The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges
Open accessAbstract
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although considerable progress has been made in the diagnosis, treatment and prognosis of CVD, there is still a critical need for novel diagnostic biomarkers and new therapeutic interventions to decrease the incidence of this disease. Recently, there is increasing evidence that circulating miRNAs (miRNAs), i.e. endogenous, stable, single-stranded, short, non-coding RNAs, can be used as diagnostic biomarkers for CVD. Furthermore, miRNAs represent potential novel therapeutic targets for several cardiovascular disorders. In this review we provides an overview of the effects of several CVD; including heart failure, acute myocardial infarction, arrhythmias and pulmonary hypertension; on levels of circulating miRNAs. In addition, the use of miRNA as therapeutic targets is also discussed, as well as challenges and recommendations in their use in the diagnosis of CVD.
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Biomarkers for the diagnosis and management of heart failure
Castiglione, V., Aimo, A., Vergaro, G., Saccaro, L., Passino, C., & Emdin, M. (2022) · Heart Failure Reviews · doi:10.1007/s10741-021-10105-w · Cited by 512
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208
Cardiovascular Risk and Resilience Among Black Adults: Rationale and Design of the MECA Study
Islam, S. J., Kim, J. H., Topel, M., Liu, C., Ko, Y., Mujahid, M. S., Sims, M., Mubasher, M., Ejaz, K., Morgan‐Billingslea, J., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015247 · Cited by 23
Kalpachidou, T., Kummer, K. K., Mitrić, M., & Kress, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00283 · Cited by 10
Metadata
- Authors
- Zhou, S.-S., Jin, J.-P., Wang, J.-Q., Zhang, Z.-G., Freedman, J. H., Zheng, Y., & Cai, L.
- Venue
- Acta Pharmacologica Sinica
- Published
- 2018-06-07
- Volume
- 39
- Issue
- 7
- Pages
- 1073-1084
- ISSN
- 0253-9756 (ISSN-L)
- 1671-4083
- 1745-7254
- OpenAlex
- W2807343509
- Cited by
- 675
- References
- 112
- FWCI
- 13.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhou, S.-S., Jin, J.-P., Wang, J.-Q., Zhang, Z.-G., Freedman, J. H., Zheng, Y., & Cai, L. (2018). miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges. Acta Pharmacologica Sinica. https://doi.org/10.1038/aps.2018.30
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