Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

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CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

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Hapten-Induced Model of Chronic Inflammation and Ulceration in the Rat Colon

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The serotonin signaling system: from basic understanding to drug development for functional GI disorders

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Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome 1 ☆

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Altered Brain Serotonin Homeostasis and Locomotor Insensitivity to 3,4-Methylenedioxymethamphetamine (“Ecstasy”) in Serotonin Transporter-Deficient Mic

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Maintenance of Serotonin in the Intestinal Mucosa and Ganglia of Mice that Lack the High-Affinity Serotonin Transporter: Abnormal Intestinal Motility and the Expression of Cation Transporters

Chen, J. C., Li, Z., Pan, H., Murphy, D. L., Tamir, H., Koepsell, H., & Gershon, M. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06348.2001 · Cited by 397

Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor

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Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis

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Selective inhibition of mucosal serotonin as treatment for IBD?

Levin, A. D., & BRINK, G. R. V. D. (2013) · Gut · doi:10.1136/gutjnl-2013-305283 · Cited by 28

NOD1 downregulates intestinal serotonin transporter and interacts with other pattern recognition receptors

Layunta, E., Latorre, E., Forcén, R., Grasa, L., Plaza, M. A., Arias, M., Alcalde, A. I., & Mesonero, J. E. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26229 · Cited by 27

Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation

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Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota

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Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice

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The 5-hydroxytryptamine 4 Receptor Agonist-induced Actions and Enteric Neurogenesis in the Gut

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Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation

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Regulation of the gut barrier by carbohydrates from diet – Underlying mechanisms and possible clinical implications

Bischoff, S. C., Kaden-Volynets, V., Rosa, L. F., Guseva, D., & Seethaler, B. (2021) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2021.151499 · Cited by 23

Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders

Kondo, T., Okada, Y., Saika, S., Yamaguchi, N., Hatakeyama, S., & Maruyama, K. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151418 · Cited by 24

Toll-like Receptor 3 Activation Affects Serotonin Transporter Activity and Expression in Human Enterocyte-like Caco-2 Cells

Mendoza, C., Matheus, N., Latorre, E., Castro, M., Mesonero, J. E., & Alcalde, A. I. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000339057 · Cited by 22

Gastrointestinal pathophysiology in long COVID: Exploring roles of microbiota dysbiosis and serotonin dysregulation in post-infectious bowel symptoms

Yu, L. C. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123153 · Cited by 29

Influence of acute tryptophan depletion on gastric sensorimotor function in humans

Geeraerts, B., Oudenhove, L. V., Boesmans, W., Vos, R. D., Berghe, P. V., & Tack, J. F. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00020.2010 · Cited by 22

Serotonin dynamics in and around the central nervous system: Is autism solvable without fundamental insights?

Janušonis, S. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.05.009 · Cited by 25

Role of Serotonin in MODS

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Needleless transcutaneous electroacupuncture improves rectal distension-induced impairment in intestinal motility and slow waves via vagal mechanisms in dogs.

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Potentiated serotonin signaling in serotonin re‐uptake transporter knockout mice increases enterocyte mass and small intestinal absorptive function

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Limosilactobacillus reuteri ATCC 6475 metabolites upregulate the serotonin transporter in the intestinal epithelium

Engevik, M., Ruan, W., Visuthranukul, C., Shi, Z., Engevik, K. A., Engevik, A. C., Fultz, R., Schady, D. A., Spinler, J. K., & Versalovic, J. (2021) · Beneficial Microbes · doi:10.3920/bm2020.0216 · Cited by 20

The potential influence of microplastics on the microbiome and disease susceptibility in sea turtles

Iurk, V. B., Ingles, M., Correa, G. S., Silva, C. R., Staichak, G., Pileggi, S. A. V., Christo, S. W., Domit, C., & Pileggi, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174298 · Cited by 21

Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice

Weber, S., Volynets, V., Kanuri, G., Bergheim, I., & Bischoff, S. C. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.191 · Cited by 20

5-HT4-mediated neuroprotection: a new therapeutic modality on the way?

