Recent Events in Alcoholic Liver Disease V. Effects of ethanol on liver regeneration
Abstract
Liver regeneration is necessary to recover from alcoholic liver injury. Herein, we review evidence that ethanol interferes with liver regeneration. Briefly, alcoholic fatty livers demonstrate increased rates of hepatocyte death. The latter provides a regenerative stimulus. However, unlike mature hepatocytes in healthy adult livers, most surviving mature hepatocytes in alcoholic fatty livers cannot replicate. Therefore, less mature cells (progenitors) must differentiate to replace dead hepatocytes. Little is known about the general mechanisms that modulate the differentiation of liver progenitors in adults. Delineation of these mechanisms and clarification of how ethanol influences them might suggest new therapies for alcoholic liver disease.
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Chronic and excessive alcohol intake is known to cause liver injury from mild steatosis (AFLD) to more advanced liver disease such as ASH, fibrosis/cirrhosis, hepatic cancer, liver failure, and death.
“Chronic and excessive alcohol intake is known to cause liver injury from mild steatosis (simple fat accumulation in so-called alcoholic fatty liver disease, AFLD) to more advanced liver disease such as inflammation (alcoholic steatohepatitis, ASH), fibrosis/cirrhosis, hepatic cancer, liver failure, and death203–213.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [207]
Cites
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828 · see citing works
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588 · see citing works
Cell fusion is the principal source of bone-marrow-derived hepatocytes
Wang, X., Willenbring, H., Akkari, Y. M. N., Torimaru, Y., Foster, M., Al-Dhalimy, M., Lagasse, E., Finegold, M. J., Olson, S. B., & Grompe, M. (2003) · Nature · doi:10.1038/nature01531 · Cited by 1,569 · see citing works
Yamada, Y., Kirillova, I., Peschon, J. J., & Fausto, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1441 · Cited by 944 · see citing works
Liver regeneration: molecular mechanisms of growth control
Michalopoulos, G. K. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.2.2404819 · Cited by 897 · see citing works
Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species
Lee, A. C., Fenster, B. E., Ito, H., Takeda, K., Bae, N. S., Hirai, T., Yu, Z.-X., Ferrans, V. J., Howard, B. H., & Finkel, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7936 · Cited by 691 · see citing works
c-Jun is essential for normal mouse development and hepatogenesis
Hilberg, F., Aguzzi, A., Howells, N., & Wagner, E. F. (1993) · Nature · doi:10.1038/365179a0 · Cited by 539 · see citing works
Regulatory phases of early liver development: paradigms of organogenesis
Zaret, K. S. (2002) · Nature Reviews Genetics · doi:10.1038/nrg837 · Cited by 507 · see citing works
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
Iimuro, Y., Nishiura, T., Hellerbrand, C., Behrns, K. E., Schoonhoven, R., Grisham, J. W., & Brenner, D. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci483 · Cited by 447 · see citing works
Roskams, T., Yang, S. Q., Koteish, A., Durnez, A., DeVos, R., Huang, X., Achten, R., Verslype, C., & Diehl, A. M. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63489-x · Cited by 447 · see citing works
Self-citationThe origin and liver repopulating capacity of murine oval cells
Wang, X., Foster, M., Al-Dhalimy, M., Lagasse, E., Finegold, M., & Grompe, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734199100 · Cited by 410 · see citing works
Current concepts in the pathogenesis of alcoholic liver injury
Tsukamoto, H., & Lu, S. C.-L. (2001) · The FASEB Journal · doi:10.1096/fj.00-0650rev · Cited by 381 · see citing works
Plasticity of Bone Marrow–Derived Stem Cells
Grove, J. E., Bruscia, E. M., & Krause, D. S. (2004) · Stem Cells · doi:10.1634/stemcells.22-4-487 · Cited by 368 · see citing works
Impaired liver regeneration in inducible nitric oxide synthasedeficient mice
