CoChat
Sign Up
Cited by 137Metabolism, Diabetes, and CancerMuscle metabolism and nutritionCardiovascular and exercise physiology

The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.

Hepatic fuel metabolism during muscular work: role and regulation

Wasserman, D. H., Cherrington, A. D.·1991·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1991.260.6.e811
Open this paper in CoChat — free account

Abstract

The increased fuel demands of the working muscle necessitate that metabolic processes within the liver be accelerated accordingly. The sum of changes in hepatic glycogenolysis and gluconeogenesis are closely coupled to the increase in glucose uptake by the working muscle, due to the actions of the pancreatic hormones. The exercise-induced rise in glucagon and fall in insulin interact to stimulate hepatic glycogenolysis, whereas the increase in gluconeogenesis is determined primarily by glucagon action. The increment in gluconeogenesis is caused by increases in hepatic gluconeogenic precursor delivery and fractional extraction as well as in the efficiency of intrahepatic conversion to glucose. Glucagon stimulates the latter two processes. Epinephrine may become important in the regulation of hepatic glucose production during prolonged or heavy exercise when its levels are particularly high. On the other hand, there is no evidence that hepatic innervation is essential for the rise in hepatic glucose production during exercise. Nonesterified fatty acid (NEFA) delivery to, uptake of, and oxidation by the liver are accelerated during prolonged exercise, resulting in an increase in ketogenesis. The rate of the first two of these processes is largely determined by factors that stimulate fat mobilization. The third step is regulated by both NEFA delivery to and glucagon-stimulated fat oxidation within the liver. The increase in hepatic fat oxidation produces energy that fuels glucone…

Overview

Integrity signals

Registry

Crossref · 10.1152/ajpendo.1991.260.6.e811

Cites

82 of 82 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Citations

Cites

2 retracted

Show all 82 references

Research works printed but not linked: 27

  1. AHLBORG G., 1977, Metab. Gastrointest. Physiol. 2), E188
  2. ARNALL D. A., 1986, Metab. 13), E641
  3. BJORKMAN O., 1983, Metab. 8), E443
  4. CARRARO F., W., 1990, Metab. 21), E821
  5. CHERRINGTON A. D., 1979, Metab. Gastrointest. Physiol. 5), E263
  6. COOPER D. M., 1989, Metab. 20), E405
  7. FURY F., 1986, Metab. 13), E495
  8. GEER R. J., 1987, Surg. Forum, 38, 27
  9. HIRSH I., J., 1989, Diabetes, 38, 83A
  10. ISSEKUTZ B, J. Appl. Physiol., 44, 1978
  11. RENNIE M. J., AND J. 0. HOLLOSZY. A sparing
  12. 1985, Exp., 34, 431
  13. JENKINS A. B., 1986, Physiol. 19), R411
  14. KJAER M., N., 1987, Physiol. 22), R687
  15. LAVOIE J.-M., 1989, Metab. 20), E855
  16. MARKER J. C., 1986, Physiol. 20), R552
  17. MOATES J. M., 1988, Metab. 18), E428
  18. SACCA L. C., 1983, Metab. 8), E294
  19. SAWCHENKO P. E., 1979, Physiol. 5), R5
  20. SESTOFT L., J., 1977, Clin. Sci. Mol. Med., 53, 411
  21. SHI Z., K., 1990, Diabetes, 39, 22A, 10.2337/diacare.39.1.22 · DOI
  22. SIREK A., M, Am. J. Physiol., 237
  23. VISSING J., J., 1989, Physiol. 25), R1019
  24. VRANIC M., D., 1990, Rifkin and D. Porte. New York: Elsevier Science, 198
  25. WASSERMAN D. H., 1990, Diabetes, 39, 89A
  26. WASSERMAN D. H., 1990, Metab. 22), E195
  27. WASSERMAN D. H., 1988, Metab. 17), E518

Cited by

Sorted by citations

Items 101–136 of 136

Related

See all

Metadata

Authors
Wasserman, D. H., & Cherrington, A. D.
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1991-06-01
Volume
260
Issue
6
Pages
E811-E824
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1991.260.6.e811
OpenAlex
W1932762496
Cited by
137
References
82
Citations by year
2026: 1 · 2024: 4 · 2023: 8 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 5
FWCI
0.29
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
hepatic glucose production, physical activity, hepatic glycogenolysis, gluconeogenesis, glucagon, insulin, epinephrine, free fatty acids, ketogenesis, amino acid metabolism, muscle glucose uptake, pancreatic hormones, hepatic innervation, lipid mobilization
MeSH terms
Animals, Energy Metabolism, Epinephrine, Physical Exertion, Glucagon, Homeostasis, Insulin, Liver, Models, Biological, Muscles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review