Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism
Abstract
This study was undertaken to investigate the effects of chronic physiological elevations in plasma cortisol on glycogenolysis and gluconeogenesis in conscious, overnight-fasted dogs. Experiments consisted of an 80-min tracer and dye equilibration period and a 40-min sampling period. Infusions of D-[3-3H]glucose, L-[U-14C]alanine, and indocyanine green dye were used to assess glucose production (Ra) and gluconeogenesis using tracer and arteriovenous (a-v) difference techniques. In the cortisol group, (n = 10), a continuous infusion of hydrocortisone (3.5 micrograms.kg-1 x min-1) was begun 5 days before the experiment and continued throughout the sampling period. In the saline group (n = 10), there was no infusion of cortisol. The fivefold elevation in plasma cortisol increased plasma insulin from 12 +/- 2 to 19 +/- 2 microU/ml. Glucose Ra was elevated in the cortisol group (3.5 +/- 0.2 vs. 2.8 +/- 0.2 mg.kg-1 x min-1) but net hepatic glucose output was markedly diminished (1.2 +/- 0.4 vs. 2.7 +/- 0.3 mg.kg-1 x min-1). Gluconeogenic conversion of alanine to glucose was increased slightly by cortisol (0.60 +/- 0.13 to 0.99 +/- 0.12 mumol.kg-1 x min-1), but the gluconeogenic efficiency of the liver was unchanged. Cortisol increased hepatic glycogen content evident at the end of the study greater than twofold (76.4 +/- 7.9 vs. 30.0 +/- 4.7 g/liver). These results suggest that cortisol 1) promotes glucose cycling through glycogen, 2) greatly inhibits nonhepatic glucose utilization, 3) increases hepatic gluconeogenesis in vivo primarily through enhanced substrate delivery to the liver, and 4) raises plasma insulin levels, which restrains intrahepatic gluconeogenesis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Excess cortisol induces hepatic and extrahepatic insulin resistance and alters insulin action.
“Previous studies have demonstrated that excess cortisol induces hepatic and extrahepatic insulin resistance (3,18,20,28,41,42,48).”
From Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects (2004) · cites this paper as [20]
Studies in overnight-fasted dogs showed that a fivefold elevation in plasma cortisol resulted in minimally elevated rates of gluconeogenesis despite increased plasma insulin and glucose concentrations.
“This conclusion is supported by studies in overnight-fasted dogs in which a fivefold elevation in plasma cortisol resulted in minimally elevated rates of gluconeogenesis despite increased plasma insulin and glucose concentrations (20).”
From Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects (2004) · cites this paper as [20]
Cites
Greenway, C. V., & Stark, R. D. (1971) · Physiological Reviews · doi:10.1152/physrev.1971.51.1.23 · Cited by 638 · see citing works
ON THE HORMONAL REGULATION OF CARBOHYDRATE METABOLISM; STUDIES WITH C14 GLUCOSE.
DeBodo, R. C., Steele, R., ALTSZULER, N., Dunn, A., & Bishop, J. (1963) · PubMed · Cited by 532 · see citing works
Chan, T. M., & Exton, J. H. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90014-2 · Cited by 416 · see citing works
Regulation of Hepatic Metabolism
(1986) · Springer eBooks · doi:10.1007/978-1-4684-5041-5 · Cited by 414 · see citing works
Tracers in metabolic research: radioisotope and stable isotope/mass spectrometry methods.
Wolfe, R. R. (1984) · PubMed · Cited by 220 · see citing works
Adkins, B., Myers, S. R., Hendrick, G. K., Stevenson, R. W., Williams, P. E., & Cherrington, A. D. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112847 · Cited by 179 · see citing works
Self-citationMultihormonal Regulation of Phosphoenolpyruvate Carboxykinase Gene Transcription
Granner, D. K., Sasaki, K., & Chu, D. T. W. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb15530.x · Cited by 132 · see citing works
Glucose turnover values in the dog obtained with various species of labeled glucose
ALTSZULER, N., Barkai, A., Bjerknes, C. A., Gottlieb, B., & Steele, R. (1975) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1975.229.6.1662 · Cited by 131 · see citing works
Gluconeogenesis: methodological approaches in vivo.
