The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium
Open accessAbstract
SOX transcription factors have the capacity to modulate stem/progenitor cell proliferation and differentiation in a dose-dependent manner. SOX9 is expressed in the small intestine epithelial stem cell zone. Therefore, we hypothesized that differential levels of SOX9 may exist, influencing proliferation and/or differentiation of the small intestine epithelium. Sox9 expression levels in the small intestine were investigated using a Sox9 enhanced green fluorescent protein ( Sox9 EGFP) transgenic mouse. Sox9 EGFP levels correlate with endogenous SOX9 levels, which are expressed at two steady-state levels, termed Sox9 EGFPLO and Sox9 EGFPHI. Crypt-based columnar cells are Sox9 EGFPLO and demonstrate enriched expression of the stem cell marker, Lgr5. Sox9 EGFPHI cells express chromogranin A and substance P but do not express Ki67 and neurogenin3, indicating that Sox9 EGFPHI cells are postmitotic enteroendocrine cells. Overexpression of SOX9 in a crypt cell line stopped proliferation and induced morphological changes. These data support a bimodal role for SOX9 in the intestinal epithelium, where low SOX9 expression supports proliferative capacity, and high SOX9 expression suppresses proliferation.
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Citations
Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Cited by
Furuyama, K., Kawaguchi, Y., Akiyama, H., Horiguchi, M., Kodama, S., Kuhara, T., Hosokawa, S., Elbahrawy, A., Soeda, T., Koizumi, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.722 · Cited by 834
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity
Yan, K. S., Gevaert, O., Zheng, G. X. Y., Anchang, B., Probert, C. S., Larkin, K. A., Davies, P. S., Cheng, Z.-F., Kaddis, J. S., Han, A., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.06.014 · Cited by 361
Rangan, P., Choi, I., Wei, M., Navarrete, G., Guen, E., Brandhorst, S., Enyati, N., Pasia, G., Maesincee, D., Ocon, V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.019 · Cited by 312
“Lgr5 is an established marker for crypt base columnar (CBC) stem cells (Barker, 2014), whereas Sox9 is expressed in CBCs but also in enteroendocrine cells (Formeister et al., 2009).”
BackgroundThe intestinal epithelium tuft cells: specification and function
Gerbe, F., Legraverend, C., & Jay, P. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0984-7 · Cited by 295
DNA damage-induced type I interferon promotes senescence and inhibits stem cell function
Yu, Q., Katlinskaya, Y. V., Carbone, C. J., Zhao, B., Katlinski, K. V., Zheng, H., Guha, M., Li, N., Chen, Q., Yang, T., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.069 · Cited by 260
Metadata
- Authors
- Formeister, E. J., Sionas, A. L., Lorance, D. K., Barkley, C. L., Lee, G. H., & Magness, S. T.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2009-05
- Volume
- 296
- Issue
- 5
- Pages
- G1108-G1118
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2171560127
- Cited by
- 232
- References
- 2
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium. https://app.cochat.ai/papers/10.1152/ajpgi.00004.2009
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- Formeister, E. J., Sionas, A. L., Lorance, D. K., Barkley, C. L., Lee, G. H., & Magness, S. T. (2009). Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00004.2009
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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