The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis
Abstract
Opening of a high-conductance pore conducting solutes of molecular mass <1,500 Da causes onset of the mitochondrial permeability transition (MPT). Cyclosporin A blocks this pore and prevents acute necrotic cell death in several models. Confocal microscopy directly visualizes onset of the MPT during acute cytotoxicity from the movement of the green-fluorescing fluorophore, calcein, into the mitochondria from the cytosol. The MPT also plays a causative role in tumor necrosis factor-α-induced apoptosis in hepatocytes. Progression to apoptosis or necrosis after the MPT may depend on the presence or absence, respectively, of ATP. Often, features of both apoptotic and necrotic cell death develop after death signals and toxic stresses. The term “necrapoptosis” is introduced to emphasize the shared pathways leading to both forms of cell death.
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Cited by
Cell death: a review of the major forms of apoptosis, necrosis and autophagy
D’Arcy, M. S. (2019) · Cell Biology International · doi:10.1002/cbin.11137 · Cited by 2,307
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Self-citationVariants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3)
Lemasters, J. J. (2014) · Redox Biology · doi:10.1016/j.redox.2014.06.004 · Cited by 317
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Metadata
- Authors
- Lemasters, J. J.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 1999-01-01
- Volume
- 276
- Issue
- 1
- Pages
- G1-G6
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W1878685619
- Cited by
- 383
- References
- 39
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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