Chiasson, J. L., LILJENQUIST, J. E., LACY, W. W., As, J., & Cherrington, A. D. (1977) · PubMed · Cited by 120 · see citing works
Self-citationHormone-Substrate Interrelationships Following Trauma
Meguid, M. M. (1974) · Archives of Surgery · doi:10.1001/archsurg.1974.01360060046013 · Cited by 111 · see citing works
Characteristics and Hormonal Regulation of Amino Acid Transport System A in Isolated Rat Hepatocytes
Kilberg, M. S., Barber, E. F., & Handlogten, M. E. (1985) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152825-6.50009-6 · Cited by 108 · see citing works
Interaction of adrenal steroids and glucagon on gluconeogenesis in perfused rat liver
Friedmann, N. K., Exton, J. H., & Park, C. R. (1967) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(67)90550-5 · Cited by 104 · see citing works
The Roles of Insulin, Glucagon, and Free Fatty Acids in the Regulation of Ketogenesis in Dogs
Keller, U. B., Chiasson, J., LILJENQUIST, J. E., Cherrington, A. D., Jennings, A. S., & Crofford, O. B. (1977) · Diabetes · doi:10.2337/diab.26.11.1040 · Cited by 83 · see citing works
Self-citationEffect of catecholamines and methylprednisolone on carbohydrate metabolism of dogs
Issekutz, B., Jr., & Allen, M. (1972) · Metabolism · doi:10.1016/0026-0495(72)90019-4 · Cited by 80 · see citing works
A Molecular Order in the Synthesis and Degradation of Glycogen in the Liver
Devos, P. E., & Hers, H. G. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb13242.x · Cited by 75 · see citing works
Adkins-Marshall, B. A., Myers, S. R., Hendrick, G. K., Williams, P. E., Triebwasser, K. C., Floyd, B., & Cherrington, A. D. (1990) · Diabetes · doi:10.2337/diacare.39.1.87 · Cited by 63 · see citing works
Self-citationCarbohydrate metabolism in perfused livers of adrenalectomized and steroid-replaced rats
Exton, J. H., Miller, T. P., Harper, S. C., & Cr, P. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.230.1.163 · Cited by 56 · see citing works
In Vivo Regulation of Non-Insulin-Mediated and Insulin-Mediated Glucose Uptake by Cortisol
Baron, A. D., Wallace, P., & Brechtel, G. (1987) · Diabetes · doi:10.2337/diab.36.11.1230 · Cited by 56 · see citing works
Effects of insulin on glucagon-stimulated glucose production in the conscious dog
Steiner, K., Williams, P. E., LACY, W. W., & Cherrington, A. D. (1990) · Metabolism · doi:10.1016/0026-0495(90)90192-f · Cited by 46 · see citing works
Self-citationRelationship between FFA flux and TGFA influx in plasma before and during the infusion of insulin
Nestel, P. J. (1967) · Metabolism · doi:10.1016/0026-0495(67)90058-3 · Cited by 38 · see citing works
Steroidal Influences on Catecholamines
Harrison, T. S., Chawla, R. C., & Wojtalik, R. S. (1968) · New England Journal of Medicine · doi:10.1056/nejm196807182790305 · Cited by 36 · see citing works
The Relationship of Insulin Production to Glucose Metabolism in Severe Sepsis
Dahn, M. S. (1985) · Archives of Surgery · doi:10.1001/archsurg.1985.01390260036006 · Cited by 35 · see citing works
Issekutz, B., Jr., & Borkow, I. (1973) · Metabolism · doi:10.1016/0026-0495(73)90027-9 · Cited by 29 · see citing works
Hepatic glycogen in humans. II. Gluconeogenetic formation after oral and intravenous glucose
Radziuk, J. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.2.e158 · Cited by 28 · see citing works
Metabolic effects of cortisol in man—Studies with somatostatin
Johnston, D. G., Gill, A., Ørskov, H., Batstone, G. F., & Alberti, K. G. M. M. (1982) · Metabolism · doi:10.1016/0026-0495(82)90105-6 · Cited by 27 · see citing works
Non-insulin-mediated glucose uptake predominates in postabsorptive dogs
Lavelle-Jones, M., Scott, M. H., Kolterman, O., Moossa, A. R., & Olefsky, J. M. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.252.5.e660 · Cited by 12 · see citing works
Badder, E. M., Santen, R. T., SAMOJLIK, E., & Harrison, T. (1980) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cortisol in teleosts: dynamics, mechanisms of action, and metabolic regulation
Mommsen, T. P., Vijayan, M. M., & Moon, T. W. (1999) · Reviews in Fish Biology and Fisheries · doi:10.1023/a:1008924418720 · Cited by 2,330 · see citing works
Landys, M. M., Ramenofsky, M., & Wingfield, J. C. (2006) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2006.02.013 · Cited by 846 · see citing works
THE IMPACT OF PREDATOR-INDUCED STRESS ON THE SNOWSHOE HARE CYCLE
