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Cited by 317Hypothalamic control of reproductive hormonesCircadian rhythm and melatoninSleep and Wakefulness Research

Human puberty. Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep

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Boyar, R. M., Rosenfeld, R. S., Kapen, S., Finkelstein, J. W., Roffwarg, H. P., Weitzman, E. D., Hellman, Leon·1974·Journal of Clinical Investigation
DOI 10.1172/jci107798PMC PMC301594
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Abstract

Plasma luteinizing hormone (LH) and testosterone (T) were measured by radioimmunoassay in nine pubertal boys and three sexually mature young men at 20-min intervals for 24 h. Plasma LH and T were also measured in one boy during a delayed sleep onset study. Polygraphic monitoring was carried out to identify precisely sleep onset. Wakefulness, and specific sleep stages. In all nine pubertal boys the plasma T concentration fluctuated and was significantly higher during normal nocturnal sleep as compared to daytime waking. This increased T secretion during sleep was temporally linked to the characteristic pubertal sleep augmentation of LH secretion. To define further the relationship of this increased T secretion to sleep, plasma LH and T were also measured in three of the pubertal boys after acute (1-day) reversal of the sleep-wake cycle. One of these boys was also studied after 3 days of sleep-wake cycle reversal. The results of these studies showed that plasma T was now augmented during the reversed daytime sleep period; the mean T concentrations during this period were significantly higher (P < 0.001) than during nocturnal waking in all four studies. Measurement of plasma LH and T in the three sexually mature young men showed episodic secretion of LH and T during both waking and sleep periods; there was no consistent significant augmentation of LH or T secretion during sleep. This study demonstrates that (a) in normal pubertal boys and sexually mature young men plasma T fluctuates episodically; (b) there is marked augmentation of T secretion during sleep in pubertal boys, which is dependent on increased LH secretion; (c) this pubertal LH-T secretory "program" is dependent on sleep, since it shifts with delayed sleep onset and reversal of the sleep-wake cycle; and (d) this demonstrable tropic effect of LH on T is evident only during puberty, since sexually mature young men fail to show any consistent relationship between LH and T secretion either awake or asleep.

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  • A small subset of men with FHH exhibited a sleep-entrained pulse pattern characteristic of early puberty.

    “A small subset of men with FHH exhibited a sleep-entrained pulse pattern characteristic of early puberty (Figs.123) (46), and this”

    From Functional Hypogonadotropic Hypogonadism in Men: Underlying Neuroendocrine Mechanisms and Natural History (2019) · cites this paper as [46]

    The Discussion (page unavailable) describes sleep-synchronized pulsatile LH secretion as characteristic of puberty, supporting the comparison to an early-pubertal pattern. But the Methods describe healthy pubertal boys and normal young men, and the paper does not report a subset of men with FHH exhibiting that pattern. (LLM, conf=0.83)

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Authors
Boyar, R. M., Rosenfeld, R. S., Kapen, S., Finkelstein, J. W., Roffwarg, H. P., Weitzman, E. D., & Hellman, L.
Affiliations
Montefiore Medical Center (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1974-09-01
Volume
54
Issue
3
Pages
609-618
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci107798
PMC
PMC301594
OpenAlex
W2046659727
Cited by
317
References
38
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 9 · 2016: 11 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 5
FWCI
15.63
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
puberty, luteinizing hormone, testosterone, sleep, nocturnal hormone secretion, sleep onset delay, pubertal boys
MeSH terms
Adolescent, Adult, Central Nervous System, Child, Electroencephalography, Humans, Luteinizing Hormone, Male, Periodicity, Puberty, Radioimmunoassay, Secretory Rate, Sleep, Sleep Deprivation, Testosterone, Time Factors

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