Gershon, M. D. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00120.2016 · Cited by 20

Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats

Kawahara, I., Kuniyasu, H., Matsuyoshi, H., Goto, K., Obata, K., Misawa, H., Fujii, H., & Takaki, M. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00284.2011 · Cited by 19

The Nutrient and Metabolite Profile of 3 Complementary Legume Foods with Potential to Improve Gut Health in Rural Malawian Children

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Enteric Nervous System Structure and Neurochemistry Related to Function and Neuropathology

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The contribution of neuronal–glial–endothelial–epithelial interactions to colon carcinogenesis

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Anticolitis activity of chinese herbal formula Yupingfeng powder via regulating colonic enterochromaffin cells and serotonin

Qin, H., Zang, K.-H., Rao, Z., & Zhang, G. (2015) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.169584 · Cited by 17

NOD2 Modulates Serotonin Transporter and Interacts with TLR2 and TLR4 in Intestinal Epithelial Cells

Layunta, E., Latorre, E., Forcén, R., Grasa, L., Castro, M., Arias, M. A., Alcalde, A. I., & Mesonero, J. E. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000490218 · Cited by 17

Gatekeepers of intestinal inflammation

Arnett, H. A., & Viney, J. L. (2009) · Inflammation Research · doi:10.1007/s00011-009-0091-x · Cited by 15

Role of serotonergic system in the pathogenesis of fibrosis in canine idiopathic inflammatory myopathies.

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Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation

Poplaski, V. B., Bomidi, C., Kambal, A., Nguyen‐Phuc, H., Rienzi, S. C. D., Danhof, H. A., Zeng, X.-L., Feagins, L. A., Deng, N., Vilar, E., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci166884 · Cited by 15

Effects of dietary tryptophan levels on growth performance, serotonin metabolism, brain 5-HT and cannibalism activities in tiger puffer, Takifugu rubripes fingerlings

Wei, Y., Zhou, Z., Zhang, Z., Zhao, L., Yanlu, L., Ma, Q., Liang, M., & Xu, H. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741313 · Cited by 14

Mast Cells and Serotonin Synthesis Modulate Chagas Disease in the Colon: Clinical and Experimental Evidence

Kannen, V., Sakita, J. Y., Carneiro, Z. A., Bäder, M., Alenina, N. V., Teixeira, R. R., de Oliveira, Ê. C., Brunaldi, M. O., Gasparotto, B., Sartori, D. C., et al. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5015-6 · Cited by 14

Association of Serotonin Transporter Promoter Polymorphism (5HTTLPR) with Microscopic Colitis and Ulcerative Colitis: Time to Be AsSERTive?

Goldner, D. L., & Margolis, K. G. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3598-8 · Cited by 14

Enhanced serotonin signaling increases intestinal neuroplasticity

Greig, C. J., Gandotra, N., Tackett, J. J., Bamdad, M. C., & Cowles, R. A. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.07.021 · Cited by 14

The Anti‐Inflammatory Effect of Guchangzhixie‐Pill by Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in an Ulcerative Colitis Rat Model

Yang, Y., Zhu, X., Qin, Y., Chen, G., Zhou, J., Li, L., Guan, J., Ma, L., Xue, Y., & Li, C. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/8547257 · Cited by 13

Molecular mechanisms and therapeutic potential of tryptophan metabolism in gut-brain signaling transduction: a narrative review

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Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding

Hoch, J., Burkhard, N., Zhang, S., Rieder, M., Marchini, T., Geest, V., Krauel, K., Zahn, T., Schommer, N., Hamad, M. A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1184010 · Cited by 12

Pharmaco-psychiatry and gut microbiome: a systematic review of effects of psychotropic drugs for bipolar disorder

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Role of serotonin in fatty acid-induced non-alcoholic fatty liver disease in mice

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Neuroimmunogastroenterology: At the Interface of Neuroimmunology and Gastroenterology

Sanchez, J. M. S., McNally, J. S., Cortez, M. M., Hemp, J., Pace, L., & Clardy, S. L. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00787 · Cited by 13

Alteration of serotonin transporter messenger RNA level in the peripheral blood mononuclear cells from simian/human immunodeficiency virus infected Chinese rhesus macaques (Macaca mulatta)

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Effect of sumatriptan on acetic acid-induced experimental colitis in rats: a possible role for the 5‐HT1B/1D receptors

Hosseini, R., Fakhraei, N., Malekisarvar, H., Mansourpour, D., Nili, F., Farahani, M. S., & Dehpour, A. R. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02215-5 · Cited by 11

Potentiation of serotonin signaling protects against intestinal ischemia and reperfusion injury in mice

Tackett, J. J., Gandotra, N., Bamdad, M. C., Muise, E. D., & Cowles, R. A. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13498 · Cited by 11

The Microbiome and the Epigenetics of Diabetes Mellitus

Dávila, L. A., Bermúdez, V., Díaz, W., Villasmil, N. R., Cisternas, S., Contreras, M. C. E., Kristian Buhring, B., Durán‐Agüero, S., Vergara, P. C., Bonacich, R. B., et al. (2018) · InTech eBooks · doi:10.5772/intechopen.76201 · Cited by 10