Boonstra, R., Hik, D. S., Singleton, G. R., & Tinnikov, A. A. (1998) · Ecological Monographs · doi:10.1890/0012-9615(1998)068[0371:tiopis]2.0.co;2 · Cited by 587 · see citing works
Adrenocortical Responses to Stress and Their Modulation in Free‐Living Vertebrates
Wingfield, J. C., & Romero, L. M. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070411 · Cited by 461 · see citing works
Update on Bispectral Index monitoring
Johansen, J. W. (2006) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2005.08.004 · Cited by 308 · see citing works
Romero, L. M., & Remage‐Healey, L. (2000) · General and Comparative Endocrinology · doi:10.1006/gcen.2000.7491 · Cited by 255 · see citing works
Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome
KHANI, S., & TAYEK, J. A. (2001) · Clinical Science · doi:10.1042/cs1010739 · Cited by 259 · see citing works
Effect of Nitrous Oxide on Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures
Mennerick, S. J., Jevtović‐Todorović, V., Todorovic, S. M., Shen, W., Olney, J. W., & Zorumski, C. F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09716.1998 · Cited by 225 · see citing works
Tempel, D. L., & LEIBOWITZ, S. F. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00611.x · Cited by 203 · see citing works
Larsen, B., Seitz, A., & Larsen, R. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200001000-00035 · Cited by 172 · see citing works
Evidence that carotid bodies play an important role in glucoregulation in vivo.
Koyama, Y., Coker, R. H., Stone, E. E., Lacy, D. B., Jabbour, K., Williams, P. E., & Wasserman, D. H. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1434 · Cited by 151 · see citing works
Self-citationNovel Aspects of Glucocorticoid Actions
Uchôa, E. T., Aguilera, G., Herman, J. P., Fiedler, J. L., Deak, T., & de Sousa, M. B. C. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12157 · Cited by 144 · see citing works
PHYSIOLOGIC RESPONSES OF GRIZZLY BEARS TO DIFFERENT METHODS OF CAPTURE
Cattet, M., Christison, K. M., Caulkett, N., & Stenhouse, G. B. (2003) · Journal of Wildlife Diseases · doi:10.7589/0090-3558-39.3.649 · Cited by 124 · see citing works
Sawamura, S., Kingery, W. S., Davies, M. F., Agashe, G. S., Clark, J. D., Kobilka, B. K., Hashimoto, T., & Maze, M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09242.2000 · Cited by 135 · see citing works
Wilson, K., Girdler, N. M., & Welbury, R. R. (2003) · British Journal of Anaesthesia · doi:10.1093/bja/aeg278 · Cited by 110 · see citing works
Bonner, J. S., Lantier, L., Hasenour, C. M., James, F. D., Bracy, D. P., & Wasserman, D. H. (2013) · Diabetes · doi:10.2337/db12-0354 · Cited by 107 · see citing works
Self-citationPoscia, A., Mascini, M., Moscone, D., Luzzana, M., Caramenti, G., Cremonesi, P., Valgimigli, F., Bongiovanni, C., & Varalli, M. (2003) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(02)00216-6 · Cited by 101 · see citing works
DEFECTIVE GLUCOSE HOMEOSTASIS DURING INFECTION
McGuinness, O. P. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132159 · Cited by 100 · see citing works
Self-citationLandys, M. M., Wingfield, J. C., & Ramenofsky, M. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.06.006 · Cited by 92 · see citing works
Burnweit, C. A., Zerpa, J., Nahmad, M., Lankau, C. A., Weinberger, M., Malvezzi, L., Smith, L., Shapiro, T., & Thayer, K. (2004) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2003.11.037 · Cited by 90 · see citing works
Castéra, L., Nègre, I., Samii, K., & Buffet, C. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03776.x · Cited by 84 · see citing works
Wilson, K. E., Welbury, R. R., & Girdler, N. M. (2002) · Anaesthesia · doi:10.1046/j.1365-2044.2002.02784.x · Cited by 77 · see citing works
Hormonal stimulation of hepatocyte metabolism in rainbow trout following an acute handling stress
Vijayan, M. M., Pereira‐Wilson, C., & Moon, T. W. (1994) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/0742-8413(94)00024-5 · Cited by 76 · see citing works
Preemptive Analgesia at the Crossroad
Kissin, I. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000144429.39988.9b · Cited by 75 · see citing works
Champagne, C. D., Houser, D. S., & Crocker, D. E. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01476 · Cited by 73 · see citing works
Insulin resistance: lifestyle and nutritional interventions.
