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Role of polyamines in gastrointestinal mucosal growth
Abstract
The polyamines have been under active investigation for nearly three decades. There is a great deal of evidence that they play an important role in gastrointestinal mucosal growth, but the mechanisms through which this role is carried out are still not fully explained. This review examines the role of the polyamines in the regulation of mucosal growth, the control of intracellular polyamine levels, the biosynthesis of the polyamines, and some known mechanisms of their action. Finally, we propose a model of polyamine action that reconciles the effects of various trophic agents and situations in which growth is stimulated along with concomitant changes in polyamine levels. It accounts for both humoral and gradient-oriented features of various adaptive responses of the gastrointestinal mucosa and is intended to provide a framework for the future investigation of the role of the polyamines in this tissue.
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Citations
Cited by
Blachier, F., Mariotti, F., Huneau, J. F., & Tomé, D. (2007) · Amino Acids · doi:10.1007/s00726-006-0477-9 · Cited by 452
Glutamine, arginine, and leucine signaling in the intestine
Marc Rhoads, J., & Wu, G. (2009) · Amino Acids · doi:10.1007/s00726-008-0225-4 · Cited by 362
Biological significance of dietary polyamines
Larqué, E., Sabater-Molina, M., & Zamora, S. (2007) · Nutrition · doi:10.1016/j.nut.2006.09.006 · Cited by 305
The c‐myc Promoter: Still MysterY and Challenge
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211
Chen, J., Rao, J. N., Zou, T., Liu, L., Marasa, B. S., Xiao, L., Zeng, X., Turner, D. J., & Wang, J.-Y. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00201.2007 · Cited by 107
Metadata
- Authors
- McCormack, S. A., & Johnson, L. R.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 1991-06-01
- Volume
- 260
- Issue
- 6
- Pages
- G795-G806
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2271366439
- Cited by
- 179
- References
- 0
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- McCormack, S. A., & Johnson, L. R. (1991). Role of polyamines in gastrointestinal mucosal growth. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.1991.260.6.g795
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
