The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
The intestinal epithelium tuft cells: specification and function
Open accessAbstract
The intestinal epithelium, composed of at least seven differentiated cell types, represents an extraordinary model to understand the details of multi-lineage differentiation, a question that is highly relevant in developmental biology as well as for clinical applications. This review focuses on intestinal epithelial tuft cells that have been acknowledged as a separate entity for more than 60 years but whose function remains a mystery. We discuss what is currently known about the molecular basis of tuft cell fate and differentiation and why elucidating tuft cell function has been so difficult. Finally, we summarize the current hypotheses on their potential involvement in diseases of the gastro-intestinal tract.
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Cites
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“T1R1/T1R3 Apical side of the cell [38] Secretory granules of Paneth cell, brush border of enterocytes and enteroendocrine cells [44, 47, 49]”
BackgroundRequirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine
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Cited by
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit
von Moltke, J., Ji, M., Liang, H.-E., & Locksley, R. M. (2016) · Nature · doi:10.1038/nature16161 · Cited by 1,230
Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier
Martens, E. C., Neumann, M., & Desai, M. S. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0036-x · Cited by 711
Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium
Gribble, F. M., & Reimann, F. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105439 · Cited by 683
Gut Microbiota: An Integral Moderator in Health and Disease
Feng, Q., Chen, W.-D., & Wang, Y.-D. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00151 · Cited by 407
Organoids in immunological research
Bar-Ephraim, Y. E., Kretzschmar, K., & Clevers, H. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0248-y · Cited by 361
Metadata
- Authors
- Gerbe, F., Legraverend, C., & Jay, P.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2012-04-19
- Volume
- 69
- Issue
- 17
- Pages
- 2907-2917
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W2050306701
- Cited by
- 295
- References
- 68
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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