Kelly, G. S. (2000) · PubMed · Cited by 71 · see citing works
Daily and Seasonal Variation in Response to Stress in Captive Starlings (Sturnus Vulgaris): Glucose
Remage‐Healey, L., & Romero, L. M. (2000) · General and Comparative Endocrinology · doi:10.1006/gcen.2000.7492 · Cited by 69 · see citing works
A comparison of oral midazolam and nitrous oxide sedation for dental extractions in children
Wilson, K. E., Girdler, N. M., & Welbury, R. R. (2006) · Anaesthesia · doi:10.1111/j.1365-2044.2006.04835.x · Cited by 67 · see citing works
Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma
Chan, C., Francois Berthiaume, B., Lee, K., & Yarmush, M. L. (2003) · Metabolic Engineering · doi:10.1016/s1096-7176(02)00011-3 · Cited by 64 · see citing works
Neuropeptide Y in relation to carbohydrate intake, corticosterone and dietary obesity
Wang, J., Akabayashi, A., Dourmashkin, J. T., Yu, H. J., Alexander, J. T., Chae, H. J., & LEIBOWITZ, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00551-4 · Cited by 61 · see citing works
Contemporary dental photography: selection and application.
Terry, D. A., Snow, S. R., & McLaren, E. A. (2008) · PubMed · Cited by 56 · see citing works
Nielsen, M. F., Caumo, A., Chandramouli, V., Schumann, W. C., Cobelli, C., Landau, B. R., Vilstrup, H., Rizza, R. A., & Schmitz, O. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00566.2002 · Cited by 53 · see citing works
Leitch, J., Anderson, K., Gambhir, S., Millar, K., Robb, N. D., McHugh, S., & Kenny, G. N. C. (2004) · Anaesthesia · doi:10.1111/j.1365-2044.2004.03761.x · Cited by 51 · see citing works
Effects of glucocorticoids on hepatic sensitivity to insulin and glucagon in man
Dirlewanger, M., Schneiter, P., Paquot, N., Jéquier, E., Rey, V., & Tappy, L. (2000) · Clinical Nutrition · doi:10.1054/clnu.1999.0064 · Cited by 52 · see citing works
Chacko, S. K., Ordonez, J. M., Sauer, P. J. J., & Sunehag, A. L. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.12.040 · Cited by 48 · see citing works
Cardiovascular effects of xenon and nitrous oxide in patients during fentanyl‐midazolam anaesthesia*
Goto, T., Hanne, P., Ishiguro, Y., Ichinose, F., Niimi, Y., & Morita, S. (2004) · Anaesthesia · doi:10.1111/j.1365-2044.2004.03900.x · Cited by 45 · see citing works
Nitrous oxide-oxygen or oral midazolam for pediatric outpatient sedation
Hulland, S. A., Freilich, M. M., & Sándor, G. K. B. (2002) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1067/moe.2002.124763 · Cited by 40 · see citing works
Reproductive outcomes among dental personnel: a review of selected exposures.