Rai, R. M., Lee, F.-Y. J., Rosen, A., Yang, S. Q., Lin, H. Z., Koteish, A. A., Liew, F. Y., Zaragoza, C., Lowenstein, C. J., & Diehl, A. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13829 · Cited by 242 · see citing works
Self-citationSelective Activation of p38 MAPK Cascade and Mitotic Arrest Caused by Low Level Oxidative Stress
Kurata, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000308200 · Cited by 199 · see citing works
Lee, J. F. Y., Li, Y., Zhu, H., Yang, S., Lin, H. Z., Trush, M. A., & Diehl, A. M. (1999) · Hepatology · doi:10.1002/hep.510290320 · Cited by 155 · see citing works
Self-citationGordon, G. J., Coleman, W. B., & Grisham, J. W. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64591-9 · Cited by 140 · see citing works
Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury
Diehl, A. M., Yin, M., Fleckenstein, J., Yang, S. Q., Lin, H., Brenner, D. A., Westwick, J. K., Bagby, G. J., & Nelson, S. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.4.g552 · Cited by 128 · see citing works
Self-citationCyclin D1 Represses STAT3 Activation through a Cdk4-independent Mechanism
Bienvenu, F., Gascan, H., & Coqueret, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100795200 · Cited by 115 · see citing works
In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway
Ledda-Columbano, G. M., Curto, M., Piga, R., Zedda, A. I., Menegazzi, M., Sartori, C., Shinozuka, H., Bluethmann, H., Poli, V, Ciliberto, G., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1202018 · Cited by 96 · see citing works
Devi, B. G., Henderson, G. I., Frosto, T. A., & Schenker, S. (1993) · Hepatology · doi:10.1002/hep.1840180325 · Cited by 96 · see citing works
Changes in glutathione homeostasis during liver regeneration in the rat
Huang, Z., Li, H., Cai, J., Kuhlenkamp, J., Kaplowitz, N., & Lu, S. C.-L. (1998) · Hepatology · doi:10.1002/hep.510270123 · Cited by 92 · see citing works
Overview of Recent Experimental Studies on Liver Stem Cells
Thorgeirsson, S. S., & Grisham, J. W. (2003) · Seminars in Liver Disease · doi:10.1055/s-2004-815559 · Cited by 67 · see citing works
Koteish, A. A., Yang, S., Lin, H., Huang, J., & Diehl, A. M. (2002) · PubMed · doi:10.1097/01.alc.0000036923.77613.59 · Cited by 66 · see citing works
Self-citationKoteish, A. A., Yang, S., Lin, H., Huang, J., & Diehl, A. M. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02475.x · Cited by 64 · see citing works
Self-citationPancreatic–hepatic switches in vivo
Grompe, M. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00336-2 · Cited by 51 · see citing works
Superoxides Relay Ras Protein's Oncogenic Message
Pennisi, E. (1997) · Science · doi:10.1126/science.275.5306.1567 · Cited by 46 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Role of Oxidative Stress and Antioxidants in Liver Diseases
Li, S., Tan, H., Wang, N., Zhang, Z.-J., Lao, L., Wong, C.-W., & Feng, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125942 · Cited by 1,837 · see citing works
Alcoholic liver disease: mechanisms of injury and targeted treatment
Louvet, A., & Mathurin, P. (2015) · Nature Reviews Gastroenterology &Hepatology · doi:10.1038/nrgastro.2015.35 · Cited by 820 · see citing works
Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
The Effect of Inflammatory Cytokines in Alcoholic Liver Disease
Kawaratani, H., Tsujimoto, T., Douhara, A., Takaya, H., Moriya, K., Namisaki, T., Noguchi, R., Yoshiji, H., Fujimoto, M., & Fukui, H. (2013) · Mediators of Inflammation · doi:10.1155/2013/495156 · Cited by 258 · see citing works
Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study
Katoonizadeh, A., Laleman, W., Verslype, C., Wilmer, A. P., Maleux, G. A., Roskams, T., & Nevens, F. (2010) · Gut · doi:10.1136/gut.2009.189639 · Cited by 252 · see citing works
Spahr, L., Lambert, J., Rubbia‐Brandt, L., Chalandon, Y., Frossard, J., Giostra, E., & Hadengue, A. (2008) · Hepatology · doi:10.1002/hep.22317 · Cited by 221 · see citing works
Timchenko, N. A. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.01.005 · Cited by 220 · see citing works
The roles of innate immune cells in liver injury and regeneration.
Dong, Z., Wei, H., Sun, R., & Tian, Z. (2007) · PubMed · Cited by 167 · see citing works
Jung, Y., Brown, K. D., Witek, R. P., Omenetti, A., Yang, L., Vandongen, M., Milton, R. J., Hines, I. N., Rippe, R. A., Spahr, L., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.022 · Cited by 167 · see citing works
Self-citationMcKillop, I. H., & Schrum, L. W. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.04.004 · Cited by 151 · see citing works
Yip, W. W., & Burt, A. D. (2006) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2006.11.002 · Cited by 150 · see citing works
Oxidative Stress, Genomic Integrity, and Liver Diseases
Sadasivam, N., Kim, Y., Radhakrishnan, K., & Kim, D. (2022) · Molecules · doi:10.3390/molecules27103159 · Cited by 129 · see citing works
Ethanol‐Induced Liver Injury: Potential Roles for Egr‐1
Pritchard, M. T., & Nagy, L. E. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189286.81943.51 · Cited by 88 · see citing works
Hepatic cell proliferation plays a pivotal role in the prognosis of alcoholic hepatitis
Lanthier, N., Rubbia‐Brandt, L., Lin-Marq, N., Clément, S., Frossard, J., Goossens, N., Hadengue, A., & Spahr, L. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.003 · Cited by 73 · see citing works
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review)
Kawaratani, H., Moriya, K., Namisaki, T., Uejima, M., Kitade, M., Takeda, K., Okura, Y., Kaji, K., Takaya, H., Nishimura, N., et al. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3015 · Cited by 65 · see citing works
Zhong, Z., & Lemasters, J. J. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13877 · Cited by 55 · see citing works
Physiological potential of cytokines and liver damages
Mannaa, F., & Abdel-Wahhab, K. G. (2016) · Hepatoma Research · doi:10.20517/2394-5079.2015.58 · Cited by 42 · see citing works
Faloppi, L., Scartozzi, M., Maccaroni, E., Paolo, M. D. P., Berardi, R., Prete, M. D., & Cascinu, S. (2010) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2010.08.001 · Cited by 49 · see citing works
New concepts in the pathogenesis of alcoholic liver disease
Albano, E. (2008) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2.6.749 · Cited by 41 · see citing works
Liver biopsy in alcoholic and non-alcoholic steatohepatitis patients
TINIAKOS, D. G. (2009) · Gastroentérologie Clinique et Biologique · doi:10.1016/j.gcb.2009.05.009 · Cited by 39 · see citing works
Ronis, M. J. J., Hennings, L. J., Stewart, B. J., Basnakian, A. G., Apostolov, E. O., Albano, E., Badger, T. M., & Petersen, D. R. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00145.2010 · Cited by 38 · see citing works
Innate immune reactivity of the liver in rats fed a cholinedeficient L-amino-acid-defined diet
Kawaratani, H., Tsujimoto, T., Kitazawa, T., Kitade, M., Yoshiji, H., Uemura, M., & Fukui, H. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6655 · Cited by 38 · see citing works
Chavez, P. R. G., Lian, F., Chung, J., Liu, C., de Paiva, S. A. R., Seitz, H. K., & Wang, X. (2011) · Journal of Nutrition · doi:10.3945/jn.110.136531 · Cited by 30 · see citing works
Dumitru, A., Matei, E., Cozaru, G., Chisoi, A., Alexandrescu, L., Popescu, R., Butcaru, M. P., Dumitru, E., Rugină, S., & Tocia, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052472 · Cited by 27 · see citing works
Hepatoprotective effect ofGeranium schiedeanumagainst ethanol toxicity during liver regeneration
Madrigal‐Santillán, E. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i25.7718 · Cited by 25 · see citing works
Han, J., Lee, C., Hur, J., & Jung, Y. (2022) · Cells · doi:10.3390/cells12010022 · Cited by 21 · see citing works
Willner, I. R., & Reuben, A. (2005) · Current Opinion in Internal Medicine · doi:10.1097/01.mog.0000160044.87933.87 · Cited by 21 · see citing works
Park, H., Lee, E., Kim, Y., Jung, H. Y., Kim, K.-M., & Kwon, O. (2021) · Antioxidants · doi:10.3390/antiox10030459 · Cited by 19 · see citing works
Inflammation and MMPs in alcohol-induced liver diseases and protective action of antioxidants.
Banerjee, P., Jana, S., Chakraborty, S., & Swarnakar, S. (2013) · PubMed · Cited by 19 · see citing works
Mitchell, M. C., & Szabó, G. (2017) · doi:10.1002/9781119251316.ch26 · Cited by 19 · see citing works
Calmodulin Controls Liver Proliferation via Interactions with C/EBPβ-LAP and C/EBPβ-LIP
Orellana, D. I., Liu, X., Wang, G.-L., Jin, J., Iakova, P. A., & Timchenko, N. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.129825 · Cited by 18 · see citing works
Kuttippurathu, L., Juskeviciute, E., Dippold, R. P., Hoek, J. B., & Vadigepalli, R. (2016) · BMC Genomics · doi:10.1186/s12864-016-2492-x · Cited by 17 · see citing works
Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease
Rastovic, U., Bozzano, S. F., Riva, A., Nieves, A. S., Harris, N., Miquel, R., Lackner, C., Zen, Y., Zamalloa, A., Menon, K. V., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010150 · Cited by 16 · see citing works
