CoChat
Sign Up
Cited by 109Muscle metabolism and nutritionClinical Nutrition and GastroenterologyTrauma, Hemostasis, Coagulopathy, Resuscitation

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Albumin and fibrinogen syntheses increase while muscle protein synthesis decreases in head-injured patients

Mansoor, Odile, Cayol, Marc, Gachon, Pierre, Boirie, Yves, Schoeffler, Pierre, Obled, Christiane, Beaufrère, Bernard·1997·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1997.273.5.e898
Open this paper in CoChat — free account

Abstract

The effect of trauma on protein metabolism was investigated in the whole body, muscle, and liver in severely head-injured patients presenting an acute inflammatory response by comparison to fed control subjects receiving a similar diet. Nonoxidative leucine disposal (an index of whole body protein synthesis) and muscle, albumin, and fibrinogen synthesis were determined by means of a primed, continuous infusion ofl-[1-13 C]leucine. Nonoxidative leucine disposal increased by 28% in the patients ( P < 0.02). Fractional muscle protein synthesis rate decreased by 50% ( P < 0.01) after injury. Fractional and absolute fribrinogen synthesis rates were multiplied by two and nine, respectively, after injury ( P< 0.001). Albumin levels were lower in patients (25.2 ± 1.2 g/l, means ± SE) than in controls (33.7 ± 1.2 g/l, P < 0.001). However, fractional albumin synthesis rates were increased by 60% in patients (11.4 ± 1.0%/day) compared with controls (7.3 ± 0.4%/day, P < 0.01). Therefore, 1) head trauma induces opposite and large changes of protein synthesis in muscle and acute-phase hepatic proteins, probably mediated by cytokines, glucocorticoids, and other stress hormones, and 2) in these patients, hypoalbuminemia is not due to a depressed albumin synthesis.

Overview

Integrity signals

Registry

Crossref · 10.1152/ajpendo.1997.273.5.e898

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 9

  1. Baumann P. Q., 1994, Am. J. Physiol., 267, E203
  2. Cooney R., 1994, Am. J. Physiol., 267, E636
  3. Cooney R. N., 1996, Am. J. Physiol., 270, E621
  4. De Feo P., 1992, Am. J. Physiol., 263, E794
  5. Essén P., 1992, Am. J. Physiol., 262, E253
  6. Flakoll P. J., 1995, Am. J. Physiol., 269, E636
  7. Milland J., 1990, Am. J. Physiol., 259, G340
  8. Rennie M. J., 1994, Am. J. Physiol., 266, E298
  9. Zamir O., 1993, Surg. Gynecol. Obstet., 177, 27

Cited by

Sorted by citations

See all 109

Related

See all

Metadata

Authors
Mansoor, O., Cayol, M., Gachon, P., Boirie, Y., Schoeffler, P., Obled, C., & Beaufrère, B.
Affiliations
  • Université Clermont Auvergne (FR)
  • Institut National de la Recherche Agronomique (FR)
  • Laboratoire de Nutrition Humaine, Université d’Auvergne Centre de Recherche en Nutrition Humaine, 63009 Clermont-Ferrand, France
  • Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1997-11-01
Volume
273
Issue
5
Pages
E898-E902
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1997.273.5.e898
OpenAlex
W1962005150
Cited by
109
References
32
Citations by year
2026: 1 · 2023: 1 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
FWCI
1.61
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Keywords
traumatic brain injury, protein synthesis, albumin synthesis, fibrinogen synthesis, muscle protein synthesis, hypoalbuminemia, acute phase response, hepatic protein synthesis, leucine infusion, cytokines, glucocorticoids, stress hormones, trauma-induced inflammation
MeSH terms
Blood Proteins, Calorimetry, Energy Metabolism, Fibrinogen, Craniocerebral Trauma, Humans, Leucine, Liver, Proteins, Reference Values, Serum Albumin, Muscle, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review