Adropin: A hepatokine modulator of vascular function and cardiac fuel metabolism
Open accessAbstract
Adropin is a nutritionally regulated peptide hormone, secreted primarily by the liver, which modulates metabolic homeostasis in a number of tissues. Growing evidence suggests that adropin is an important regulatory component in a number of cardiovascular pathologies, and may be central to the control of cardiac fuel metabolism and vascular function. In this mini-review, we examine the known facets of adropin biology, discuss open questions in the field, and speculate on the therapeutic potential of targeting adropin-related signaling pathways in cardiovascular diseases.
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Adropin increases fibronectin and elastin expression in vascular smooth muscle cells (VSMCs) by overloading the PI3K-Akt pathway.
“In this scenario, it was also observed that adropin increases fibronectin and elastin expression in vascular smooth muscle cells (VSMCs) by overloading the PI3K-Akt pathway, thus assuming that adropin regulates plaque stability and elasticity vascular [112].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [112]
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- Authors
- Mushala, B. A. S., & Scott, I.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Scott, Iain
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2021-01-01
- Volume
- 320
- Issue
- 1
- Pages
- H238-H244
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC7847067
- OpenAlex
- W3106221998
- Cited by
- 53
- References
- 33
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 8 · 2023: 12 · 2022: 13 · 2021: 6
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Heart, Lung, and Blood Institute (R01HL132917, R01HL147861)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adropin, hepatokines, vascular function, cardiovascular disease, metabolic homeostasis, peptide hormones, therapeutic targeting
- MeSH terms
- Animals, Blood Vessels, Cardiovascular Agents, Cardiovascular Diseases, Energy Metabolism, Humans, Myocardium, Signal Transduction, Intercellular Signaling Peptides and Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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