Ian Eardley, C., Comhaire, F. H., Mahmoud, A., Schuppe, H., & Tournaye, H. J. (2010) · Springer eBooks · doi:10.1007/978-88-470-1487-9_18

Authors: Spratt, D. I., O'Dea, L. S., Schoenfeld, D., Butler, J., Rao, P. N., & Crowley, W. F.
Affiliations: Massachusetts General Hospital (US)
ORCID: Spratt, D. I.
Schoenfeld, D.
Butler, J.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 1988-05-01
Volume: 254
Issue: 5
Pages: E658-E666
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.1988.254.5.e658
OpenAlex: W1882996427
Cited by: 194
References: 31
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 12 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 9
FWCI: 4.48
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Center for Research Resources (RR-1066)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD15788, R01HD015788, T32HD007396, HD 18169, P30HD028138, U54HD028138)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: hypothalamic-pituitary-gonadal axis, luteinizing hormone secretion, follicle-stimulating hormone secretion, testosterone secretion, pulsatile hormone secretion, LH pulse amplitude, diurnal variation, relative refractory period, normal men
MeSH terms: Adult, Blood Specimen Collection, Chronobiology Phenomena, Circadian Rhythm, Follicle Stimulating Hormone, Humans, Hypothalamo-Hypophyseal System, Luteinizing Hormone, Male, Reference Values, Testis, Testosterone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks