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Cited by 511Gastrointestinal motility and disordersInflammatory Bowel DiseaseNeuropeptides and Animal Physiology

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The immunomodulation of enteric neuromuscular function: Implications for motility and inflammatory disorders

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Collins, SM·1996·Gastroenterology
DOI 10.1016/s0016-5085(96)70034-3
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Abstract

Gastrointestinal motility and sensory perception are altered in a variety of mucosal inflammatory conditions of the gut, ranging from peptic esophagitis to ulcerative colitis. Studies in animal models now clearly indicate a causal relationship between the presence of mucosal inflammation and altered sensory-motor function. In many instances, these changes occur in the absence of any discernible encroachment of the deeper neuromuscular layers by the inflammatory infiltrate, which remains largely within the lamina propria. Accordingly, attention has focused on local sources of mediators, and recent studies indicate that smooth muscle cells and enteroglia are sources of and targets for cytokines such as interleukin 1 beta and interleukin 6. In several instances, neuromuscular dysfunction persists after mucosal inflammation has subsided; this state may be maintained by locally produced mediators. Studies also show the ability of enteric muscle to modulate lymphocyte function via major histocompatibility complex II-restricted antigen presentation. Clinical observation and experimental data also suggest that nerves modulate intestinal inflammation via local release of proinflammatory neuropeptides (substance P) and via the activation of extensive circuits that may involve the brain. Taken together, these findings provide plausible explanations for a variety of clinical scenarios ranging from inflammatory bowel disease to pseudo-obstruction syndromes and subgroups of functional bowel disorders.

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  • Cytokines may influence epithelial cells, smooth muscle and enteric nerves, which supports a possible role in generating IBS symptoms.

    “The possible role of cytokines in IBS symptom generation has found support in studies showing that cytokines influence epithelial cells, smooth muscle and enteric nerves. 22”

    From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [22]

  • The effects of inflammation on sensorimotor enteric function have been demonstrated in inflammatory bowel diseases, where patients suffer from abnormal intestinal motor function and enhanced sensory perception, even when inflammation is restricted to the mucosa.

    “The effects of inflammation on sensorimotor enteric function have been demonstrated in IBDs, where patients suffer from abnormal intestinal motor function and enhanced sensory perception, even when inflammation is restricted to the mucosa (44, 143).”

    From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [44]

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  60. Bjorck S, Dahlstrom A, Johansson L, Ahlman H. Treatment of Crohn's and Colitis Foundation of Canada. the mucosa with local anaesthetics in ulcerative colitis. Agents The author thanks Gil Castro for his inspiration and encouragement Actions 1992;10:C61-C72. in this field and numerous colleagues, postdoctoral fellows, and stu- 170.
  61. Ottaway CA. Neuroimmunomodulation in the intestinal mucosa. dents at McMaster University, who have contributed to much of the Gastroenterol Clin North Am 1991;20:511-529. work reviewed in this paper. / 5e14$$0043 11-20-96 08:35:07 WBS-Gastro

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Metadata

Authors
Collins, S.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1996-12
Volume
111
Issue
6
Pages
1683-1699
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/s0016-5085(96)70034-3
OpenAlex
W1970757039
Cited by
511
References
25
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 8 · 2016: 12 · 2015: 11 · 2014: 12 · 2013: 18 · 2012: 10
FWCI
4.41
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
enteric nervous system, gastrointestinal motility, mucosal inflammation, immunomodulation, smooth muscle cells, cytokines, IL-1β, interleukin-6, MHC class II antigen presentation, substance P, neuropeptides, inflammatory bowel disease, pseudo-obstruction, functional bowel disorders, sensory-motor dysfunction
MeSH terms
Adjuvants, Immunologic, Animals, Digestive System, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Inflammation

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