Neuroimmune Crossroads: The Interplay of the Enteric Nervous System and Intestinal Macrophages in Gut Homeostasis and Disease

Lou, M., Heuckeroth, R. O., & Tjaden, N. E. B. (2024) · Biomolecules · doi:10.3390/biom14091103 · Cited by 11

Luteolin suppresses 5-hydroxytryptamine elevation in stimulated RBL-2H3 cells and experimental colitis mice

Suga, N., Murakami, A., Arimitsu, H., Nakamura, T., Nakamura, Y., & Kato, Y. (2021) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.20-192 · Cited by 9

Impact of Serotonin Transporter Absence on Brain Insulin Receptor Expression, Plasma Metabolome Changes, and ADHD-like Behavior in Mice fed a Western Diet

Anthony, D. C., Probert, F., Вячеславовна, Г. А., Hebert, J. C., Radford‐Smith, D. E., Nefedova, Z., Umriukhin, A., Nedorubov, A. A., Cespuglio, R., Shulgin, B., et al. (2024) · Biomolecules · doi:10.3390/biom14080884 · Cited by 11

Magnetically-Propelled Fecal Surrogates for Modeling the Impact of Solid-Induced Shear Forces on Primary Colonic Epithelial Cells

Hinman, S. S., Huling, J. C., Wang, Y., Wang, H., Bretherton, R. C., DeForest, C. A., & Allbritton, N. L. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121059 · Cited by 8

Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation

Perez, F., Kotecha, N., Lavoie, B. A., Mawe, G. M., & Patel, B. A. (2022) · ChemBioChem · doi:10.1002/cbic.202200334 · Cited by 8

Serotonin reuptake transporter deficiency promotes liver steatosis and impairs intestinal barrier function in obese mice fed a Western‐style diet

Rosa, L. F., Haasis, E., Knauss, A., Guseva, D., & Bischoff, S. C. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14611 · Cited by 8

Identification of 5-hydroxytryptamine-producing cells by detection of fluorescence in paraffin-embedded tissue sections

Kaneko, Y., Onda, N., Watanabe, Y., & Shibutani, M. (2016) · European Journal of Histochemistry · doi:10.4081/ejh.2016.2684 · Cited by 7

Hepatocyte nuclear factor-4α regulates expression of the serotonin transporter in intestinal epithelial cells

Holton, N. W., Singhal, M., Kumar, A., Ticho, A. L., Manzella, C. R., Malhotra, P., Jarava, D., Saksena, S., Dudeja, P. K., Alrefai, W. A., et al. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00477.2019 · Cited by 7

Parenteral lipid emulsions induce unique ileal fatty acid and metabolomic profiles but do not increase the risk of necrotizing enterocolitis in preterm pigs

Yakah, W., Singh, P., Brown, J., Stoll, B., Burrin, D. G., Premkumar, M. H., Otu, H. H., Gu, X., Dillon, S. T., Libermann, T. A., et al. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00311.2020 · Cited by 7

The Shaggy Dog Story of Enteric Signaling: Serotonin, a Molecular Megillah

Gershon, M. D. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-05843-1_28 · Cited by 6

Elevated risk of adverse effects from foodborne contaminants and drugs in inflammatory bowel disease: a review

Walraven, T., Busch, M., Wang, J., Donkers, J. M., Duijvestein, M., van de Steeg, E., Kramer, N. I., & Bouwmeester, H. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03844-w · Cited by 6

Digging deep for nutrients and metabolites derived from high dietary protein intake and their potential functions in metabolic health

Gilsenan, S., Leong, D., Cotter, P. D., Brennan, L., & Nilaweera, K. N. (2024) · Nutrition Research Reviews · doi:10.1017/s0954422424000374 · Cited by 5

Acute paraquat exposure impairs colonic motility by selectively attenuating nitrergic signalling in the mouse

Diss, L. B., Dyball, S., Ghela, T., Golding, J. A., Morris, R., Robinson, S., Tucker, R., Walter, T., Young, P., Allen, M. C., et al. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.01.005 · Cited by 8

Effects of Lactobacillus rhamnosus GG on the serotonergic pathway in a gliadin-induced enteropathy animal model

Orlando, A., Clemente, C., D’Attoma, B., & Russo, F. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104077 · Cited by 6

Children with Autism Spectrum Disorder and Chronic Gastrointestinal Symptoms Have Alterations in Intestinal Neurotransmitter Pathways

