The DOI matches its Crossref record; 61 of the 62 references it cites were found in a registry or an index.
Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis
Abstract
Enteroendocrine cells act as sensory transducers, releasing 5-HT and numerous peptides that are involved in regulating motility, secretion, and gut sensation. The action of mucosal 5-HT is terminated by a 5-HT reuptake transporter (SERT). In this study, we examined the hypothesis that ileitis leads to changes in enteroendocrine cell populations and mucosal 5-HT availability. Ileitis was induced in guinea pigs by intraluminal injection of 2,4,6-trinitrobenzenesulfonic acid and experiments were conducted 3, 7, and 14 days after treatment. The number of somatostatin, neurotensin, and 5-HT-immunoreactive cells increased at 3 and 7 days of ileitis, respectively, whereas no significant changes in the numbers of cholecystokinin, glucagon-like peptide-2, glucose-dependent insulinotropic peptide, and peptide YY-immunoreactive cells were observed. Chemical stimulation of the inflamed mucosa with sodium deoxycholic acid significantly increased 5-HT release compared with basal release. Mechanical stimulation of the mucosa potentiated the effect of the chemical stimuli at day 7. Epithelial SERT immunoreactivity was significantly reduced during the time course of inflammation. Thus changes in enteroendocrine cell populations and 5-HT availability could contribute to the altered motility and secretion associated with intestinal inflammation by disrupting mucosal signaling to enteric nerves involved in peristaltic and secretory reflexes.
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“As afferent nerves are not exposed to the luminal side of the intestine, under normal circumstances sensory neurons are indirectly activated by stimuli in the intestinal lumen via paracrine signaling, which is mediated by compounds such as serotonin, cholecystokinin, histamine, secretin, somatostatin, melatonin, uroguanylin, and corticotrophin-releasing factor, all of which can be released from ne”
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Metadata
- Authors
- O'Hara, J. R., Ho, W., Linden, D. R., Mawe, G. M., & Sharkey, K. A.
- Affiliations
- University of Calgary (CA)
- University of Vermont (US)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2004-11
- Volume
- 287
- Issue
- 5
- Pages
- G998-G1007
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2112881025
- Cited by
- 139
- References
- 62
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 7
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK62267, R01DK062267, F32DK060382, F32-DK-60382)
- National Institute of Neurological Disorders and Stroke (NS 26995)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- enteroendocrine cells, serotonin, intestinal inflammation, somatostatin, neurotensin, cholecystokinin, glucagon-like peptide-2, glucose-dependent insulinotropic polypeptide, peptide YY, mechanical stimulation, enteric nerves, intestinal motility
- MeSH terms
- Animals, Biological Availability, Cell Count, Guinea Pigs, Ileitis, Intestinal Mucosa, Male, Membrane Glycoproteins, Nerve Tissue Proteins, Serotonin, Trinitrobenzenesulfonic Acid, Enteroendocrine Cells, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins
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