Therapeutic effects of cytokine modulator Y‐40138 in the rat alcoholic liver disease model
Kawaratani, H., Tsujimoto, T., Kitazawa, T., Yoshiji, H., Uemura, M., & Fukui, H. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06658.x · Cited by 16 · see citing works
Mercer, K. E., Pulliam, C. F., Hennings, L. J., Lai, K., Cleves, M. A., Jones, E., Drake, R. R., & Ronis, M. J. J. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0417 · Cited by 14 · see citing works
The Involvement of Acetaldehyde in Ethanol-Induced Cell Cycle Impairment
Scheer, M., Schneider, K. J. M., Finnigan, R., Maloney, E., Wells, M., & Clemens, D. L. (2016) · Biomolecules · doi:10.3390/biom6020017 · Cited by 12 · see citing works
Impact of acute schistosomiasis mansoni and long-term ethanol intake on mouse liver pathology
Brandão-Bezerra, L., da Rosa, A. A., de Oliveira, R. M. F., Neves, R. H., Corrêa, C. L., & Machado-Silva, J. R. (2022) · Experimental Parasitology · doi:10.1016/j.exppara.2022.108388 · Cited by 11 · see citing works
Role of Complement in Ethanol-Induced Liver Injury
Pritchard, M. T., McMullen, M. R., Medof, M. E., Stavitsky, A. B., & Nagy, L. E. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-78952-1_13 · Cited by 10 · see citing works
Dasarathy, S., & McCullough, A. J. (2011) · doi:10.1002/9781119950509.ch26 · Cited by 10 · see citing works
Hisada, M., Ota, Y., Zhang, X., Cameron, A. M., Gao, B., Montgomery, R. A., Williams, G. M., & Sun, Z. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04265.x · Cited by 9 · see citing works
Oxidative Stress in Alcoholic Liver Disease
Albano, E. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-15539-5_10 · Cited by 9 · see citing works
Ethanol metabolism activates cell cycle checkpoint kinase, Chk2
Clemens, D. L., Schneider, K. J. M., & Nuss, R. F. (2011) · Alcohol · doi:10.1016/j.alcohol.2011.07.005 · Cited by 8 · see citing works
Effects of short‐ and long‐term use of propolis extracts on liver and kidney in rats
Sılıcı, S., Demiray, S., Okan, A., Ertuğrul, S., Alizada, S., & Doğanyiğit, Z. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4199 · Cited by 7 · see citing works
Hepatotoxicity and Antioxidants: An overview
Fikry, E. M., & Ahmed, A. Y. (2019) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v9i3-s.3089 · Cited by 7 · see citing works
Alcohol: the role in nutrition and health
Suter, P. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818460-8.00025-3 · Cited by 5 · see citing works
Bacterial Infections and Vaccines
Bobat, S., & Cunningham, A. F. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-1489-0_4 · Cited by 2 · see citing works
Timchenko, N. A. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_19 · Cited by 2 · see citing works
Alcohol: Its Role in Nutrition and Health
Suter, P. M. (2012) · doi:10.1002/9781119946045.ch55 · Cited by 2 · see citing works
Dutta, R. K., Du, K., Ren, N., Umbaugh, D. S., Oh, S., Wang, L., Kalsotra, A., Blackshear, P. J., & Diehl, A. (2026) · Gut · doi:10.1136/gutjnl-2025-337019 · Cited by 2 · see citing works
Self-citationAlcohol‐Induced Hepatic Injury
Albano, E. (2009) · doi:10.1002/9783527628100.ch18 · Cited by 1 · see citing works
Hayes, A. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-373593-5.00019-7
Avellini, C., Cesselli, D., Beltrami, A. P., Orsaria, M., Marzinotto, S., Morassi, F., & Uzzau, S. (2013) · InTech eBooks · doi:10.5772/56951
Complement system and alcoholic liver disease
Bykov, I. (2008) · Työväentutkimus Vuosikirja
Estudio de la regeneración hepática bajo una dieta hipercolesterolémica
Lámbarri, N. N. (2011) · doi:10.24275/uami.sx61dm46t
Reuben, A. (2006) · Current Opinion in Internal Medicine · doi:10.1097/01.mog.0000218963.93806.d3
Hayes, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813724-6.00022-0
Pathophysiology of Ethanol and Unexplained Observations
Mueller, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-32483-3_49
Esa, Q. O., & Julia, S. D. (2026) · Research Square · doi:10.21203/rs.3.rs-11533267/v1
- Authors
- Diehl, A. M.
- Affiliations
- Duke University (US)
- Corresponding author
- Diehl, Anna Mae
- ORCID
- Diehl, Anna Mae
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2005-01
- Volume
- 288
- Issue
- 1
- Pages
- G1-G6
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2144267534
- Cited by
- 59
- References
- 27
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R0 AA-10154)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- alcoholic liver disease, ethanol, liver regeneration, alcoholic fatty liver, hepatocyte death, hepatocyte proliferation, liver progenitor cells, progenitor cell differentiation, hepatocyte maturation
- MeSH terms
- Alcohol Drinking, Ethanol, Central Nervous System Depressants, Humans, Liver, Liver Diseases, Alcoholic, Liver Regeneration, Reactive Oxygen Species
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