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Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue.
Open accessAbstract
Recent studies suggest that adipose tissue hypoxia (ATH) may contribute to endocrine dysfunction in adipose tissue of obese mice. In this study, we examined hypoxia's effects on metabolism in adipocytes. We determined the dynamic relationship of ATH and adiposity in ob/ob mice. The interstitial oxygen pressure (Po(2)) was monitored in the epididymal fat pads for ATH. During weight gain from 39.5 to 55.5 g, Po(2) declined from 34.8 to 20.1 mmHg, which are 40-60% lower than those in the lean mice. Insulin receptor-beta (IRbeta) and insulin receptor substrate-1 (IRS-1) were decreased in the adipose tissue of obese mice, and the alteration was observed in 3T3-L1 adipocytes after hypoxia (1% oxygen) treatment. Insulin-induced glucose uptake and Akt Ser(473) phosphorylation was blocked by hypoxia in the adipocytes. This effect of hypoxia exhibited cell type specificity, as it was not observed in L6 myotubes and betaTC6 cells. In response to hypoxia, free fatty acid (FFA) uptake was reduced and lipolysis was increased in 3T3-L1 adipocytes. The molecular mechanism of decreased fatty acid uptake may be related to inhibition of fatty acid transporters (FATP1 and CD36) and transcription factors (PPARgamma and C/EBPalpha) by hypoxia. The hypoxia-induced lipolysis was observed in vivo after femoral arterial clamp. Necrosis and apoptosis were induced by hypoxia in 3T3-L1 adipocytes. These data suggest that ATH may promote FFA release and inhibit glucose uptake in adipocytes by inhibition of the insulin-signaling pathway and induction of cell death.
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“Hypoxia per se decreases insulin signaling and disrupts lipid metabolism in AT”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Yin et al., 2009
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Cites
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Bastard, J., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J., & Fève, B. (2006) · PubMed · Cited by 2,090
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728
Helmlinger, G., Yuan, F., Dellian, M., & Jain, R. K. (1997) · Nature Medicine · doi:10.1038/nm0297-177 · Cited by 1,651
Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diab.43.11.1271 · Cited by 1,353
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes · doi:10.2337/db06-0911 · Cited by 1,257
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,220
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
Strissel, K. J., Stancheva, Z., Miyoshi, H., Perfield, J. W., DeFuria, J., Jick, Z., Greenberg, A. S., & Obin, M. S. (2007) · Diabetes · doi:10.2337/db07-0767 · Cited by 1,007
Signal transduction to hypoxia-inducible factor 1
Semenza, G. L. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01168-1 · Cited by 860
Ye, J., Gao, Z., Yin, J., & He, Q. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2007 · Cited by 840
Self-citationHotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis: Figure 1
Greijer, A. E., & van der Wall, E. (2004) · Journal of Clinical Pathology · doi:10.1136/jcp.2003.015032 · Cited by 798
The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
Goossens, G. H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.010 · Cited by 591
Rausch, M. E., Weisberg, S., Vardhana, P., & Tortoriello, D. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803744 · Cited by 585
Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity
Kim, F., Pham, M., Luttrell, I., Bannerman, D. D., Tupper, J., Thaler, J., Hawn, T. R., Raines, E. W., & Schwartz, M. W. (2007) · Circulation Research · doi:10.1161/circresaha.106.142851 · Cited by 584
Salans, L. B., Knittle, J. L., & Hirsch, J. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105705 · Cited by 581
Stephens, J. M., Lee, J., & Pilch, P. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.971 · Cited by 553