Olfert, S. M. (2006) · PubMed · Cited by 34 · see citing works
Marissal‐Arvy, N., Gaumont, A., Langlois, A., Dabertrand, F., Bouchecareilh, M., Tridon, C., & Mormède, P. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0077 · Cited by 34 · see citing works
Hernández-Pérez, J., Naderi, F., Chivite, M., Soengas, J. L., Míguez, J. M., & López‐Patiño, M. A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00611 · Cited by 31 · see citing works
Scheuer, B. H., Zbinden, Y., Schneiter, P., Tappy, L., Blum, J. W., & Hammon, H. M. (2005) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.11.004 · Cited by 32 · see citing works
Goldstein, R. E., Rossetti, L., Palmer, B. A., Liu, R., Massillon, D., Scott, M. F., Neal, D. W., Williams, P. J., Peeler, B. B., & Cherrington, A. D. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00320.2002 · Cited by 31 · see citing works
Self-citationCollado, V., Hennèquin, M., Faulks, D., Mazille, M.-N., Nicolas, E., Koscielny, S., & Onody, P. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000236660.01039.eb · Cited by 32 · see citing works
Ouergui, I., Houcine, N., Marzouki, H., Davis, P., Zaouali, M., Franchini, É., Gmada, N., & Bouhlel, E. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001005 · Cited by 31 · see citing works
The metabolic changes caused by dexamethasone in the adjuvant-induced arthritic rat
Caparroz‐Assef, S. M., Bersani‐Amado, C. A., Kelmer-Bracht, A. M., Bracht, A., & Ishii‐Iwamoto, E. L. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9430-9 · Cited by 30 · see citing works
Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs
Moore, M. C., Kimura, K., Shibata, H., Honjoh, T., Saito, M., Everett, C. A., Smith, M. S., & Cherrington, A. D. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00614.2004 · Cited by 28 · see citing works
Self-citationBerneis, K. K., Ninnis, R., Girard, J., Frey, B. M., & Keller, U. B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4143 · Cited by 28 · see citing works
Barbera, A., Wilkening, R. B., Teng, C. C., Battaglia, F. C., & Meschia, G. (1997) · Pediatric Research · doi:10.1203/00006450-199702000-00015 · Cited by 26 · see citing works
The Prevention and Correction of Hypoglycemia
Cryer, P. E. (2001) · Comprehensive Physiology · doi:10.1002/cphy.cp070235 · Cited by 23 · see citing works
Is decreased appetite for food a physiological consequence of alcohol consumption?
Kokavec, A. (2008) · Appetite · doi:10.1016/j.appet.2008.03.011 · Cited by 22 · see citing works
Growth and development in type 1 diabetes
Koren, D. (2021) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000694 · Cited by 23 · see citing works
Tsai, P., Huang, C., Hung, Y.-C., & Cheng, C.-R. (2001) · PubMed · Cited by 21 · see citing works
Franco-Colín, M., Téllez-López, A. M., Quevedo-Corona, L., & Racotta, R. (2000) · Metabolism · doi:10.1053/meta.2000.9522 · Cited by 21 · see citing works
Panic disorder and hyperventilation
NARD, A. E., Valença, A. M., Nascimento, I., Mezzasalma, M. A., & Zin, W. A. (1999) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x1999000600006 · Cited by 20 · see citing works
Use of nitrous oxide and oxygen for conscious sedation to manage pain and anxiety.
Ryding, H. A., & Murphy, H. J. (2007) · PubMed · Cited by 21 · see citing works
Anxiolytic-like action in mice treated with nitrous oxide and oral triazolam or diazepam
Gries, D. A., Condouris, G. A., Shey, Z., & Houpt, M. I. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.07.028 · Cited by 20 · see citing works
Kokavec, A., & Crowe, S. F. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00606-2 · Cited by 19 · see citing works
Malisch, J. L., Bennett, D. J., Davidson, B. A., Wenker, E. S., Suzich, R. N., & Johnson, E. E. (2018) · Physiological and Biochemical Zoology · doi:10.1086/698536 · Cited by 19 · see citing works
Pencek, R., James, F. D., Lacy, D. B., Jabbour, K., Williams, P. E., Fueger, P. T., & Wasserman, D. H. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3041 · Cited by 19 · see citing works
Self-citationYu, P., Yuan, H., Li, X., & Chen, H. (2024) · Endocrine · doi:10.1007/s12020-024-04043-4 · Cited by 16 · see citing works
