The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning
Abstract
Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with liver surgery under total vascular exclusion or after liver transplantation. The pathophysiology of hepatic ischemia-reperfusion includes a number of mechanisms that contribute to various degrees in the overall injury. Some of the topics discussed in this review include cellular mechanisms of injury, formation of pro- and anti-inflammatory mediators, expression of adhesion molecules, and the role of oxidant stress during the inflammatory response. Furthermore, the roles of nitric oxide in preventing microcirculatory disturbances and as a substrate for peroxynitrite formation are reviewed. In addition, emerging mechanisms of protection by ischemic preconditioning are discussed. On the basis of current knowledge, preconditioning or pharmacological interventions that mimic these effects have the greatest potential to improve clinical outcome in liver surgery involving ischemic stress and reperfusion.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
Tissue Destruction by Neutrophils
(1989) · New England Journal of Medicine · doi:10.1056/nejm198908033210513 · Cited by 3,631
Apoptosis, oncosis, and necrosis. An overview of cell death.
Majno, G., & Joris, I. (1995) · PubMed · Cited by 3,306
NEUTROPHIL INFILTRATION AS AN IMPORTANT FACTOR IN LIVER ISCHEMIA AND REPERFUSION INJURY
TOLEDO-PEREYRA, L. H., RODRIGUEZ, F. J., & CEJALVO, D. (1993) · Transplantation · doi:10.1097/00007890-199306000-00011 · Cited by 894
The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion
Granger, D. N., & Kubes, P. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.5.662 · Cited by 849
Colletti, L. M., Remick, D. G., Burtch, G. D., Kunkel, S. L., Strieter, R. M., & Campbell, D. A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114656 · Cited by 817 · cited 2×
“Because of the central role of TNF- in promoting the inflammatory response at different levels, suppressing the formation of TNF- or neutralizing it with antibodies proved to be highly effective in attenuating acute postischemic inflammation and injury (23, 25, 32).”
BackgroundOxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide
Squadrito, G. L., & Pryor, W. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00095-1 · Cited by 795
Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo
Jaeschke, H., Farhood, A., & Smith, C. W. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.15.2253850 · Cited by 730
Self-citationNeutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver
Jaeschke, H., & Farhood, A. (1991) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1991.260.3.g355 · Cited by 661
Self-citationLeist, M., Gantner, F., Bohlinger, I., Germann, P. G., Tiegs, G., & Wendel, A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.4.1778 · Cited by 492
Cited by
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
Self-citationThe nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
Tsung, A., Sahai, R., Tanaka, H., Nakao, A., Fink, M. P., Lotze, M. T., Yang, H., Li, J., Tracey, K. J., Geller, D. A., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042614 · Cited by 1,113
Jaeschke, H., McGill, M. R., & Ramachandran, A. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.602688 · Cited by 964
Self-citationReactive oxygen species in tumor metastasis
Nishikawa, M. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.031 · Cited by 398
Metadata
- Authors
- Jaeschke, H.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2003-01-01
- Volume
- 284
- Issue
- 1
- Pages
- G15-G26
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2158501840
- Cited by
- 852
- References
- 144
- FWCI
- 47.01
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. https://app.cochat.ai/papers/10.1152/ajpgi.00342.2002
- The paper
- Jaeschke, H. (2003). Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00342.2002
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
