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Cited by 123Hormonal Regulation and HypertensionParathyroid Disorders and TreatmentsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells

Mazzocchi, Giuseppina, Aragona, Francesco, Malendowicz, Ludwik K., Nussdorfer, Gastone G.·2001·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.2001.280.2.e209
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Abstract

Parathyroid hormone (PTH) and PTH-related peptide (PTH-RP) are two hypercalcemic hormones that share a common receptor subtype, the PTH/PTH-RP receptor. PTH and PTH-RP concentration dependently enhanced basal aldosterone and cortisol secretion from dispersed human adrenocortical cells, with a maximal effective concentration (∼2-fold increase) of 10−8 M. The secretagogue effect of 10−8 M PTH or PTH-RP was abolished by the PTH/PTH-RP receptor antagonist [Leu 11,d-Trp 12]-PTH-RP-(7–34)-amide (10−6 M). PTH and PTH-RP (10−8 M) raised cAMP and inositol-triphosphate release by dispersed adrenocortical cells, and these effects were blocked by the adenylate cyclase inhibitor SQ-22536 (10−4 M) and the phospholipase C (PLC) inhibitor U-73122 (10−5 M), respectively. SQ-22536 (10−4 M) and U-73122 (10−5 M) partially inhibited aldosterone and cortisol response to 10−8 M PTH and PTH-RP; when added together, they abolished it. Similar results were obtained by using the protein kinase (PK)A and PKC inhibitors H-89 and calphostin C (10−5 M). It is concluded that PTH and PTH-RP exert a sizeable secretagogue action on the human adrenal cortex, probably acting through the PTH/PTH-RP receptor coupled with both adenylate cyclase/PKA- and PLC/PKC-dependent signaling cascades.

Overview

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Crossref · 10.1152/ajpendo.2001.280.2.e209

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Cites

Research works printed but not linked: 3

  1. Mune T, 1993, J Clin Endocrinol Metab, 76, 757
  2. Neri G, 1996, J Clin Endocrinol Metab, 81, 169
  3. Orloff JJ, 1994, Endocr Rev, 15, 40

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Metadata

Authors
Mazzocchi, G., Aragona, F., Malendowicz, L. K., & Nussdorfer, G. G.
Affiliations
  • Section of Anatomy, Department of Human Anatomy and Physiology and
  • University of Padua (IT)
ORCID
Malendowicz, Ludwik K.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2001-02-01
Volume
280
Issue
2
Pages
E209-E213
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.2001.280.2.e209
OpenAlex
W2165014588
Cited by
123
References
28
Citations by year
2026: 2 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 11 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 5 · 2012: 6
FWCI
0.69
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
parathyroid hormone, PTH-related protein, adrenocortical cells, aldosterone secretion, cortisol secretion, steroidogenesis, cAMP signaling, inositol trisphosphate, phospholipase C, protein kinase A, protein kinase C, receptor antagonists, hypercalcemia
MeSH terms
Adenine, Cyclic AMP, Adrenal Cortex, Adrenocorticotropic Hormone, Aldosterone, Enzyme Inhibitors, Estrenes, Humans, Hydrocortisone, Parathyroid Hormone, Peptide Fragments, Proteins, Pyrrolidinones, Inositol 1,4,5-Trisphosphate, Parathyroid Hormone-Related Protein

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