Winnick, J. J., Ramnanan, C. J., Saraswathi, V., Roop, J., Scott, M., Jacobson, P. B., Jung, P. M., Basu, R., Cherrington, A. D., & Edgerton, D. S. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00639.2012 · Cited by 16 · see citing works
Self-citationThe role of growth hormone and glucocorticoid in glucose handling in vivo
Johansen, T., Deckert, M., Mandrup-Poulsen, T. R., & Malmlöf, K. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1620087 · Cited by 15 · see citing works
Adeyemi, W. J., & Olayaki, L. A. (2018) · Pathophysiology · doi:10.1016/j.pathophys.2018.02.003 · Cited by 14 · see citing works
Ingesting alcohol prior to food can alter the activity of the hypothalamic-pituitary-adrenal axis
Kokavec, A., Lindner, A. J., Ryan, J. E., & Crowe, S. F. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.05.004 · Cited by 14 · see citing works
Kokavec, A., & Crebbin, S. J. (2010) · Appetite · doi:10.1016/j.appet.2010.09.007 · Cited by 14 · see citing works
Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production
Edgerton, D. S., Jacobson, P. B., Opgenorth, T. J., Zinker, B. A., Beno, D. W. A., von Geldern, T., Öhman, L., Scott, M. F., Neal, D. W., & Cherrington, A. D. (2006) · Metabolism · doi:10.1016/j.metabol.2006.05.011 · Cited by 12 · see citing works
Self-citationSheraton, T. E., Gildersleve, C. D., & Hall, J. E. (2006) · Anaesthesia · doi:10.1111/j.1365-2044.2006.04857.x · Cited by 12 · see citing works
Maternal mindful eating as a target for improving metabolic outcomes in pregnant women with obesity
Lindsay, K. L., Most, J., Buehler, K., Kebbe, M., Altazan, A. D., & Redman, L. M. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/5048 · Cited by 11 · see citing works
Perceptions of dentists, dentistry undergraduate students, and the lay public about dental sedation
Costa, L. R., Dias, A. D., Pinheiro, L. S., Chaves, M. E. P. D. S., Ferreira, R. D. A. R., de Almeida, R. B., & Lima, A. R. D. A. (2004) · Journal of Applied Oral Science · doi:10.1590/s1678-77572004000300004 · Cited by 11 · see citing works
Takahashi, N., Chujo, D., Kajio, H., & Ueki, K. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12949 · Cited by 10 · see citing works
Yoo, K. Y., Jeong, S. T., Ha, I. H., & Lee, A. J. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000058842.05373.e3 · Cited by 81 · see citing works
Gestational experience alters sex allocation in the subsequent generation
Edwards, A. M., Cameron, E. Z., Pereira, J. C., Wapstra, E., Ferguson-Smith, M. A., Horton, S. R., & Thomasson, K. (2016) · Royal Society Open Science · doi:10.1098/rsos.160210 · Cited by 9 · see citing works
Kokavec, A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.022 · Cited by 9 · see citing works
Freeman, R., & Carson, P. (2003) · International Journal of Paediatric Dentistry · doi:10.1046/j.1365-263x.2003.00480.x · Cited by 8 · see citing works
Driver versus navigator causation in biology: the case of insulin and fasting glucose
Diwekar-Joshi, M., & Watve, M. (2020) · PeerJ · doi:10.7717/peerj.10396 · Cited by 7 · see citing works
Antidepressants in social anxiety disorder
Nardi, A. E. (2001) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2001000400032 · Cited by 7 · see citing works
Acute glucocorticoid treatment increases urinary biotin excretion and serum biotin
Rathman, S. C., Lewis, B., & McMahon, R. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00357.2001 · Cited by 7 · see citing works
Overduin, S. L., Killen, S. S., Zimmer, A. M., McCuaig, J. D., Cotgrove, L., Aragao, I., Rozanitis, K., Konhauser, K. O., Alessi, D. S., & Blewett, T. A. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117432 · Cited by 5 · see citing works
Basu, A., YADAV, Y. R., Carter, R. E., & Basu, R. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa241 · Cited by 5 · see citing works
Genomic Effect of Glucocorticoids on Enzymes of Intermediary Metabolism inOreochromis mossambicus
Sunny, F., Jacob, A., & Oommen, O. V. (2003) · Endocrine Research · doi:10.1081/erc-120022293 · Cited by 5 · see citing works
