The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue.
Open accessAbstract
Recent studies suggest that adipose tissue hypoxia (ATH) may contribute to endocrine dysfunction in adipose tissue of obese mice. In this study, we examined hypoxia's effects on metabolism in adipocytes. We determined the dynamic relationship of ATH and adiposity in ob/ob mice. The interstitial oxygen pressure (Po(2)) was monitored in the epididymal fat pads for ATH. During weight gain from 39.5 to 55.5 g, Po(2) declined from 34.8 to 20.1 mmHg, which are 40-60% lower than those in the lean mice. Insulin receptor-beta (IRbeta) and insulin receptor substrate-1 (IRS-1) were decreased in the adipose tissue of obese mice, and the alteration was observed in 3T3-L1 adipocytes after hypoxia (1% oxygen) treatment. Insulin-induced glucose uptake and Akt Ser(473) phosphorylation was blocked by hypoxia in the adipocytes. This effect of hypoxia exhibited cell type specificity, as it was not observed in L6 myotubes and betaTC6 cells. In response to hypoxia, free fatty acid (FFA) uptake was reduced and lipolysis was increased in 3T3-L1 adipocytes. The molecular mechanism of decreased fatty acid uptake may be related to inhibition of fatty acid transporters (FATP1 and CD36) and transcription factors (PPARgamma and C/EBPalpha) by hypoxia. The hypoxia-induced lipolysis was observed in vivo after femoral arterial clamp. Necrosis and apoptosis were induced by hypoxia in 3T3-L1 adipocytes. These data suggest that ATH may promote FFA release and inhibit glucose uptake in adipocytes by inhibition of the insulin-signaling pathway and induction of cell death.
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“Hypoxia per se decreases insulin signaling and disrupts lipid metabolism in AT”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Yin et al., 2009
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Metadata
- Authors
- Yin, J., Gao, Z., He, Q., Zhou, D., Guo, Z., & Ye, J.
- Affiliations
- Pennington Biomedical Research Center (US)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2009-02
- Volume
- 296
- Issue
- 2
- Pages
- E333-E342
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- PMC
- PMC2645021
- OpenAlex
- W2150350398
- Cited by
- 319
- References
- 59
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 25 · 2023: 13 · 2022: 19 · 2021: 26 · 2020: 21 · 2019: 15 · 2018: 15 · 2017: 28 · 2016: 10 · 2015: 17 · 2014: 19 · 2013: 31 · 2012: 24
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK068036, R01DK068036, DK 68036, P30DK072476)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adipose tissue hypoxia, obesity, insulin signaling, insulin receptor beta, IRS-1, Akt phosphorylation, glucose uptake, fatty acid uptake, lipolysis, free fatty acid release, adipocyte apoptosis, adipocyte necrosis, PPARγ, C/EBPα, FATP1, CD36, ob/ob mice
- MeSH terms
- Adipose Tissue, Animals, Cells, Cultured, Diet, Atherogenic, Gene Expression Regulation, Glucose, Insulin, Male, Mice, Inbred C57BL, Mice, Obese, Obesity, Cell Hypoxia, 3T3-L1 Cells, Glucose Metabolism Disorders, Mice, Rats, Lipid Metabolism Disorders
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