The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Circulating microRNAs as diagnostic biomarkers for cardiovascular diseases
Abstract
One of the major challenges in cardiovascular disease is the identification of reliable clinical biomarkers that can be routinely measured in plasma. MicroRNAs (miRNAs) were recently discovered to circulate in the bloodstream in a remarkably stable form. Because of their stability and often tissue- and disease-specific expression and the possibility to measure them with high sensitivity and specificity, miRNAs are emerging as new diagnostic biomarkers. In this review we will provide an overview of the potential of circulating miRNAs as biomarkers for a wide range of cardiovascular diseases such as coronary artery disease, myocardial infarction, hypertension, heart failure, viral myocarditis, and type-2 diabetes mellitus. Furthermore, we will discuss the challenges with regard to further validation in large patient cohorts, and we will discuss how the measurement of multiple miRNAs simultaneously might improve the accuracy of the diagnostic test.
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Cites
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Caporali, A., Meloni, M., Völlenkle, C., Bonci, D., Sala-Newby, G. B., Addis, R., Spinetti, G., Losa, S., Masson, R., Baker, A. H., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.952325 · Cited by 397
Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure
Cheng, J., Ke, Q., Jin, Z., Wang, H., Kocher, O., Morgan, J. P., Zhang, J., & Crumpacker, C. S. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000427 · Cited by 163
Cited by
Mogilyansky, E., & Rigoutsos, I. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.125 · Cited by 889
miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges
Zhou, S.-S., Jin, J.-P., Wang, J.-Q., Zhang, Z.-G., Freedman, J. H., Zheng, Y., & Cai, L. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.30 · Cited by 675
Chow, S. L., Maisel, A. S., Anand, I., Bozkurt, B., de Boer, R. A., Felker, G. M., Fonarow, G. C., Greenberg, B., Januzzi, J. L., Kiernan, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000490 · Cited by 601
Metadata
- Authors
- Tijsen, A. J., Pinto, Y. M., & Creemers, E. E.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2012-11-01
- Volume
- 303
- Issue
- 9
- Pages
- H1085-H1095
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2134294936
- Cited by
- 213
- References
- 3
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tijsen, A. J., Pinto, Y. M., & Creemers, E. E. (2012). Circulating microRNAs as diagnostic biomarkers for cardiovascular diseases. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00191.2012
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