Waladkhani, A. R., & Hellhammer, D. H. (2008) · Advances in clinical chemistry · doi:10.1016/s0065-2423(07)00005-4 · Cited by 4 · see citing works
Does insulin signalling decide glucose levels in the fasting steady state?Preprint
Diwekar-Joshi, M., & Watve, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/553016 · Cited by 4 · see citing works
Murray, B. A., & Machin, K. L. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2023.1229152 · Cited by 3 · see citing works
Insulin and the Physiology of Carbohydrate Metabolism
Pereira, S., & Giacca, A. (2011) · Energy balance and cancer · doi:10.1007/978-1-4419-9911-5_1 · Cited by 3 · see citing works
Zhang, Q., Li, M., Yin, Y., Ge, S., Li, D., Ahmad, I. M., Nabi, G., Sun, Y., Luo, X., & Dongming, L. I. (2023) · Integrative Zoology · doi:10.1111/1749-4877.12709 · Cited by 3 · see citing works
Cardiorespiratory fitness mediates cortisol and lactate responses to winter and summer marches
Pešić, D., Đukić, M., Stanojević, I., Živkovć, V., Bolevich, S., Bolevich, S. S., & Jakovljevic, V. L. (2023) · Journal of Medical Biochemistry · doi:10.5937/jomb0-44369 · Cited by 3 · see citing works
Treating posttransplantation diabetes mellitus
Pérez‐Sáez, M. J., Marín-Casino, M., & Pascual, J. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1039983 · Cited by 3 · see citing works
Moore, M. C., Cherrington, A. D., Palmer, B. A., Lacy, D. B., & Goldstein, R. E. (2000) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607100024004244 · Cited by 3 · see citing works
Self-citationNovel Aspects of Glucocorticoids Actions on Energy Homeostasis and Hydromineral Balance
Ruginsk, S. G., Cesar, R., Borges, B. C., Torres, E., Elias, L. L. K., & Antunes‐Rodrigues, J. (2012) · InTech eBooks · doi:10.5772/53266
Berg, R. M. G., & Pedersen, B. K. (2009) · doi:10.1002/9783527628346.ch18
Estresse pós-privação de sono: análises morfométricas do fígado
Oliveira, M. C., Domingos, N. A. M., Martins, A. T., Azoubel, R., Miyazaki, M. C. D. O. S., Imperial, R. E., Pires, M. D., & de Godoy, M. F. (2013) · ABCS Health Sciences · doi:10.7322/abcshs.v38i2.11
Blood Rheology, Sex Hormones, and Cortisol in Athletes
Melnikov, А. А., & Викулов, А. Д. (2004) · Human Physiology · doi:10.1023/b:hump.0000042619.36197.d5
In vivo estimation of gluconeogenesis
Chacko, S. K. (2011) · University of Groningen research database (University of Groningen / Centre for Information Technology)
Reinstrup, P., Ryding, E., Ohlsson, T., Sandell, A., Erlandsson, K., Ljunggren, K., Salford, L. G., Strand, S., & Uski, T. K. (2008)
Teixeira, L., Duarte, D., & Saraiva, R. Â. (2009)
Interactions between carbohydrate and lipid metabolism in metabolic disorders
Bandsma, R. (2004) · University of Groningen research database (University of Groningen / Centre for Information Technology)
Overduin, S. L., Killen, S. S., Zimmer, A. M., McCuaig, J. D., Cotgrove, L., Aragao, I., Rozanitis, K., Konhauser, K. O., Alessi, D. S., & Blewett, T. A. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4877793
Morgante, C., Cammà, C., PETTA, S., Guarnotta, V., & Arnaldi, G. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.v32.i16.116142
- Authors
- Goldstein, R. E., Wasserman, D. H., McGuinness, O. P., Lacy, D. B., Cherrington, A. D., & Abumrad, N. N.
- Affiliations
- Vanderbilt University (US)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1993-01-01
- Volume
- 264
- Issue
- 1
- Pages
- E119-E127
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2290181424
- Cited by
- 100
- References
- 27
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk030515-07, 5p60dk020593-31)
- National Institute of Diabetes and Digestive and Kidney Diseases (2-RO1-DK-30515, 5P60 DK-20593, 5RO1-DK-18243, R01DK018243)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- cortisol, hepatic glucose production, gluconeogenesis, glycogenolysis, liver glycogen, plasma insulin, dogs
- MeSH terms
- Alanine, Animals, Arteries, Blood Glucose, Dogs, Female, Gluconeogenesis, Glucose, Glycerol, Glycogen, Hydrocortisone, Hydroxybutyrates, Lactates, Liver, Male, Osmolar Concentration, Time Factors, Lactic Acid, 3-Hydroxybutyric Acid, Carbohydrate Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review