Lee, J. Y., Ye, J., Gao, Z., Youn, H. S., Lee, W. H., Zhao, L., Sizemore, N., & Hwang, D. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305213200 · Cited by 524
Self-citationFree fatty acids and insulin resistance
Delarue, J., & Magnan, C. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328042ba90 · Cited by 478
Inhibition of PPARγ2 Gene Expression by the HIF-1-Regulated Gene DEC1/Stra13
Yun, Z., Maecker, H. L., Johnson, R. S., & Giaccia, A. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00131-4 · Cited by 460
Berberine improves glucose metabolism through induction of glycolysis
Yin, J., Gao, Z., Liu, D., Liu, Z., & Ye, J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00211.2007 · Cited by 418
Self-citationBar, R. S., Görden, P., Roth, J., Kahn, C. R., & MEYTS, P. D. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108565 · Cited by 413
Wang, B., Wood, I. S., & Trayhurn, P. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0301-8 · Cited by 392
The Physiology of Obese-Hyperglycemic Mice [ob/obMice]
Lindström, P. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.117 · Cited by 372
Gao, Z., Zhang, X., Zuberi, A. R., Hwang, D. H., Quon, M. J., Lefevre, M., & Ye, J. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0383 · Cited by 335
Self-citationRole of macrophage tissue infiltration in metabolic diseases
Bouloumié, A., Curat, C. A., Sengenès, C., Lolmède, K., Miranville, A., & Busse, R. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000172571.41149.52 · Cited by 268
Kaestner, K. H., Christy, R. J., & Lane, M. D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.251 · Cited by 268
Chen, B., Lam, K. S. L., Wang, Y., Wu, D., Lam, M. C., Shen, J., Wong, L., Hoo, R. L. C., Zhang, J., & Xu, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.004 · Cited by 238
Relation between Age of Onset of Obesity and Size and Number of Adipose Cells
Brook, C. G. D., Lloyd, J. K., & Wolf, O. (1972) · BMJ · doi:10.1136/bmj.2.5804.25 · Cited by 214
Shi, J., & Kandror, K. V. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.004 · Cited by 213
The effect of insulin upon glucose metabolism by adipose cells of different size
Salans, L. B., & Dougherty, J. W. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106623 · Cited by 181
Summers, L. K. M., Samra, J. S., Humphreys, S. M., Morris, R. J., & Frayn, K. N. (1996) · Clinical Science · doi:10.1042/cs0910679 · Cited by 167
Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4
Lobo, S., Wiczer, B. M., Smith, A. J., Hall, A. M., & Bernlohr, D. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600441-jlr200 · Cited by 151
Wood, I. S., Wang, B., Lorente‐Cebrián, S., & Trayhurn, P. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.032 · Cited by 149
Liao, W., Nguyen, M. T., Yoshizaki, T., Favelyukis, S., Patsouris, D., Imamura, T., Verma, I. M., & Olefsky, J. M. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00695.2006 · Cited by 149
Effects of Age and Obesity on Insulin Binding to Isolated Adipocytes1212
Olefsky, J. M., & Reaven, G. M. (1975) · Endocrinology · doi:10.1210/endo-96-6-1486 · Cited by 144
Gao, Z., He, Q., Peng, B., Chiao, P. J., & Ye, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507784200 · Cited by 141
Self-citationLeptin Stimulates Ischemia-Induced Retinal Neovascularization
Suganami, E., Takagi, H., Ohashi, H., Suzuma, K., Suzuma, I., Oh, H., Watanabe, D., Ojima, T., Suganami, T., Fujio, Y., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2443 · Cited by 141
Shohet, R. V., & Garcia, J. A. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0279-x · Cited by 129
Bashan, N., Burdett, E., Hundal, H. S., & Klip, A. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.3.c682 · Cited by 121
Role of Insulin in the Pathogenesis of Free Fatty Acid-Induced Insulin Resistance in Skeletal Muscle
Ye, J. (2007) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153007780059423 · Cited by 106
Self-citationZhou, S., Lechpammer, S., Greenberger, J. S., & Glowacki, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412953200 · Cited by 96
