Regulation of hepatic fatty acid oxidation and ketone body production
Abstract
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
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Glucagon stimulates hepatic glycogenolysis and ketogenesis, and decreased insulin suppresses hepatocyte malonyl-CoA synthesis and lipogenesis, with concomitant activation of fatty acid oxidation.
“Glucagon stimulates hepatic glycogenolysis and ketogenesis, and the decrease in insulin suppresses hepatocyte malonyl-coenzyme A (CoA) synthesis and lipogenesis, with concomitant activation of FAO (21, 22).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [22]
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“264 Cell Metabolism 25, February 7, 2017 convert mitochondrial acetyl-CoA to transportable metabolites, inhibits fatty acid oxidation: acetyl-CoA carboxylase (ACC) catalyzes the conversion of acetyl-CoA to malonyl-CoA, the lipogenic substrate and allosteric inhibitor of mitochondrial CPT1 (reviewed in Kahn et al., 200…”
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“Abbreviations Apo B : apolipoprotein B ASH : alcoholic steatohepatitis AZT : zidovudine Bid : BH3 interacting domain death agonist CPT-I : carnitine palmitoyltransferase I CYP : cytochrome P450 DdI : didanosine d4T : stavudine FFA : free fatty acid 4-HNE : 4-hydroxynonenal IL-8 : interleukin-8 MDA : malondialdehyde Mn…”
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Toshimitsu, K., Matsuura, B., Ohkubo, I., Niiya, T., Furukawa, S., Hiasa, Y., Kawamura, M., Ebihara, K., & Onji, M. (2006) · Nutrition · doi:10.1016/j.nut.2006.09.004 · Cited by 264 · see citing works
Cappel, D. A., Deja, S., Duarte, J. A. G., Kucejova, B., Iñigo, M., Fletcher, J. A., Fu, X., Berglund, E. D., Liu, T., Elmquist, J. K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.014 · Cited by 242 · see citing works
“To more specifically examine β-oxidation, we measured ketones, which represent the predominant fate of hepatic acetyl-CoA in the fasted state (McGarry and Foster, 1980; Puchalska and Crawford, 2017).”
BackgroundThe brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis
Wolfgang, M. J., Kurama, T., Dai, Y., Suwa, A., Asaumi, M., Matsumoto, S.-I., Cha, S. H., Shimokawa, T., & Lane, M. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602205103 · Cited by 250 · see citing works
Luukkonen, P. K., Dufour, S., Lyu, K., Zhang, X., Hakkarainen, A., Lehtimäki, T. E., Cline, G. W., Petersen, K. F., Shulman, G. I., & Yki‐Järvinen, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922344117 · Cited by 253 · see citing works
“Nonprotein respiratory quotient (NPRQ) was calculated assuming that 1 g of protein requires 966 mL O2 and produces 782 mL CO2.”
BackgroundInfluentialDe novo lipogenesis in humans: metabolic and regulatory aspects
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“Malonyl-CoA inhibits transport of FA-CoAs into mitochondria by inhibiting carnitine acyl-transferase I activity (McGarry & Foster, 1980).”
BackgroundInfluentialHarwood, H. J., Petras, S. F., Shelly, L. D., Zaccaro, L. M., Perry, D. A., Makowski, M. R., Hargrove, D. M., Martin, K. A., Tracey, W. R., Chapman, J. G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304481200 · Cited by 242 · see citing works
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“The combination of higher insulin concentrations, reduced fatty acid availability to tissues with increased delivery of extracellular glucose, and a lipogenic, presumably antiketogenic milieu (33) in the liver (all measured in this study), and increased intracellular glycogen stores (presumed) might explain the marked…”
BackgroundMinireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes
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DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome
Mercer, J. R., Cheng, K., Figg, N. L., Gorenne, I., Mahmoudi, M., Griffin, J. L., Vidal‐Puig, A., Logan, A., Murphy, M. P., & Bennett, M. R. (2010) · Circulation Research · doi:10.1161/circresaha.110.218966 · Cited by 240 · see citing works
CONTROL OF ELECTRON FLUX THROUGH THE RESPIRATORY CHAIN IN MITOCHONDRIA AND CELLS
Brand, M. D., & Murphy, M. P. (1987) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1987.tb01265.x · Cited by 240 · see citing works
“The only important allosteric control on fatty acid catabolism that is known is the potent inhibitory effect of malonyl-CoA on the carnitine palmitoyltransferase situated on the outer face of the inner mitochondrial membrane (McGarry, Takabayashi & Foster, 1978; McGarry & Foster, 1980).”
BackgroundFacchini, F. S., Hua, N. W., & Stoohs, R. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.32403 · Cited by 233 · see citing works
- Authors
- McGarry, J. D., & Foster, D. W.
- ORCID
- McGarry, J D
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1980-06
- Volume
- 49
- Issue
- 1
- Pages
- 395-420
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2178164598
- Cited by
- 1,460
- References
- 0
- Citations by year
- 2026: 14 · 2025: 28 · 2024: 30 · 2023: 41 · 2022: 39 · 2021: 25 · 2020: 42 · 2019: 47 · 2018: 26 · 2017: 27 · 2016: 33 · 2015: 28 · 2014: 36 · 2013: 35 · 2012: 24
- FWCI
- 47.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- hepatic fatty acid oxidation, ketone synthesis, Hippo signaling pathway, hepatic metabolism, tissue growth regulation, organ size control, cell fate determination
- MeSH terms
- Acetyl Coenzyme A, Adipose Tissue, Animals, Carnitine, Carnitine Acyltransferases, Fatty Acids, Fatty Acids, Nonesterified, Glucagon, Glycogen, Insulin, Ketone Bodies, Liver, Malonyl Coenzyme A, Models, Biological, Triglycerides, Meglutol
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