The genetic contribution to heart rate and heart rate variability in quiescent mice
Open accessAbstract
Recent studies have suggested a genetic component to heart rate (HR) and HR variability (HRV). However, a systematic examination of the genetic contribution to the variation in HR and HRV has not been performed. This study investigated the genetic contribution to HR and HRV using a wide range of inbred and recombinant inbred (RI) mouse strains. Electrocardiogram data were recorded from 30 strains of inbred mice and 29 RI strains. Significant differences in mean HR and total power (TP) HRV were identified between inbred strains and RI strains. Multiple significant differences within the strain sets in mean low-frequency (LF) and high-frequency (HF) power were also found. No statistically significant concordance was found between strain distribution patterns for HR and HRV phenotypes. Genomewide interval mapping identified a significant quantitative trait locus (QTL) for HR [LOD (likelihood of the odds) score = 3.763] on chromosome 6 [peak at 53.69 megabases (Mb); designated HR 1 ( Hr1)]. Suggestive QTLs for TP were found on chromosomes 2, 4, 5, 6, and 14. A suggestive QTL for LF was found on chromosome 16; for HF, we found one significant QTL on chromosome 5 (LOD score = 3.107) [peak at 53.56 Mb; designated HRV-high-frequency 1 ( Hrvhf1)] and three suggestive QTLs on chromosomes 2, 11 and 15. In conclusion, the results demonstrate a strong genetic component in the regulation of resting HR and HRV evidenced by the significant differences between strains. A lack of correlation between HR and HRV phenotypes in some inbred strains suggests that different sets of genes control the phenotypes. Furthermore, QTLs were found that will provide important insight to the genetic regulation of HR and HRV at rest.
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Various cardiac functions, parameters, properties, and responses to stress vary depending on mouse strains.
“various cardiac functions, parameters, properties, and response to stress vary depending on the mouse strains (Barnabei, Palpant, & Metzger, 2010; Hoit, et al., 2002; Howden, et al., 2008; A. P. Shah, et al., 2010; Stull, et al., 2006; van den Borne, et al., 2009).”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Howden, et al., 2008
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Small and large animal models in cardiac contraction research: advantages and disadvantages
Milani-Nejad, N., & Janssen, P. M. L. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.007 · Cited by 484 · see citing works
- Authors
- Howden, R., Liu, E., Miller-DeGraff, L., Keener, H. L., Walker, C., Clark, J. A., Myers, P. H., Rouse, D. C., Wiltshire, T., & Kleeberger, S. R.
- Affiliations
- National Institutes of Health (US)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2008-07
- Volume
- 295
- Issue
- 1
- Pages
- H59-H68
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC2494744
- OpenAlex
- W2171291567
- Cited by
- 25
- References
- 46
- Citations by year
- 2025: 1 · 2023: 1 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 6 · 2012: 1
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- heart rate, heart rate variability, genetic contribution, quantitative trait loci, recombinant inbred mouse strains, inbred mouse strains, interval mapping
- MeSH terms
- Animals, Chromosome Mapping, Genotype, Heart Rate, Lod Score, Male, Mice, Inbred Strains, Phenotype, Pulmonary Ventilation, Species Specificity, Telemetry, Tidal Volume, Respiratory Mechanics, Electrocardiography, Ambulatory, Quantitative Trait Loci, Mice
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