Obesity, essential hypertension and renin–angiotensin system
Segura, J., & Ruilope, L. M. (2007) · Public Health Nutrition · doi:10.1017/s136898000700064x · Cited by 95
Hypoxia inhibits adipocyte differentiation in a HDAC-independent manner
Kim, K. H., Song, M. J., Chung, J., Park, H., & Kim, J. B. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.023 · Cited by 83
Insulin resistance in adipocytes of obese women: Effects of body fat distribution and race
Dowling, H. J., Fried, S. K., & Pi-Sunyer, X. (1995) · Metabolism · doi:10.1016/0026-0495(95)90094-2 · Cited by 77
Adipocyte blood flow is decreased in obese Zucker rats
West, D. B., Prinz, W. A., Francendese, A. A., & Greenwood, M. R. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.253.2.r228 · Cited by 65
Lentiviral Short Hairpin Ribonucleic Acid-Mediated Knockdown of GLUT4 in 3T3-L1 Adipocytes
Liao, W., Nguyen, M. T., Imamura, T., Singer, O., Verma, I. M., & Olefsky, J. M. (2006) · Endocrinology · doi:10.1210/en.2005-1638 · Cited by 60
Gap junctional intercellular communication in hypoxia–ischemia-induced neuronal injury
Talhouk, R., Zeinieh, M. P., Mikati, M. A., & El-Sabban, M. E. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.001 · Cited by 47
Ko, S., Ryu, G. R., Kim, S., Ahn, Y., Yoon, K., Kaneto, H., Ha, H., Kim, Y. S., & Song, K. (2008) · Transplantation · doi:10.1097/tp.0b013e31816168f9 · Cited by 42
Derave, W., & Hespel, P. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.255ad.x · Cited by 39
Park, S.-K., Haase, V. H., & Johnson, R. S. (2007) · International Journal of Oncology · doi:10.3892/ijo.30.2.341 · Cited by 32
Idstrom, J. P., Rennie, M. J., Scherstén, T., & Bylund‐Fellenius, A. (1986) · Biochemical Journal · doi:10.1042/bj2330131 · Cited by 29
Is oxygen a key factor in the lipodystrophy phenotype?
Gentil, C., Jan, S. L., Philippe, J., Leibowitch, J., Sonigo, P., Germain, S., & Piétri‐Rouxel, F. (2006) · Lipids in Health and Disease · doi:10.1186/1476-511x-5-27 · Cited by 19
Metabolic syndrome, cardiovascular disease and type-2 diabetes.
Bano, K. A., & Batool, A. (2007) · PubMed · Cited by 18
Insulin resistance: central and peripheral mechanisms. The 2007 Stock Conference Report
Ye, J., & Kraegen, T. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00402.x · Cited by 13
Self-citationMuscle Type‐Dependent Responses to Insulin in Intramyocellular Triglyceride Turnover in Obese Rats
Guo, Z., & Zhou, L. (2005) · Obesity Research · doi:10.1038/oby.2005.258 · Cited by 9
Self-citationFreychet, P., Forgue, E., MARCHAND‐BRUSTEL, Y. L., & Laudat, M. H. (1976) · PubMed · Cited by 2
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Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
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Metadata
- Authors
- Yin, J., Gao, Z., He, Q., Zhou, D., Guo, Z., & Ye, J.
- Affiliations
- Pennington Biomedical Research Center (US)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2009-02
- Volume
- 296
- Issue
- 2
- Pages
- E333-E342
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- PMC
- PMC2645021
- OpenAlex
- W2150350398
- Cited by
- 319
- References
- 59
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 25 · 2023: 13 · 2022: 19 · 2021: 26 · 2020: 21 · 2019: 15 · 2018: 15 · 2017: 28 · 2016: 10 · 2015: 17 · 2014: 19 · 2013: 31 · 2012: 24
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK068036, R01DK068036, DK 68036, P30DK072476)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adipose tissue hypoxia, obesity, insulin signaling, insulin receptor beta, IRS-1, Akt phosphorylation, glucose uptake, fatty acid uptake, lipolysis, free fatty acid release, adipocyte apoptosis, adipocyte necrosis, PPARγ, C/EBPα, FATP1, CD36, ob/ob mice
- MeSH terms
- Adipose Tissue, Animals, Cells, Cultured, Diet, Atherogenic, Gene Expression Regulation, Glucose, Insulin, Male, Mice, Inbred C57BL, Mice, Obese, Obesity, Cell Hypoxia, 3T3-L1 Cells, Glucose Metabolism Disorders, Mice, Rats, Lipid Metabolism Disorders
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