Cited by 123Hormonal Regulation and HypertensionParathyroid Disorders and TreatmentsAdrenal Hormones and Disorders

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PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells

Mazzocchi, Giuseppina, Aragona, Francesco, Malendowicz, Ludwik K., Nussdorfer, Gastone G.·2001·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.2001.280.2.e209

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Abstract

Parathyroid hormone (PTH) and PTH-related peptide (PTH-RP) are two hypercalcemic hormones that share a common receptor subtype, the PTH/PTH-RP receptor. PTH and PTH-RP concentration dependently enhanced basal aldosterone and cortisol secretion from dispersed human adrenocortical cells, with a maximal effective concentration (∼2-fold increase) of 10−8 M. The secretagogue effect of 10−8 M PTH or PTH-RP was abolished by the PTH/PTH-RP receptor antagonist [Leu 11,d-Trp 12]-PTH-RP-(7–34)-amide (10−6 M). PTH and PTH-RP (10−8 M) raised cAMP and inositol-triphosphate release by dispersed adrenocortical cells, and these effects were blocked by the adenylate cyclase inhibitor SQ-22536 (10−4 M) and the phospholipase C (PLC) inhibitor U-73122 (10−5 M), respectively. SQ-22536 (10−4 M) and U-73122 (10−5 M) partially inhibited aldosterone and cortisol response to 10−8 M PTH and PTH-RP; when added together, they abolished it. Similar results were obtained by using the protein kinase (PK)A and PKC inhibitors H-89 and calphostin C (10−5 M). It is concluded that PTH and PTH-RP exert a sizeable secretagogue action on the human adrenal cortex, probably acting through the PTH/PTH-RP receptor coupled with both adenylate cyclase/PKA- and PLC/PKC-dependent signaling cascades.

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Authors: Mazzocchi, G., Aragona, F., Malendowicz, L. K., & Nussdorfer, G. G.
Affiliations: Section of Anatomy, Department of Human Anatomy and Physiology and
University of Padua (IT)
ORCID: Malendowicz, Ludwik K.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2001-02-01
Volume: 280
Issue: 2
Pages: E209-E213
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.2001.280.2.e209
OpenAlex: W2165014588
Cited by: 123
References: 28
Citations by year: 2026: 2 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 11 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 5 · 2012: 6
FWCI: 0.69
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: parathyroid hormone, PTH-related protein, adrenocortical cells, aldosterone secretion, cortisol secretion, steroidogenesis, cAMP signaling, inositol trisphosphate, phospholipase C, protein kinase A, protein kinase C, receptor antagonists, hypercalcemia
MeSH terms: Adenine, Cyclic AMP, Adrenal Cortex, Adrenocorticotropic Hormone, Aldosterone, Enzyme Inhibitors, Estrenes, Humans, Hydrocortisone, Parathyroid Hormone, Peptide Fragments, Proteins, Pyrrolidinones, Inositol 1,4,5-Trisphosphate, Parathyroid Hormone-Related Protein

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PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells

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