The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Alternans and spiral breakup in a human ventricular tissue model
Abstract
Ventricular fibrillation (VF) is one of the main causes of death in the Western world. According to one hypothesis, the chaotic excitation dynamics during VF are the result of dynamical instabilities in action potential duration (APD) the occurrence of which requires that the slope of the APD restitution curve exceeds 1. Other factors such as electrotonic coupling and cardiac memory also determine whether these instabilities can develop. In this paper we study the conditions for alternans and spiral breakup in human cardiac tissue. Therefore, we develop a new version of our human ventricular cell model, which is based on recent experimental measurements of human APD restitution and includes a more extensive description of intracellular calcium dynamics. We apply this model to study the conditions for electrical instability in single cells, for reentrant waves in a ring of cells, and for reentry in two-dimensional sheets of ventricular tissue. We show that an important determinant for the onset of instability is the recovery dynamics of the fast sodium current. Slower sodium current recovery leads to longer periods of spiral wave rotation and more gradual conduction velocity restitution, both of which suppress restitution-mediated instability. As a result, maximum restitution slopes considerably exceeding 1 (up to 1.5) may be necessary for electrical instability to occur. Although slopes necessary for the onset of instabilities found in our study exceed 1, they are within the range of experimentally measured slopes. Therefore, we conclude that steep APD restitution-mediated instability is a potential mechanism for VF in the human heart.
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Cites
Mathematical Physiology: I: Cellular Physiology
(2009) · Interdisciplinary Applied Mathematics · doi:10.1007/978-0-387-75847-3 · Cited by 2,175
Keener, J., & Sneyd, J. (1998) · Interdisciplinary Applied Mathematics · doi:10.1007/b98841 · Cited by 1,529
Luo, C. H., & Rudy, Y. (1991) · Circulation Research · doi:10.1161/01.res.68.6.1501 · Cited by 1,468
A model for human ventricular tissue
ten Tusscher, K. H. W. J., Noble, D., Noble, P. J., & Panfilov, A. V. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00794.2003 · Cited by 1,416
Self-citationCircus movement in rabbit atrial muscle as a mechanism of trachycardia.
Allessie, M. A., BONKE, F. I. M., & Schopman, F. J. G. (1973) · PubMed · Cited by 686
A Mathematical Treatment of Integrated Ca Dynamics within the Ventricular Myocyte
Shannon, T. R., Wang, F., Puglisi, J., Weber, C., & Bers, D. M. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.047449 · Cited by 541
A graphic method for the study of alternation in cardiac action potentials.
Nolasco, J. B., & Dahlen, R. W. (1968) · Journal of Applied Physiology · doi:10.1152/jappl.1968.25.2.191 · Cited by 483
Electrical alternans and spiral wave breakup in cardiac tissue
Karma, A. (1994) · Chaos: An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/1.166024 · Cited by 479
Evidence for Two Components of Delayed Rectifier K+Current in Human Ventricular Myocytes
Li, G.-R., Feng, J., Yue, L., Carrier, M., & Nattel, S. (1996) · Circulation Research · doi:10.1161/01.res.78.4.689 · Cited by 470
Circus Movement in Rabbit Atrial Muscle as a Mechanism of Tachycardia
ALLESSIE, M. A., BONKE, F. I. M., & SCHOPMAN, F. J. G. (1973) · Circulation Research · doi:10.1161/01.res.33.1.54 · Cited by 465
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O'Hara, T., Virág, L., Varró, A., & Rudy, Y. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002061 · Cited by 1,196
Verification of cardiac tissue electrophysiology simulators using an N -version benchmark
Niederer, S. A., Kerfoot, E., Benson, A. P., Bernabeu, M. O., Bernus, O., Bradley, C., Cherry, E. M., Clayton, R., Fenton, F. H., Garny, A., et al. (2011) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2011.0139 · Cited by 275
Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes
Lieu, D. K., Fu, J.-D., Chiamvimonvat, N., Tung, K. C., McNerney, G. P., Huser, T., Keller, G., Kong, C.-W., & Li, R. A. (2013) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.111.973420 · Cited by 179
Strocchi, M., Augustin, C. M., Gsell, M. A. F., Karabelas, E., Neic, A., Gillette, K., Razeghi, O., Prassl, A. J., Vigmond, E. J., Behar, J. M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235145 · Cited by 112
Strocchi, M., Lee, A. W. C., Neic, A., Bouyssier, J., Gillette, K., Plank, G., Elliott, M. K., Gould, J., Behar, J. M., Sidhu, B., et al. (2020) · Heart Rhythm · doi:10.1016/j.hrthm.2020.06.028 · Cited by 73
Metadata
- Authors
- ten Tusscher, K. H. W. J., & Panfilov, A. V.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2006-09
- Volume
- 291
- Issue
- 3
- Pages
- H1088-H1100
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2163071496
- Cited by
- 1,122
- References
- 43
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- closed
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