Tingler, A. M., Figuereo, Y. F., Engevik, K. A., Weis, V. G., Krigsman, A., Engevik, M. A., & Walker, S. J. (2026) · Digestive Diseases and Sciences · doi:10.1007/s10620-026-09667-2 · Cited by 6

Analgesic activity of cynaropicrinon on post‑inflammatory irritable bowel syndrome visceral hypersensitivity in a rat model

Shi, H., Zhu, X., Cui, Y., Qin, Y., Yang, L., & Deng, X. F. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5037 · Cited by 5

Telotristat Etiprate alleviates rheumatoid arthritis by targeting LGALS3 and affecting MAPK signaling

Zhang, L., Lin, Y., Xu, X., Liu, H., Wang, X., & Pan, J. (2023) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2022.01121 · Cited by 5

Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation

Lemmetyinen, T. T., Viitala, E. W., Wartiovaara, L., Päivinen, P., Virtanen, H. T., Pentinmikko, N., Katajisto, P., Mäkelä, T. P., Wang, T. C., Andressoo, J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111246 · Cited by 4

Desloratadine via its anti-inflammatory and antioxidative properties ameliorates TNBS-induced experimental colitis in rats

Bhat, M. A., Roy, S., Dhaneshwar, S. S., Kumar, S., & Saxena, S. K. (2024) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2024.2360043 · Cited by 4

Microbial Neuro-Immune Interactions and the Pathophysiology of IBD

Aguilera, M., & Melgar, S. (2016) · InTech eBooks · doi:10.5772/64832 · Cited by 4

Beyond the Brain: Perinatal Exposure of Rats to Serotonin Enhancers Induces Long-Term Changes in the Jejunum and Liver

Gračan, R., Blažević, S. A., Brižić, M., & Hranilović, D. (2024) · Biomedicines · doi:10.3390/biomedicines12020357 · Cited by 3

UniPR1331: Small Eph/Ephrin Antagonist Beneficial in Intestinal Inflammation by Interfering with Type-B Signaling

Giorgio, C., Allodi, M., Palese, S., Grandi, A., Tognolini, M., Castelli, R., Lodola, A., Flammini, L., Cantoni, A. M., Barocelli, E., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14060502 · Cited by 3

Cellular Regulation of Peripheral Serotonin

Martin, A. M., Young, R. L., Leong, L. E. X., Rogers, G. B., Spencer, N. J., Jessup, C. F., & Keating, D. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-800050-2.00007-3 · Cited by 3

Serotonin Transporter Deficiency Induces Metabolic Alterations in the Ileal Mucosa

Calzadilla, N., Jayawardena, D., Qazi, A., Sharma, A., Mongan, K., Comiskey, S., Eathara, A., Saksena, S., Dudeja, P. K., Alrefai, W. A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084459 · Cited by 3

Short Ileal Microvillus Length Phenotype Associates with Progression from Inflammatory to Complicated Disease Behavior in Pediatric Crohn’s Disease

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The past 10 years of gastroenterology and hepatology—reflections and predictions

Friedman, S. L., Quigley, E. M. M., Sharkey, K. A., Sung, J. J. �., & Whitcomb, D. C. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.167 · Cited by 2

Protective actions of a luminally acting 5‐HT4 receptor agonist in mouse models of colitis

Hurd, M., Haag, M. M., Kwasnik, M. J., Wykosky, J., Lavoie, B. A., & Mawe, G. M. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14673 · Cited by 2

Serotonin as a Regulator of Innate and Adaptive Immunity: Mechanisms and Clinical Relevance in Inflammatory Disease

Inozemtsev, V. A., Shashkovskaya, V. S., & Sergunova, V. A. (2026) · Cells · doi:10.3390/cells15151353 · Cited by 1

"Recognizing Hunger" - A Training to Abate Insulin Resistance, Associated Subclinical Inflammation and Cardiovascular Risks

Ciampolini, M. (2012) · InTech eBooks · doi:10.5772/32354

Neurogenetics, Genome-Wide Association and Candidate Gene Studies

Haller, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-46331-1_3 · Cited by 1

Cecal Metabolome Profiles of Turkey Poults in Response to Salmonella Heidelberg Challenge with or Without Turkey-Derived Lactobacillus Probiotic and Trans-Cinnamaldehyde

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Additional file 1 of ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome

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Additional file 4 of ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome

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Additional file 1 of Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells

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Additional file 5 of ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome

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Additional file 6 of ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome

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Additional file 3 of ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome

Zhang, L., Ye, C., Li, P., Li, C., Shu, W., Zhao, Y., & Wang, X. (2022) · Figshare · doi:10.6084/m9.figshare.20962378

Additional file 2 of ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome

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